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At least 667 records · Page 37Linked to original sources
PubMed1977

Worm burden of onchocerca volvulus in a hyperendemic village of the rain-forest in West Africa.

During a study on the effects of nodulectomy on onchocerciasis in a village in the Liberian rain-forest 400 Onchocerca-nodules were excised from 34 inhabitants. The analysis of the nodules revealed a worm burden of 718 complete live male and 1062 complete live female worms as well as 9 male and 117 female worms which were mostly calcified and degenerating. 73% of the live females contained developing embryos or released microfilariae, the other females either contained eggs or showed empty uteri. Some observations were made on degenerating worms. The male:female sex ratio was 1:1.5 and possible reasons for this are discussed.

Adolescent↗
PubMed1982

Attempts to establish Onchocerca volvulus infection in primates and small laboratory animals.

Attempts were made to transmit O. volvulus infection to small laboratory animals and several species of primates to identify a practical laboratory host for human onchocerciasis. Infective larvae of O. volvulus of Guatemalan origin were inoculated into the following animals: rhesus monkeys, bonnet monkeys, golden spider monkeys, black spider monkeys, galagos, opossums, jirds, newborn and adult Swiss mice, kinkajou, cebus monkey, normal and splenectomized multimammate rats, and a calf. The animals were examined for signs of developing infection for up to two years after inoculation. None of the animals tested developed a patent infection, and neither larvae nor O. volvulus adults were found during the necropsy of all the animals which died or were killed during or at the end of the examination period. It is concluded that none of the animals tested is susceptible to infection with O. volvulus.

Animals↗
PubMed1968

The effects of drugs on Onchocerca volvulus. 2. The antimonial preparations TWSb and MSbE.

Antimonial preparations (Pentostam, Neostibosan, stibophen, and tartar emetic) have occasionally been used in the treatment of onchocerciasis without very promising results. The advent of the preparations TWSb (stibocaptate) and MSbE (Friedheim) of allegedly reduced toxicity made it desirable to test them against Onchocerca volvulus.The action of both preparations on the parasites was found to vary from one patient to another, ranging from complete elimination of all parasites in a few cases to no detectable action in others. A microfilaricidal action was detectable in many patients, particularly after treatment with TWSb, which was used at higher doses than MSbE. A lethal or sterilizing action on some or all adult female worms was observed in some patients. However, toxic reactions to the drugs were common and distressing, and often it was necessary to stop treatment on this account. Anorexia, nausea, vomiting and prostration were the most common manifestations, and there was one fatality from coincident yellow fever, which may well have been aggravated by antimony treatment.The uncertain action of these preparations on O. volvulus and the toxic manifestations that accompany their use render them unsuitable for the treatment of onchocerciasis, and it is probable that the effects of antimony on O. volvulus are produced only at or above the normal level of human tolerance.

Animals↗
PubMed1985

A field method for the procurement of infective larvae of Onchocerca volvulus.

Natural vectors of onchocerciasis (S. yahense) were collected. Ninety-eight were intrathoracically inoculated with 30 freshly obtained skin-dwelling microfilariae. Of the 82 flies dissected, 56 were infected and 28 harbored infective larvae. A total of 193 infective O. volvulus larvae were obtained. The mean infective worm burden was 6.9.

Humans↗