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Results for “SLEEP DEPRIVATION”

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PubMed1993

Effects of rapid eye movement sleep deprivation on the properties of striatal dopaminergic system.

Using the water tank procedure, we have examined the effects of rapid eye movement (REM) sleep deprivation and associated stress on the properties of striatal dopaminergic system. While stress decreased the number of D1 and D2 dopamine receptors, a combination of REM sleep deprivation attenuated the decrease. The ratio of D1 to D2 densities, however, increased on both the stress and REM sleep deprivation groups. In contrast, the number of dopamine uptake sites remained unchanged. The enhanced behavioral responses to dopaminergic stimulants after REM sleep deprivation are discussed.

Animals↗

PubMed2004

Identification and differential vulnerability of a neural network in sleep deprivation.

The study aimed to identify task-related brain activation networks whose change in expression exhibits subject differences as a function of differential susceptibility to sleep deprivation. Brain activity during a non-verbal recognition memory task was investigated in an event-related functional MRI paradigm both prior to and after 48 h of sleep deprivation. Nineteen healthy subjects participated. Regional covariance analysis was applied to data. An activation network pattern was identified whose expression decreased from pre- to post-sleep deprivation in 15 out 19 subjects (P < 0.05). Differential decrease in expression correlated with worsening performance in recognition accuracy (P < 0.05). Sites of de-activation were found in the posterior cerebellum, right fusiform gyrus and precuneus, and left lingual and inferior temporal gyri; increased activation was found in the bilateral insula, claustrum and right putamen. A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation.

Adaptation, Physiological↗

PubMed1991

Sleep deprivation in the rat: XII. Effect on ambient temperature choice.

Previous studies of total sleep deprivation in the rat by the disk-over-water method had shown an initial rise in body temperature (Tb), a later decline to below baseline levels, and a progressive rise in energy expenditure (EE). To evaluate the role of changes in temperature setpoint in these results, the ambient temperature choices (Tc) of six totally sleep-deprived (TSD) rats and their yoked control (TSC) rats were determined by the position in a thermally graded alley at which they chose to fall asleep. (Rats were removed from the alley and returned to the deprivation apparatus 1 min after sleep onset). Sleep deprivation was continued until TSD rats were near death. Tb and EE results were like those of the earlier studies. Tc rose progressively from 26.8 degrees C during baseline to 49.9 degrees C near the end of the deprivation period in TSD rats, whereas TSC rats showed only modest, nonsignificant increases. The attempt by TSD rats to get warmer, in spite of an elevated Tb, indicates a raised setpoint for behavioral thermoregulation and suggests that the increase in EE was also, at least in part, an attempt to reach an elevated setpoint. The progressively raised Tc also indicates that the late decline in Tb was a decline below setpoint rather than a response to a lower setpoint. Because EE increased, Tb decline must have resulted from excessive heat loss. Thus, TSD in the rat produced two thermoregulatory deficits-increased setpoint and excessive heat loss.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1981

Sleep deprivation psychoprophylaxis in recurrent affective disorders.

Administration of prophylactic 36 h total sleep deprivation to 9 manic-depressive patients (5 bipolar and 4 unipolar depressives) reduced the frequency of relapses and increased the duration of normothymia in 5 patients, left the course of illness unchanged in 3 patients whilst in 1 patient the effect could not be evaluated. Sleep deprivation appeared to be more effective in women, 'rapid cyclers', patients with a positive family history of mental illness and patients with recurrent depression. These observations confirm previous impressions and suggest a possible prophylactic effect of sleep deprivation.

Adult↗

PubMed2001

The effects of 1 week of REM sleep deprivation on parvalbumin and calbindin immunoreactive neurons in central visual pathways of kittens.

Many maturational processes in the brain are at high levels prenatally as well as neonatally before eye-opening, when extrinsic sensory stimulation is limited. During these periods of rapid brain development, a large percentage of time is spent in rapid eye movement (REM) sleep, a state characterized by high levels of endogenously produced brain activity. The abundance of REM sleep in early life and its ensuing decline to lower levels in adulthood strongly suggest that REM sleep constitutes an integral part of the activity-dependent processes that enable normal physiological and structural brain development. We examined the effect of REM sleep deprivation during the critical period for visual development on the development of two calcium-binding proteins that are associated with developmental synaptic plasticity and are found in the lateral geniculate nucleus (LGN) and visual cortex. In this study, REM sleep deprivation was carried out utilizing a computer-controlled, cage-shaking apparatus that successfully suppressed REM sleep. Body weight data suggested that this method of REM sleep deprivation produced less stress than the classical multiple-platform-over-water method. In REM sleep-deprived animals with normal binocular vision, the number of parvalbumin-immunoreactive (PV) neurons in LGN was found to be lower compared with control animals but was not affected in visual cortex. The pattern of calbindin-immunoreactivity (CaB) was unchanged at either site after REM sleep deprivation. Parvalbumin-immunoreactivity develops later than calbindin-immunoreactivity in the LGN, and the REM sleep deprivation that we applied from postnatal day 42-49 delayed this essential step in the development of the kitten's visual system. These data suggest that in early postnatal brain development, REM sleep facilitates the usual time course of the expression of PV-immunoreactivity in LGN neurons.

Animals↗

PubMedDate not supplied

Health effects of sleep deprivation.

This report provides information supporting the conclusion that sleep deprivation produces only very small biomedical effects. It nonetheless concludes that chronic partial sleep deprivation may contribute to gastrointestinal disorders, cardiovascular disease, and other medical conditions that occur more often in shiftworkers than in permanent dayworkers.

Health Status↗

PubMed2002

Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement.

Hypocretins (orexins) are recently discovered hypothalamic neuropeptides that have been implicated in the etiology of narcolepsy. The normal behavioral functions of these peptides are unclear, although a role in feeding has been suggested. We measured hypocretin-1 (Hcrt-1) in the cerebrospinal fluid of dogs during a variety of behaviors. We found that 48 h without food (24 h beyond normal 24-h fasting period) produced no significant change in Hcrt-1 levels nor did feeding after the deprivation. In contrast, 24 h of sleep deprivation produced on average a 70% increase in Hcrt-1 level compared with baseline levels. The amount of increase was correlated with the level of motor activity during the sleep-deprivation procedure. A 2-h period of exercise in the same dogs produced a 57% increase in Hcrt-1 levels relative to quiet waking levels, with the magnitude of the increase being highly correlated with the level of motor activity. The strong correlation between motor activity and Hcrt-1 release may explain some of the previously reported behavioral, physiological, and pathological phenomena ascribed to the Hcrt system.

Aging↗

PubMed2004

Thermal and metabolic responses of sleep deprivation of humans during acute cold exposure.

PURPOSE: This investigation evaluated the effects of 33 h of sleep deprivation on the thermoregulation in 12 male and female subjects (26.6 +/- 6.4 yrs) during 180 min of cold exposure in 12 degrees C air. METHODS: Subjects underwent two cold air trials (CAT): one following a normal night of sleep (i.e., 6-8 h) (CON); and one following 33 h of sleep deprivation (SDEP). Rectal temperature (Tre), mean skin temperature (Tsk), heat production (HP), and tissue insulation (Iti), were measured at 5, 15, 30, and every 30 min thereafter. RESULTS: ANOVA revealed no significant differences (p > 0.05) between CON and SDEP for Tre, Tsk, HP, and Iti. A main effect for time was demonstrated for Tre, Iti, HP, and Tsk. A trial x time interaction for Tre and Tsk (p = 0.021) was demonstrated. DISCUSSION: Significant interactions were demonstrated for Tre and Tsk, but post hoc analysis determined no differences between SDEP and CON. This may have been due to the length of the sleep deprivation, cold stressor, or a combination of the two. There were also no overall differences in HP or Iti between SDEP and CON. Further research in this area is needed to evaluate the effects of sleep deprivation during acute cold exposure.

Adolescent↗

PubMed1999

[Sleep deprivation and aging].

We investigated the impact of old age on the antidepressant effect of sleep deprivation. 32 depressive inpatients were assessed before and after sleep deprivation by the Hamilton Depression Rating Scale. The patients were divided into two groups according to their age. The result showed no negative impact of old age on the anti-depressant effect of sleep deprivation.

Adolescent↗

PubMed2000

Homeostasis of REM sleep after total and selective sleep deprivation in the rat.

During specific rapid eye movement (REM) sleep deprivation its homeostatic regulation is expressed by progressively more frequent attempts to enter REM and by a compensatory rebound after the deprivation ends. The buildup of pressure to enter REM may be hypothesized to depend just on the time elapsed without REM or to be differentially related to non-REM (NREM) and wakefulness. This problem bears direct implications on the issue of the function of REM and its relation to NREM. We compared three protocols that combined REM-specific and total sleep deprivation so that animals underwent similar 3-h REM deprivations but different concomitant NREM deprivations for the first 2 (2T1R), 1 (1T2R), or 0 (3R) hours. Deprivation periods started at hour 6 after lights on. Twenty-two chronically implanted rats were recorded. The median amount of REM during all three protocols was approximately 1 min. The deficits of median amount of NREM in minutes within the 3-h deprivation periods as compared with their baselines were, respectively for 2T1R, 1T2R, and 3R, 35 (43%), 25 (25%), and 7 (7%). Medians of REM rebound in the three succeeding hours, in minutes above baseline, were, respectively, 8 (44%), 9 (53%), and 9 (50%), showing no significant differences among protocols. Attempted transitions to REM showed a rising trend during REM deprivations reaching a final value that did not differ significantly among the three protocols. These results support the hypothesis that the build up of REM pressure and its subsequent rebound is primarily related to REM absence independent of the presence of NREM.

Animals↗

PubMed2006

Performance on a simple reaction time task while sleep deprived.

Divergent results have been reported on the effect of a night's sleep loss on performance of a single monotonous task. The present experiment examined the effect that partial sleep deprivation had on 10 participants' performance on a simple reaction time task requiring low responding for 120 min. compared to performance on the same task when well rested. Participants missed significantly more signals and had slower reaction times when sleep deprived. Reaction times increased with time when participants were both sleep deprived and rested, but the number of misses did not significantly change over time. Reaction time was significantly correlated with subjective ratings of sleepiness and heart rate in both conditions. EEG and heart-rate variability measures did not correlate significantly with reaction time. Misses correlated significantly with subjective ratings and heart rate but only in the rested condition.

Adult↗

PubMedDate not supplied

Sleep deprivation and epilepsy.

This review summarizes the data for and against sleep deprivation as a facilitator of epileptic seizures and interictal epileptiform discharges. Much of these data are derived from clinical studies; however, basic science investigations are greatly needed to determine the influence of sleep deprivation on seizure susceptibility and neuronal function. Study of the effects of sleep deprivation on epilepsy may create a window of opportunity that could help decipher how seizures are triggered and facilitated, potentially providing an avenue for future interventions.

Journal Article↗

PubMed1996

Circadian rhythms of prolactin and thyroid-stimulating hormone during the menstrual cycle and early versus late sleep deprivation in premenstrual dysphoric disorder.

The present study extended previous work by examining whether disturbances in the circadian rhythms of prolactin (PRL) and thyroid-stimulating hormone (TSH) distinguish patients with premenstrual dysphoric disorder (PMDD) from normal volunteers. In addition, the effects of therapeutic interventions with early and late partial sleep deprivation were explored. Both PRL and TSH levels were measured every 30 min from 18:00 h to 09:00 h during midfollicular and late luteal menstrual cycle phases in 23 PMDD patients and 18 normal volunteers. Hormone levels were measured again after a randomized crossover trial of early (sleep 03:00-07:00 h) versus late (sleep 21:00-01:00 h) partial sleep deprivation administered in two separate luteal phases. Compared with normal volunteers, PMDD patients had higher PRL concentrations, consistent with previous findings. TSH rhythms occurred earlier in PMDD than in normal subjects. PRL levels decreased and TSH levels increased with sleep deprivation compared with baseline conditions. The timing of PRL secretion shifted earlier with late sleep deprivation and later with early sleep deprivation. Although circadian disturbances of PRL and TSH were found in PMDD patients compared with normal volunteers, the therapeutic effects of early and late sleep deprivation do not appear to be mediated by correcting these disturbances.

Affect↗

PubMedDate not supplied

Magnetic fields mimic the behavioral effects of REM sleep deprivation in humans.

The discovery of rapid eye movement (REM) sleep by Aserinsky and Kleitman in 1953 initiated the impetus for sleep research and specifically the investigations of the effects of REM sleep deprivation (RSD) on animal and human behavior. The behavioral effects of RSD include the enhancement of motivational and "drive"-related behaviors. In laboratory animals, RSD has been reported to increase appetite, sexual behavior, aggressiveness, and locomotor activity. Moreover, RSD reportedly improves mood in patients with endogenous depression and heightens appetite and sexual interest in normal subjects. Since "drive"-related behaviors are thought to involve activation of limbic dopaminergic reward sites, RSD may enhance motivational behaviors through an action on limbic dopaminergic functions. In the present communication, we present two patients (one with multiple sclerosis and the other with Parkinson's disease) in whom treatment with magnetic fields produced behavioral effects which paralleled those observed in REM-sleep-deprived animals and humans. We propose, therefore, that the behavioral and mental effects of treatment with magnetic fields may be mediated via RSD and, by inference, involve activation of limbic dopaminergic reward sites.

Adult↗

PubMed2007

Cocaine-induced genital reflexes in paradoxical sleep deprived rats: Indications of mediation by serotonin receptors.

As paradoxical sleep deprivation (PSD) modifies cocaine-induced genital reflexes (penile erection [PE] and ejaculation [EJ]) and since cocaine is a serotonin (5-HT) reuptake inhibitor, we hypothesized that 5-HT also plays a role in these genital reflexes in PSD male rats. After a 4-day period of PSD each group was administered with serotonergic drugs prior to cocaine and placed in observation cages. The selective 5-HT(1) agonist (8-OH-DPAT) completely abolished PE events whereas the antagonist (pindolol) did not produce significant effects in the number of animals displaying PE. It was found that both drugs reduce the frequency of PE. There were no significant effects on the number of animals that ejaculated or in its frequency after pindolol although both parameters were reduced by the agonist at the highest doses (2 and 4 mg/kg, SC). Pretreatment with the 5-HT(2) agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (0.12; 0.5 and 1 mg/kg, SC) significantly reduced the number of rats displaying PE and all doses reduced both PE and EJ frequencies. The number of animals displaying PE after 5-HT(2) antagonist (ketanserin) pretreatment at 1 and 2.5 mg/kg doses was significantly decreased in relation to vehicle rats and all doses reduced PE frequency. 5-HT(2) compounds at any dose did not affect the number of animals ejaculating, but the frequency was significantly reduced by all doses of DOI and by 1 to 5 mg/kg doses of ketanserin. Taken together, the results suggest that serotonergic receptors play an important role in genital reflexes induced by cocaine in sleep deprived males.

Animals↗

PubMed2002

Sleep deprivation and junior doctors' performance and confidence.

PURPOSE OF STUDY: To determine whether sleep deprivation affects not only junior doctors' performance in answering medical questions but whether their ability to judge their own performance is also affected by lack of sleep. METHODS: A questionnaire based follow up study in two district general hospitals of the Carmarthenshire NHS Trust. Eleven house officers and 15 senior house officers (SHOs) within the medical directorate participating in the on-call rota were recruited between July 1999 and May 2000. RESULTS: SHOs answered significantly more questions correctly (p=0.04) and were more confident than house officers when they were either correct or incorrect (p<0.001). Length of unbroken or continuous sleep is associated with more correct answers (p=0.03) and higher energy (p=0.09) and confidence (p=0.07) scores self rated by the profile of mood states. Length of continuous sleep was not related to the appropriateness of confidence, as measured by the "within-subject confidence-accuracy correlation" (p=0.919). CONCLUSIONS: SHOs performed better than house officers even allowing for sleep loss. Sleep deprivation had adverse effects on mood and performance but junior doctors can still monitor their performance and retain insight into their own ability when sleep deprived.

Adult↗

PubMed2005

Effects of paradoxical sleep deprivation on the performance of rats in a model of visual attention.

In the present work we sought to evaluate the effects of paradoxical sleep deprivation (PSD) on the performance of rats in the five-choice serial reaction time task, a test designed to assess attentional function. Adult male Wistar rats were trained to detect a brief (1 s) light stimulus randomly presented in one of five locations in a box specially designed for the task. After achieving stable performance, the animals were submitted to 96 h of sleep deprivation by the platform technique, in which the rats are placed on top of small platforms in a tank filled with water. During sleep, particularly during the paradoxical stage, the loss of muscle tone make the animals fall into the water, thus awakening them and so depriving of sleep. Performance in the task was assessed daily during the 96 h deprivation period and also during seven recovery days afterwards. Paradoxical sleep deprivation reduced accuracy on the on the third (72 h) and fourth (96 h) days of sleep deprivation compared to home-cage controls, and this impairment reverted soon after the beginning of the recovery period. Sleep-deprived animals also showed an increase in omissions in the first day of PSD and a reduction on the number of trials started on the fourth day of sleep deprivation. No significant group differences were observed in premature and perseverative responses, correct response latency and reward latency. Our results thus indicate that paradoxical sleep deprivation impairs attentional function.

Animals↗

PubMed1991

The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography.

This study is the first report on the effects of total sleep deprivation (about 32 h) on regional cerebral glucose metabolism during wakefulness in man, using positron emission tomography (PET) with F-18 deoxyglucose (FDG). Sleep deprivation leads to a significant reorganization of regional cerebral metabolic activity, with relative decreases in the temporal lobes and increases in visual cortex. Absolute glucose metabolic measurements indicate a decrease in thalamus, basal ganglia, white matter, and cerebellum. No overall decrease in whole brain metabolism was noted after sleep deprivation. As expected, sleep deprivation significantly reduced visual vigilance as assessed by the continuous performance test and this decrease was correlated significantly with reduced metabolic rate in thalamic, basal ganglia, and limbic regions.

Adult↗