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At least 667 records · Page 37Linked to original sources
PubMed2006

[Association of polymorphic variants in endothelin-1 (EDN1) genes with the therapy of patients with cutaneous T-cell lymphomas].

BACKGROUND: The cutaneous T-cell lymphomas (CTCL) are diseases characterised by cutaneous infiltrates of malignant, clonally expanded T-cells. Because individual genetic determination of angiogenetic and antioxidant properties of blood vessels could take part in responsibility to phototherapy in CTCL patients, the association of two frequent polymorphisms in endothelin-1 gene with phototherapy was tested. METHODS AND RESULTS: 77 patients with CTCL, diagnosed and treated at the First Dermatological Clinic of St. Ann's Faculty Hospital Bmo (46 men and 31 women, median age 62, range 28-82 years) were included in the study. Diagnosis of CTCL according to the clinical picture was verified histologically. The genotype distributions and allelic frequencies between CTCL with phototherapy and those without phototherapy were compared. The 4A4A variant of -3A/-4A EDN1 is more frequent in patients treated with phototherapy (8/30 vs. 1/38, OR=10.13; P=0.01). The GA and AA genotypes of G8002A EDN1 polymorphism are more frequent in CTCL patients treated with phototherapy compared to those without it (15/23 vs. 7/32, OR=2.98; P=0.03). CONCLUSIONS: Some polymorphic variants in EDN1 genes, a homozygote -4A-4A in -3A/-4A EDN1 and genotypes GA and GG in G8002A EDN1) seem to carry an advantage for phototherapy effectiveness in patients with CTCL.

Adult↗
PubMedDate not supplied

[The effect of detoxifying hemosorptive hemosorption and physiotherapy on the immune status in acute exogenous poisoning].

Similar changes in cellular and humoral immunity indicative of the onset of toxic immune depression have been revealed in 53 patients with acute poisoning with organophosphorus insecticides and psychotropic agents. The therapy employed hemosorption (HS), blood exposure to magnetic field and ultraviolet (UV) blood irradiation. Immunocorrection was the most effective in the combination of HS with UL blood irradiation. The technique accelerated lymphocyte differentiation and stimulated metabolic activity of neutrophils. Blood exposure to magnetic field had no considerable effect on the immunity indexes.

Blood↗
PubMed1989

Ditrastick combined with UVB. An alternative regimen for plaque psoriasis.

Two comparable groups of 15 out-patients with symmetrical plaque psoriasis were included in an open right-left comparison study. Paraffin based, 3% dithranol (anthralin) sticks (Ditrastick), Orion Pharmaceutica, Espoo, Finland) and 0.5-1% dithranol in white petrolatum were used in combination with UVB. Both suberythema doses and MED doses were used and the effect of UVB-pretreatment was studied. Pretreatment with UVB and combination therapy with dithranol using suberythema doses of UVB seems to decrease dithranol irritation and shorten the treatment time. Preliminary results are given.

Anthralin↗
PubMed1987

[Carcinogenic risks of phototherapy and photochemotherapy].

The data in the literature regarding the carcinogenic risks involved in both UVB phototherapy and 8-methoxypsoralen plus UVA photochemotherapy are discussed. Both modes of treatment can be mutagenic and can induce immunosuppression. Which of the two factors (the initiator or the promoter effect) is more responsible for the carcinogenic risks involved in phototherapy or photochemotherapy is a subject of much controversy. In addition to discussing the theoretical background, the present article also takes into consideration the long-term clinical studies that have been performed. Practical guidelines are given on how to apply phototherapy and photochemotherapy as safely as possible.

Humans↗
PubMed1987

Effect of UVA and PUVA on alloactivating and antigen-presenting capacity of human epidermal Langerhans cells.

Human epidermal cell suspensions (EC), obtained with a suction blister technique and enzyme digestion, were irradiated with various doses of UVA with (PUVA) or without previous incubation with 8-methoxypsoralen (8-MOP). EC were then cocultured with allogeneic T cells or pulsed with the soluble antigen purified protein derivative of tuberculin (PPD) for 90 min before being cocultured with autologous T cells. While low doses of UVA induced a small but significant increase in the PPD-specific T-cell response, both PUVA and higher doses of UVA induced dose-dependent reductions. The allogeneic T-cell responses were reduced with PUVA, as well as with UVA, in a dose-dependent fashion. PUVA was far more effective than UVA in reducing both allogeneic and antigen-specific T-cell responses. There were no differences between numbers of DR-positive cells in EC before, immediately after or 24 h after PUVA or UVA radiation, and quantitative determination of EC HLA-DR molecules using an indirect radioimmunoassay (RIA) technique did not reveal any difference between PUVA-treated and non-irradiated cells.

Cells, Cultured↗
PubMed1982

Psoriasis treatment and a day-care centre: clinical aspects and an attempt at a cost-benefit analysis.

The practical results of day-care centre treatment of psoriasis have been studied. Patients referred to the centre are generally those where the skin disease covers substantial body areas. The main treatment has been UVB. UVB plus dithranol or PUVA has been used on patients who have failed to respond to UVB alone. With UVB therapy alone, 263/328 patients healed with a median to healing time of 8 weeks, and 9 weeks to relapse. 34/60 patients with a previously poor response to UVB healed on UVB plus dithranol. Median time to healing was 8 weeks and time to relapse, 12 weeks, 24 patients were treated with PUVA, as they had had a poor earlier response to UVB. All healed with a median time to healing of 12 weeks and 25 weeks to relapse. 3.3% of the patients fit for work have at some time during the treatment been off work due to their psoriasis. The cost for this type of treatment is about one-fifteenth of the cost of treatment on a hospital ward.

Adolescent↗
PubMed1980

[Experience with newer psoriasis therapies (author's transl)].

The following treatments for psoriasis are compared with each other: PUVA, UVB, retinoid 10-9359 alone and in combination with 4 mg triamcinolone or UVB. The best results were obtained with UVB alone and with the combination of UVB and retinoid. Based on a survey of various psoriasis therapies during the last 40 years, it is concluded that a final assessment of the value of a new therapy is only possible after some time.

Etretinate↗