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At least 685 records · Page 38Linked to original sources
PubMed1990

Morphology and immunoperoxidase studies of intestinal adenomatosis in the blue fox, Alopex lagopus.

In a blue fox farm about 300 of 400 weanling pups were affected with diarrhoea and prolapse of the rectum. About 40 pups died in an emaciated state after a few days of disease. Eight pups were submitted for examination. Pathological findings were restricted to the caecum, proximal colon and rectum, with occasional extension to the ileum. Affected areas revealed a thick and rigid intestinal wall, a narrow lumen and a thickened, wrinkled and sometimes ulcerated mucosa. Histologically, the mucosa showed long tortuous crypts outlined by a high pseudostratified epithelium which lacked goblet cells. Epithelial cells revealed increased basophilia, and mitoses were seen along the entire crypt length and in the surface epithelium. Silver impregnation showed curved organisms in the apical cytoplasm of the altered epithelial cells. Penetration of the muscularis mucosa by the altered epithelial cells was frequent. The avidin-biotin-immunoperoxidase complex (ABC) technique revealed positive organisms in the apical cytoplasm of altered epithelial cells, when rabbit antisera against different biotypes and serotypes of Campylobacter jejuni and Campylobacter coli were used. Antisera against Campylobacter sputorum subsp. muscosalis and Campylobacter hyointestinalis were negative.

Adenoma↗
PubMed1996

Equine adenocarcinomas of the large intestine with osseous metaplasia.

Large intestinal adenocarcinoma with osseous metaplasia was diagnosed in two horses, a 15-year-old standard bred gelding and a 9-year-old Haflinger mare. Clinically, both animals had displayed weight loss and anaemia. A presumptive diagnosis of abdominal neoplasia was made and the horses were humanely killed. At necropsy, the gelding and the mare were found to have ulcerated tumours growing into the lumen of the caecum and colon, respectively. In the mare, the mass extended through the mesocolon and was evident in the left dorsal and ventral colon. Histopathologically, the tumours consisted of well-differentiated cords of single-layered columnar to cuboidal epithelial cells. Mitotic figures were very uncommon. In both lesions, well-formed bony spicules and osteoid were present in the fibrovascular stroma. The tumours were well-demarcated from surrounding mucosal tissue but had invaded the intestinal wall. Metastases were not observed.

Adenocarcinoma↗
PubMed1996

Infantile intestinal leiomyosarcoma: surgical resection (without adjuvant therapy) for cure.

A 7-week-old boy presented with a 6-week history of failure to thrive, acute intestinal obstruction, and an apparently irreducible intussusception (noted on contrast enema). He underwent abdominal exploration, during which a cecal mass was identified and resected. The mass proved to be a leiomyosarcoma. Histologically, it was an intermediate-grade malignancy with a predicted 5-year survival rate of 16% to 23% based on data from the adult experience. Three years after resection and without having received adjuvant therapy, he is healthy and free of disease. A review of the literature showed that in infants these tumors are predominantly colonic, compared with the predilection for small intestinal lesions found in the older pediatric and adult populations. Infantile intestinal leiomyosarcomata are rare malignancies that do well if complete surgical excision of the disease can be accomplished. The histological prognostic indicators proposed for intestinal leiomyosarcomas in the adult population cannot be extrapolated to infants because when they occur in infants, they appear to be less aggressive, and these patients do well without adjuvant therapy.

Age of Onset↗
PubMed1990

Is evaluation of the right colon necessary prior to cecocystoplasty?

Use of the ileocecal bowel segment in urological surgery has become more widespread. Thorough preoperative evaluation of the bowel is seldom performed. A case is presented in which the intraoperative finding of numerous cecal polyps led to abortion of a planned cecocystoplasty. The literature on fecal occult blood testing and screening methods for colorectal neoplasia was reviewed. Patients are classified into 2 categories, average risk and high risk, according to the relative risk for colorectal neoplasia. The data suggest that the fecal occult blood test, if properly performed, is an adequate screening tool for average risk patients. However, because of the high rate of false negative results this test is inadequate for evaluation of high risk patients. It is recommended that such patients should undergo preoperative screening colonoscopy regardless of the fecal occult blood test result.

Aged↗
PubMed1995

Malignancy, mortality, and medicosurgical management of Clostridium septicum infection.

BACKGROUND: Necrotizing Clostridium septicum infections (CSI) have a strong association with malignancy or immunosuppression. To clarify this relationship and determine how it impacted mortality, the experience with CSI at a single institution was reviewed. METHODS: Records of all patients admitted to our hospital with culture proven clostridial infection from 1966 through 1993 were reviewed. RESULTS: Among patients presenting with clinical gas gangrene, 281 had culture proven clostridial infection and 32 (11.4%) had CSI. The mortality among CSI patients was 56%, whereas 26% of all patients with clostridial infections died (p = 0.001). An associated malignancy was found in 50% of patients with CSI, whereas this was seen in only 11% of patients with other clostridial infections (p = 0.0001 for CSI versus clostridial infection overall). The remaining patients with spontaneous CSI all had evidence of immunosuppression. CONCLUSIONS: The high mortality and likelihood of associated malignancy or hematologic disease underscore the importance of a high index of suspicion and the need to search for and treat associated conditions in all patients with CSI.

Adenocarcinoma↗
PubMed1986

Carcinoma of the cecum.

Carcinoma of the cecum occurs more often in older people and often produces few significant early symptoms. Proper detection and right hemicolectomy may give good results.

Aged↗
PubMed1981

Primary carcinoma of the cecum with uterine metastases.

We report an unusual case of a poorly differentiated signet ring cell type of adenocarcinoma of the cecum, rare in its own right, that had metastasized to the endometrium. The diagnosis was made on the basis of fractional uterine curettage. It is believed that this is the first case of such an unusual cecal carcinoma metastatic to the endometrium.

Adenocarcinoma↗
PubMed1981

Cholecystectomy and right-sided colon cancer: an epidemiological study.

The relation between prior cholecystectomy and right-sided colon cancer was investigated in a case-control study of 150 patients with histologically confirmed adenocarcinoma of the caecum or ascending colon and of two comparison groups. One comparison group consisted of 150 patients, matched for age, sex, and race, who had histologically confirmed adenocarcinoma of the descending or sigmoid colon and the other of 123 neighbourhood controls. Compared with left-sided cancer controls, the right-sided colon cancer cases had a relative risk of 1.87 for colon cancer after cholecystectomy. The relative risk was 1.86 when they were compared with the neighbourhood controls. When compared with both control groups relative risk was 1.77, with 95% confidence limits of 0.95 and 3.3 (p = 0.07). The increased risk of right-sided colon cancer after cholecystectomy may be associated with changes in biliary metabolism occurring after removal of a gall bladder.

Adenocarcinoma↗
PubMed2001

An hsr on chromosome 7 was shown to be an insertion of four copies of the 11q23 MLL gene region in an HIV-related lymphoma.

A 45-year-old male with AIDS presented with a cecal diffuse large B-cell lymphoma. Cytogenetic and flourescence in situ hybridization (FISH) studies revealed a complex karyotype with multiple aberrations that included a translocation, t(8;14) involving MYC on chromosome 14. This is specific to B-cell lymphomas. There were also frequently observed secondary changes such as chromosome 1 rearrangement leading to trisomy of 1q and loss of tp53 from the deleted chromosome 17. A unique secondary abnormality was an hsr on chromosome 7, which by FISH and SKY investigations was shown to originate from chromosome 11 involving 4 copies of the MLL gene region.

Cecal Neoplasms↗