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At least 685 records · Page 38Linked to original sources
PubMed1986

Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction.

Attempts were made to prepare antisera monospecific for Lp(a) lipoprotein and to investigate the distribution of subjects according to plasma levels of Lp(a) in Japanese controls and patients with coronary heart disease or cerebral infarction. Positive plasma reactions to the double diffusion test for Lp(a) (Ouchterlony) were observed in 32.3% of the healthy Japanese subjects, which is similar to results previously reported in western countries. The plasma threshold level of 17 mg/dl was considered an appropriate point for dividing subjects into positive and negative groups depending on reactions to the double diffusion test. When subjects were divided into two groups at 17 mg/dl, a significant association was found between a high plasma level of Lp(a) and either coronary heart disease or cerebral infarction in the distribution of the cortical artery. These results suggest that Lp(a) may play an important part as a risk factor for coronary heart disease and cerebral infarction.

Aged↗
PubMed1985

[Correlation between the severity of atherosclerosis of cerebral, coronary and retinal vessels].

As a result of clinico-physiological examinations 643 patients suffering from cerebral atherosclerosis were divided into 3 groups by the severity of atherosclerosis of the cerebral vessels. These patients also exhibited atherosclerosis of the coronary and retinal vessels. Mathematical methods have been used to study the relationship and severity of atherosclerosis of the cerebral, coronary and retinal vessels. The findings obtained indicate that despite a systemic nature of the atherosclerotic process the involvement of various vascular areas is individual and asynchronous. With the development of cerebral atherosclerosis its correlation with atherosclerosis of other localizations becomes closer.

Adult↗
PubMedDate not supplied

Apolipoprotein B (apoB) retention in atherosclerotic intracranial arteries.

Low (LDL) and very low (VLDL) density lipoproteins retained in grossly normal and atherosclerotic human intracranial arteries have been quantitated using an electro-immunoassay directed against apolipoprotein B (apoB), the major protein of these two lipoprotein fractions. Buffer-homogenates of grossly normal arteries contained apoB amounts ranging from less than 0.04 to 1.58 microng/mg tissue dry weight, while those of atherosclerotic plaques gave values ranging from 0.80 to 3.9 microng per mg tissue dry weight. These results were consistent with immunofluorescence studies localizing apoB in these arteries. Plaques also contained a remaining fraction of tightly-bound apoB as evidenced by positive immunofluorescence in sections of pellets from buffer homogenates. This was in contrast to the negative results from grossly normal arteries. These results would suggest that retention of apoB by intracranial arteries correlates positively with vessel lesions. Arterial apoB is present in both grossly normal regions and plaques in a loosely-bound form, possibly representing intact lipoprotein. ApoB is also present in a tightly-bound form in plaques.

Adolescent↗