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Enhancement of video images.

The enhancement of radiographic and fluoroscopic images using simple video analog techniques is described. In each instance, both the degree of enhancement and the features of the image to be enhanced are under the direct control of the radiologist. Noise is suppressed with a sharp cut-off, low-pass filter. Three types of analog circuits are discussed. One provides edge sharpening and contrast enhancement; one allows either black or white suppression, with expansion of the remaining shades of gray; and one provides an exponential response to selectable portions of the input signal.

Computers, Analog↗

Thermal conductivity and heat transfer of the human skin.

In all problems involving heat transfer in the human body or to the environment the thermal conductivity of the tissues, especially that of the epidermis, plays an important role. Quantitatively, however, regarding the required resolutions in time and/or space, the problems associated with the overall thermoregulation are quite different from those relating to local skin circulation. This has been discussed be referring to models designed to study the thermoregulation, electrical analogs representing also local skin areas and a number of examples. It was suggested that it is worthwhile to investigate high-resolution thermography as a useful tool for calibrating locally applied probes to measure skin blood flow.

Body Temperature Regulation↗

Digital image management: networking, display, and archiving.

The requirements for implementing a radiology imaging network are similar to those for local area networks now being designed for other purposes to manage large data films. A radiology department serving a 500-bed hospital generates about 927 megabytes of digitally formatted data per working day. These data are expected to be on line for the patient's hospitalization period. The retrieval rate of these data among the interactive diagnosis display stations requires data throughput rates of between 2 and 5 megabits per second. This throughput rate requires signaling rates of between 20 and 50 megabits per second. Analog hard-copy generation of the images on the network is required by the referring physician for selected images that support the consultation report. Digital laser recorders using paper may be quite satisfactory. Long-term archiving must be low in cost and requires a database scheme capable of managing more than a terabyte of image data. Radiology networks must be required to bridge with other hospital information systems.

Computers↗

An analog approach to measuring O2 uptake on-line.

An analog circuit has been designed to provide a solution to the Haldane transformation that yields true O2 fraction. Incoming signals proportional to fractional concentration of CO2 and O2 in mixed expired gas are utilized in the circuit and the results are multiplied by a value proportional to ventilation. The final products are analog signals proportional to O2 uptake and CO2 output. The system is applicable to the anesthetized and paralyzed animal kept at a known constant ventilation. The final products are analog signals proportional to O2 uptake and CO2 output. The system is applicable to the anesthetized and paralyzed animal kept at a known constant ventilation. Diagrams of the circuit and expired gas collection and analysis arrangements are provided.

Animals↗

An analog VLSI implementation of a visual interneuron: enhanced sensory processing through biophysical modeling.

Flies are capable of rapid, coordinated flight through unstructured environments. This flight is guided by visual motion information that is extracted from photoreceptors in a robust manner. One feature of the fly's visual processing that adds to this robustness is the saturation of wide-field motion-sensitive neuron responses with increasing pattern size. This makes the cell's responses less dependent on the sparseness of the optical flow field while retaining motion information. By implementing a compartmental neuronal model in silicon, we add this "gain control" to an existing analog VLSI model of fly vision. This results in enhanced performance in a compact, low-power CMOS motion sensor. Our silicon system also demonstrates that modern, biophysically-detailed models of neural sensory processing systems can be instantiated in VLSI hardware.

Algorithms↗

On a non linear describing function for bio-data.

The behaviour and handling of a flexible three variable--parameter function is presented, which is suitable for unbiased regression analysis. The function is defined by an intercept, a slope or coefficient and an exponent on the independent variable. Analog and digital problems and solutions are defined. Handling is simple and the program is run without operator intervention. The range of curves include linear, convex, concave and asymptotic forms and can be extended to include sigmoid and parabolic forms. Some application results are presented for different situations.

Computers↗

Urodynamic modeling of norfloxacin pharmacokinetics by means of computer simulation.

Urodynamic model was developed which, in conjunction with a compartmental pharmacokinetic model, was used for study of factors influencing drug concentrations in urine: urine flow rate, residual bladder urine, maximal bladder urine, stage of renal failure, and elimination kinetics of drugs. Norfloxacin (NOR) was used as a model drug, although the model haw general applicability for all urinary antiseptics. Pharmacokinetic data were obtained from a clinical study in which norfloxacin was administered orally as a single 400mg dose to four subjects with installed urine catheters. Sample of blood, bladder and catheter urine were collected and concentrations of NOR measured by a HPCL method. Modeling was performed on analog--hybrid computer EAI 580. Besides the fitting of model response to obtained in vivo data, simulations of expected clinical situations were performed in which the interplay of above mentioned factors was studied in terms of urine concentrations profiles. NOR treatment with 400mg b.i.d. secured sufficient urine concentrations in most studied cases. This approach should be applied for corresponding study of other urinary antiseptics, especially those with less favourable urinary levels.

Chromatography, High Pressure Liquid↗

An analog VLSI chip emulating polarization vision of Octopus retina.

Biological systems provide a wealth of information which form the basis for human-made artificial systems. In this work, the visual system of Octopus is investigated and its polarization sensitivity mimicked. While in actual Octopus retina, polarization vision is mainly based on the orthogonal arrangement of its photoreceptors, our implementation uses a birefringent micropolarizer made of YVO4 and mounted on a CMOS chip with neuromorphic circuitry to process linearly polarized light. Arranged in an 8 x 5 array with two photodiodes per pixel, each consuming typically 10 microW, this circuitry mimics both the functionality of individual Octopus retina cells by computing the state of polarization and the interconnection of these cells through a bias-controllable resistive network.

Algorithms↗

Directional harmonic theory: a computational Gestalt model to account for illusory contour and vertex formation.

Visual illusions and perceptual grouping phenomena offer an invaluable tool for probing the computational mechanism of low-level visual processing. Some illusions, like the Kanizsa figure, reveal illusory contours that form edges collinear with the inducing stimulus. This kind of illusory contour has been modeled by neural network models by way of cells equipped with elongated spatial receptive fields designed to detect and complete the collinear alignment. There are, however, other illusory groupings which are not so easy to account for in neural network terms. The Ehrenstein illusion exhibits an illusory contour that forms a contour orthogonal to the stimulus instead of collinear with it. Other perceptual grouping effects reveal illusory contours that exhibit a sharp corner or vertex, and still others take the form of vertices defined by the intersection of three, four, or more illusory contours that meet at a point. A direct extension of the collinear completion models to account for these phenomena tends towards a combinatorial explosion, because it would suggest cells with specialized receptive fields configured to perform each of those completion types, each of which would have to be replicated at every location and every orientation across the visual field. These phenomena therefore challenge the adequacy of the neural network approach to account for these diverse perceptual phenomena. I have proposed elsewhere an alternative paradigm of neurocomputation in the harmonic resonance theory (Lehar 1999, see website), whereby pattern recognition and completion are performed by spatial standing waves across the neural substrate. The standing waves perform a computational function analogous to that of the spatial receptive fields of the neural network approach, except that, unlike that paradigm, a single resonance mechanism performs a function equivalent to a whole array of spatial receptive fields of different spatial configurations and of different orientations, and thereby avoids the combinatorial explosion inherent in the older paradigm. The present paper presents the directional harmonic model, a more specific development of the harmonic resonance theory, designed to account for specific perceptual grouping phenomena. Computer simulations of the directional harmonic model show that it can account for collinear contours as observed in the Kanizsa figure, orthogonal contours as seen in the Ehrenstein illusion, and a number of illusory vertex percepts composed of two, three, or more illusory contours that meet in a variety of configurations.

Brain↗

Correlations between cephalometric and facial photographic measurements of craniofacial form.

INTRODUCTION: The purpose of this study was to compare craniofacial measurements from cephalometric radiographs with analogous measurements from standardized facial photographs. METHODS: The sample consisted of 326 subjects (168 white, 158 black) enrolled in a genetic epidemiological family study of sleep behavior. Traditional lateral cephalograms and standardized facial photographs were taken of each subject. Three angular, 3 linear, total face height, and lower face height cephalometric measurements were compared with 4 angular and 4 linear measurements from standardized photographs. Descriptive statistics for all measurements in the entire sample and for the racial subgroups were computed. Pearson product moment correlation coefficients were computed between analogous measurements, and intraclass correlation coefficients were calculated from repeated measurements on the photographs. RESULTS: The reliability of the photographic technique was excellent, with all measurements having intraclass correlation coefficients above 0.90. However, the correlations between analogous photographic and cephalometric measurements were lower and varied between 0.356 and 0.643. The highest correlations were observed for lower facial height and mandibular length, 0.643 and 0.562, respectively. In the black group, the correlations between cephalometric and photographic measurements of mandibular length and lower facial height were 0.676 and 0.690, respectively. Both were higher than those for white subjects, 0.399 and 0.577, respectively. CONCLUSIONS: Both linear and angular measurements useful for characterizing facial morphology can be reliably measured from facial photographs. However, only moderate correlations with analogous cephalometric measures were found. Therefore, standardized photographs and cephalograms most likely measure different aspects of facial morphology and cannot be used interchangeably. Cephalometrics remains the method of choice for clinical patient care, whereas photographs might be better for large-scale epidemiological studies, especially if there is a need for a low-cost, noninvasive method that be used in diverse clinical and field settings.

Black People↗

Localization of thermal packets and metastable states in the Sinai model.

We consider the Sinai model describing a particle diffusing in a one-dimensional random force field. As shown by Golosov, this model exhibits a strong localization phenomenon for the thermal packet: all thermal trajectories starting from the same initial condition in the same sample remain within a finite distance of each other even in the limit of infinite time. More precisely, he has proved that the disorder average P(t)(y) of the distribution of the relative distance y=x(t)-m(t) with respect to the (disorder-dependent) most probable position m(t), converges in the limit t--> infinity, towards a distribution P(G)(y) defined as a functional of two independent Bessel processes. In this paper, we revisit this question of the localization of the thermal packet. We first generalize the result of Golosov by computing explicitly the joint distribution P( infinity )(y,u) of relative position y=x(t)-m(t) and relative energy u=U(x(t))-U(m(t)) for the thermal packet. Next, we compute the localization parameters Y(k), representing the disorder-averaged probabilities that k particles of the thermal packet are at the same place in the infinite-time limit, and the correlation function C(l) representing the disorder-averaged probability density that two particles of the thermal packet are at a distance l from each other. We, moreover, prove that our results for Y(k) and C(l) exactly coincide with the thermodynamic limit L--> infinity of the analog quantities computed for independent particles at equilibrium in a finite sample of length L. So even if the Sinai dynamics on the infinite line is always out-of-equilibrium since it consists in jumps in deeper and deeper wells, the particles of the same thermal packet can nevertheless be considered asymptotically as if they were at thermal equilibrium in a Brownian potential. Finally, we discuss the properties of the finite-time metastable states that are responsible for the localization phenomenon and compare with the general theory of metastable states in glassy systems, in particular as a test of the Edwards conjecture.

Journal Article↗

Inexpensive analog equipment for processing gas chromatography mass spectrometry data.

Using relatively simple analog circuitry, and an inexpensive analog frequency modulated tape recorder (or a modified audio recorder) for data storage, repetitively scanned spectra may be examined on an oscilloscope, and reconstructed mass chromatograms produced. The same equipment may be used for peak matching, and for selective ion detection over the full mass range of a sector instrument.

Chromatography, Gas↗

Microcomputer control of behavior and the acquisition of digital and analog data.

Advances in technology and decreasing costs are enabling microcomputers to displace more traditional devices in the scientific laboratory. The availability of various approaches to software-system development for the use of microcomputers in the on-line control of experiments has contributed to the trend. This report describes a software system developed to control conditioned behavior during schedules of reinforcement while simultaneously accumulating behavioral data and physiological (analog) data using a hardware system base on the Radio Shack TRS-80 Model I microcomputer. The software utilizes a high-level interpretive language (Microsoft BASIC), assembly language and compiled BASIC to attain an acceptable execution speed and ease of programming.

Animals↗

Analog processing of vestibular nystagmus for on-line cross- correlation data analysis.

An analog processing circuit is described which allow accurate measurement of the phase relationships between input angular acceleration and resulting eye velocity. Vestibular nystagmic data are processed via analog technics to yield slowphase eye velocity. The turntable velocity input is cross-correlated with the eye velocity output, using a Nicolet MED-80 minicomputer system. The resulting correlograms are further processed to obtain precise phase information. Test data analysis shows a system resolution within 1 degree. Data from human and animal subjects are portrayed.

Acceleration↗

An analog device to facilitate occlusion pressure measurements.

The "oclusion pressure" technique is widely used to test the response of respiratory centers to CO2. The graphic treatment of the test necessitates a fast recording of the mouth pressure signal, thus using a great deal of paper and requiring a tedious interpretation. The device described here controls an electromagnetic valve closing it during expiration and opening it after a given time delay, following the onset of inspiration. During that time only, the mouth pressure signal goes through an analog switch, the highest signal value is then equal to the occlusion pressure. This device allows the use of a slow recorder without loss of information. In addition, it has the advantage of generating very short respiratory occlusions, thus sparing the subject being tested from interferences in subsequent respiratory cycles. It can be used as a pretreatment unit to be associated with a microprocessor.

Carbon Dioxide↗

Clinical evaluation of Tc-99m N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate as a replacement for I-131 hippurate: concise communication.

A clinical comparison of Tc-99m N,N'-bis( mercaptoacetyl )-2,3- diaminopropanoate (Component A) (Tc-99m CO2-DADS-A) and I-131 hippurate was conducted in a series of five normal volunteers and 18 patients. Each subject was studied in one session with Tc-99m CO2-DADS-A and I-131-hippurate; digital and analog images were recorded for 30 min and after voiding. In the normal volunteers, digital images with Tc-99m CO2-DADS-A gave a kidney-to-background ratio at 3 min that was greater relative to I-131 hippurate, a leading-edge parenchymal transit time that was similar to I-131 hippurate, and a percent injected dose in the urine at 30 min that was slightly less than I-131 hippurate (p less than 0.05). In patients (serum creatinine 1.0 to 14.3 mg/dl), decreasing renal function impaired excretion of Tc-99m CO2-DADS-A more than that of I-131 hippurate (p less than 0.01). In analog images, Tc-99m CO2-DADS-A always gave superior spatial resolution. No evidence of hepatobiliary excretion was detected with either radiopharmaceutical. We conclude that Tc-99m CO2-DADS-A and similar compounds should be pursued as possible replacements for I-131 hippurate.

Alanine↗

The effects of an electric field on soluble collagen.

Electric birefringence decay curves of collagen suspended in aqueous buffered media were plotted as functions of pulse width and amplitude. They were then resolved into two components by means of an analog simulator. When these data were combined with the results of repeated pulsing, it was shown that an electric field promotes aggregation of collagen, although the variety of aggregate sizes falls within a fixed range. Observations of electric birefringence of dissolved collagen preparations as a function of ionic strengths tend to indicate that the bonding that occurs in an electric field is electrostatic.

Birefringence↗

Stochastic resonance in a single neuron model: theory and analog simulation.

Here, we consider a noisy, bistable, single neuron model in the presence of periodic external modulation. The modulation induces a correlated switching between states driven by the noise. The information flow through the system, from the modulation, or signal, to the output switching events, leads to a succession of strong peaks in the power spectrum. The signal-to-noise ratio (SNR) obtained from this power spectrum is a measure of the information content in the neuron response. With increasing noise intensity, the SNR passes through a maximum: an effect which has been called stochastic resonance, and which was first advanced as a possible explanation of the observed periodicity in the recurrences of the Earth's ice ages. We treat the problem within the framework of a recently developed approximate theory, valid in the limits of weak noise intensity, weak periodic forcing and low forcing frequency, for both additive and multiplicative noise. Moreover, we have constructed an analog simulator of the neuron which demonstrates the stochastic resonance effect, and with which we have measured the SNRs for comparison with the theoretical results. Our model should be of interest in situations where a single inherently noisy neuron is the receptor of a periodic signal, which is itself noisy, either from the network or from an external source.

Animals↗