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At least 685 records · Page 38Linked to original sources
PubMed1998

Mapping the source and character of pain due to endometriosis by patient-assisted laparoscopy.

STUDY OBJECTIVE: To determine by patient-assisted laparoscopy (PAL) the relationship of lesions of endometriosis to pelvic pain. DESIGN: Prospective non-randomized study (Canadian Task Force classification II-1). SETTING: University based facility. PATIENTS: Fifty women with endometriosis. INTERVENTION: Lesions of endometriosis were examined as to color and size, and these areas were mapped for pain. MEASUREMENTS AND MAIN RESULTS: Lesions in all categories of colors and shapes were palpated. In lesions that did provoke a pain response, red and vascular lesions were most painful, followed by clear and white scar lesions. Least painful were black lesions. Pain extended beyond lesions to normal-looking peritoneum for up to 27 mm, but was not consistent with respect to type of lesion. CONCLUSION: Pain of endometriosis has little relationship to location or color of lesions. It can extend beyond visible lesions to normal peritoneum. Input from patients by PAL may be essential to achieve successful therapy and eliminate excessive surgery and risk.

Adolescent↗
PubMed2001

Estimation of antithyroid drug dose in Graves' disease: value of quantification of thyroid blood flow with color duplex sonography.

The purpose of this study was to evaluate if there is an association between the antithyroid drug dose that is needed to establish euthyroidism and thyroid blood flow measurements. A total of 23 Graves' disease patients with euthyroidism taking antithyroid drug therapy were enlisted to undergo spectral duplex sonography of the thyroid arteries and color-flow mapping of the thyroid gland. Color pixel density (CPD) was calculated with computer assistance from the color-flow maps. There was a strong correlation between the CPD and methimazole dose (rp = 0.79). Methimazole maintenance dosage could be predicted from CPD values with a coefficient of determination of 0.62. In conclusion, CPD measurements could be a useful tool for the clinical endocrinologist to estimate the antithyroid drug dose that is needed to maintain euthyroidism.

Adult↗
PubMedDate not supplied

Collagen birefringence in skin repair in response to red polarized-laser therapy.

We use the optical path difference (OPD) technique to quantify the organization of collagen fibers during skin repair of full-thickness burns following low-intensity polarized laser therapy with two different polarization incidence vectors. Three burns are cryogenerated on the back of rats. Lesion L(parallel) is irradiated using the electric field vector of the polarized laser radiation aligned in parallel with the rat's occipital-caudal direction. Lesion L(perpendicular) is irradiated using the electric field vector of the polarized laser radiation aligned perpendicularly to the aforementioned orientation. Lesion C is untreated. A healthy area labeled H is also evaluated. The tissue samples are collected and processed for polarized light microscopy. The overall finding is that the OPD for collagen fibers depends on the electric field vector of the incident polarized laser radiation. No significant differences in OPDs are observed between L(parallel) and H in the center, sides, and edges of the lesion. Lesions irradiated using the electric field vector of the polarized laser radiation aligned in parallel with the rat's occipital-caudal direction show higher birefringence, indicating that collagen bundles in these lesions are more organized.

Birefringence↗
PubMed1997

Uterine perfusion and endometrial thickness in postmenopausal women on long-term continuous combined estrogen and progestogen replacement.

We assessed the resistance index (RI) and pulsatility index (PI), peak and average systolic velocities in uterine, arcuate and radial arteries, and endometrial thickness (ET) by transvaginal B mode and color Doppler sonography in patients on continuous combined hormonal replacement therapy (HRT) and controls. HRT consisted of 2 mg estradiol, 1 mg estriol and 1 mg norethisterone acetate daily (n = 33) compared to controls, who received none of these (n = 21). Age was 61 +/- 6 and 59 +/- 9 years (mean +/- standard deviation) in the HRT and control groups, respectively. The duration of HRT was 5 +/- 2 years, with a minimum of 1 year. We found that the uterine RI and, to a lesser extent, the uterine PI were significantly lower and the radial peak systolic velocities were significantly higher in the HRT group compared to controls. The highest uterine PI values were measured in controls with the shortest life-time exposure to endogenous estrogens, i.e. late menarcheal age or early menopause. The endometrial thickness of 2.8 +/- 1.8 mm in the HRT group was not significantly different from that in the controls (4.2 +/- 5.6 mm). In conclusion, the alteration in blood flow parameters demonstrated in this study would suggest that the long-term use of continuous oral estradiol 2 mg, estriol 1 mg and norethisterone acetate 1 mg daily is associated with a slight increase of flow in the uterine arteries compared to controls matched for (postmenopausal) age. Endometrial thickness does not increase with duration of use of continuous combined HRT.

Adult↗
PubMedDate not supplied

[Effect of fezam on ocular dynamics in patients with senile macular degeneration].

The complex treatment in 25 patients with non-exudative forms of senile macular degeneration (ARMD) included the use of the nootropic agent fezam. Better visual acuity after a course of therapy was noted in 76% of the eyes of patients with ARMD. Color Doppler mapping prior to treatment indicated that all the patients had a significant reduction in the maximum systolic and end-diastolic blood flow velocities (Vs and Vd, respectively), and the increased peripheral resistance index (RI) in the ophthalmic artery, central artery of the retina, and short posterior ciliary arteries as compared to the normal values. Higher ophthalmic arterial blood flow velocities after a course of therapy are indicative of better blood supply to the tunics of the eye, which is a favorable sign for the prognosis of the disease. The use of fezam is effective in the complex therapy of non-exudative forms of senile macular degeneration.

Cinnarizine↗
PubMed1994

Recurrent cervical lymphadenopathy: differential diagnosis with color-duplex sonography.

In this prospective study 45 patients with cervical lymphadenopathy treated by operation, radiation and/or chemotherapy were examined by color-duplex sonography. The aim was to investigate the lymph node perfusion and to find out whether differentiation between benign and malignant nodal disease after therapy was possible by resistance and pulsatility indices. In 200 of 245 lymph nodes (82%) color-duplex sonography was able to detect perfusion. Using a pulsatility index (PI) threshold of 1.6 and resistance index (RI) threshold of 0.8, differentiation between reactive nodal enlargement and metastases was possible with an accuracy of 96%. Differentiation between lymphomas and metastases by RI and PI was not possible. Qualitative assessment of perfusional patterns was useful in detecting malignancy because reactively enlarged nodes showed greater hilar perfusion whereas metastases showed an increased peripheral perfusion. Lymphomas had both increased central and peripheral perfusions.

Adipose Tissue↗
PubMed1998

Bartonella henselae neuroretinitis in cat scratch disease. Diagnosis, management, and sequelae.

OBJECTIVE: This study aimed to report the long-term outcomes of patients treated with an antibiotic drug combination for Bartonella henselae neuroretinitis. DESIGN: The study design was a retrospective case series. PARTICIPANTS: Seven consecutive patients with neuroretinitis and cat scratch disease participated. INTERVENTIONS: Patients underwent medical and ophthalmic evaluations. Blood cultures were obtained, and B. henselae antibody titers were measured. Tuberculosis, Lyme, toxoplasmosis, syphilis, and sarcoidosis were excluded. Patients received oral doxycycline 100 mg and rifampin 300 mg twice daily for 4 to 6 weeks and were observed for an average of 16 months (range, 10-24 months). Formal electrophysiologic testing was performed in three patients after resolution of neuroretinitis. MAIN OUTCOME MEASURES: The changes in ocular inflammation and visual function associated with treatment were recorded. Follow-up examinations and electrophysiologic testing documented sequelae. RESULTS: Patients presented following cat exposure with fever, malaise, and blurred vision. Decreased visual acuity (ranging from 20/40 to counting fingers) frequently was associated with dyschromatopsia and afferent pupillary defects. Ophthalmoscopic analysis showed signs of neuroretinitis, including nerve fiber layer hemorrhages, cotton-wool spots, multiple discrete lesions in the deep retina, and stellate macular exudates. B. henselae infection was confirmed with positive blood cultures or elevated immunofluorescent antibody titers or both. Therapy appeared to promote resolution of neuroretinitis, restoration of visual acuity, and clearance of bacteremia. After 1 to 2 years, two eyes had residual disc pallor, afferent pupillary defects, retinal pigmentary changes, and mildly decreased visual acuity. Electrophysiologic studies showed that when compared to the fellow eye, affected eyes had subnormal contrast sensitivity, abnormal color vision, and abnormal visually evoked potentials. Conversely, electroretinograms were normal in all subjects. CONCLUSIONS: B. henselae is a cause of neuroretinitis in cat scratch disease. Compared to historic cases, doxycycline and rifampin appeared to shorten the course of disease and hasten visual recovery. Long-term prognosis is good, but some individuals may acquire a mild postinfectious optic neuropathy.

Adult↗
PubMed2000

DIAS I: duplex-sonographic assessment of the cerebrovascular status in acute stroke. A useful tool for future stroke trials.

BACKGROUND AND PURPOSE: A number of controlled trials have evaluated the benefit of intravenous thrombolysis in acute stroke with inconsistent results. None of these studies assessed the initial vascular status or provided information regarding the recanalization rate after therapy. Further trials need to clarify whether certain subgroups might possibly benefit more than others from intravenous thrombolysis. Therefore, a fast and valid method for assessment of cerebrovascular status is needed. In this multicenter study, we evaluated the potentials and limitations of color-coded duplex sonography (TCCS) for cerebrovascular status assessment in acute stroke patients before and after therapy. Furthermore, we compared the recanalization rate for patients referred to thrombolytic and conservative medical therapy. METHODS: Fifty-eight patients suffering from hemispheric stroke were enrolled consecutively in 8 centers. Duplex sonography was performed on admission, 2 hours after start of therapy, and 24 hours after onset of symptoms. Therapy was started within 6 hours. RESULTS: Intravenous thrombolysis was performed in 18 patients, conservative medical therapy in 39 patients, and early thromboendarterectomy in 1 patient. The middle cerebral artery (MCA) mainstem was patent in 29 patients (53.7%), occluded in 25 (46.3%), and was not assessable in 4 patients. Recanalization of the occluded MCA after 2 and 24 hours was diagnosed in 50% and 78% of the patients treated with rtPA and in 0% and 8% in the conservatively treated patients. CONCLUSIONS: Intravenous thrombolysis is highly effective in restoring blood flow after MCA occlusion. TCCS is suitable for assessment of the cerebrovascular status in acute stroke and therefore might define therapeutically relevant subgroups of patients in future stroke trials on the basis of their vascular pathology.

Adult↗
PubMed1985

Trans-spectral organic dye laser photocoagulation.

Clinical research utilizing the yellow, orange, and red wavelengths of the dye laser (Rhodamine 6G and MD-631) appears to have considerable promise and may demonstrate that the liquid organic dye laser is the laser of choice for photocoagulation of many types of ocular defects. The effectiveness of the dye laser as a photocoagulation source is due to the trans-spectral availability of relatively high output power wavelengths. Therefore, a target tissue can be selectively coagulated with minimal laser energy transmitted through the refractive media and minimal damage to nearby normal tissues. The dye laser, as a photocoagulation system, should prove valuable in the therapy of many ocular diseases.

Angiomatosis↗