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Neonatal adrenal hemorrhage detected antenatally.

This report describes two cases of neonatal adrenal mass detected antenatally by routine ultrasound (US) examination of pregnant women. Case 1 was recognized by the fetal US at 31 weeks gestation. The mass, located near the right upper pole of the kidney, was echolucent on US examination. A serial US of the mass showed changes of the internal echoes from a cystic lesion to a mixed lesion, and finally to a hyperechogenic lesion due to a neonatal adrenal hemorrhage (NAH). At 33 days, laparotomy was performed, and the pathological finding revealed an NAH owing to the mass bleeding into the adrenal cyst. Case 2 was also detected by fetal US just before birth. The mass of the right upper pole of the kidney was hyperechogenic on US examination. The baby clinically deteriorated after birth because of hypovolemia owing to NAH. A serial US of the mass showed the change from a hyperechogenic to a cystic lesion. Four months later, the mass spontaneously resolved. From the US spectrum, the mass was diagnosed as NAH. These are the second known cases of NAH detected before birth in Japan.

Adrenal Gland Diseases↗

Vasa Praevia.

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Blood Transfusion↗

Retinal haemorrhages in the newborn.

The present study shows the frequency and severity of retinal haemorrhages in 200 newborn, of which 100 were delivered spontaneously, 51 delivered by vacuum extractor and 49 by forceps. The incidence of retinal haemorrhages was highest in the vacuum group (50%), lowest in the forceps group (16%), while the spontaneously delivered children showed an incidence of 41%. The incidence of severe retinal haemorrhages was about five times higher in the vacuum group than in both forceps and control groups. The authors propose a quantitative grading of the haemorrhages. The purpose has been to obtain a better way of relating the haemorrhages to mode of delivery and probably also to relate retinal haemorrhages to possible brain damage.

Breech Presentation↗

Cardiac ECMO for biventricular hearts after paediatric open heart surgery.

OBJECTIVE: To delineate predictors of hospital survival in a large series of children with biventricular physiology supported with extracorporeal membrane oxygenation (ECMO) after open heart surgery. RESULTS: 81 children were placed on ECMO after open heart surgery. 58% (47 of 81) were transferred directly from cardiopulmonary bypass to ECMO. Hospital survival was 49% (40 of 81) but there were seven late deaths among these survivors (18%). Factors that improved the odds of survival were initiation of ECMO in theatre (64% survival (30 of 47)) rather than the cardiac intensive care unit (29% survival (10 of 34)) and initiation of ECMO for reactive pulmonary hypertension. Important adverse factors for hospital survival were serious mechanical ECMO circuit problems, renal support, residual lesions, and duration of ECMO. CONCLUSIONS: Hospital survival of children with biventricular physiology who require cardiac ECMO is similar to that found in series that include univentricular hearts, suggesting that successful cardiac ECMO is critically dependent on the identification of hearts with reversible ventricular dysfunction. In our experience of postoperative cardiac ECMO, the higher survival of patients cannulated in the operating room than in the cardiac intensive care unit is due to early effective support preventing prolonged hypoperfusion and the avoidance of a catastrophic cardiac arrest.

Cardiopulmonary Bypass↗

Microvasculature in germinal matrix layer: its relationship to germinal matrix hemorrhage.

Microvasculature in the germinal matrix layer (GML) was studied by postmortem microangiography and stereomicroscopic observation on cleared specimens in methyl salicylate. A number of arterioles from penetrating and medullary branches of main cerebral arteries were distributed in the GML, forming a fine network of arterioles anastomosing with each other. Many venules in the GML converged at a few points and drained into subependymal veins. The main converging zone of venules was situated inside the GML close to the border zone of the GML and adjacent cerebral parenchyma. The converging zone coincided with the site of GML hemorrhage. Thus, many factors, including both venous and arterial, appear to influence circulation in the GML; ultimately the converging zones become overloaded and rupture, leading to GML hemorrhage.

Angiography↗

Haemorrhagic claw lesions in newborn piglets due to selenium toxicosis during pregnancy.

In a sow herd piglets were born with haemorrhagic lesions on the proximal wall and sole of the claws of all their feet due to abnormal horn formation. High concentrations of selenium were detected in the liver and kidney of the piglets and appeared to be associated with these lesions. A selenium rich premix added to the rations of the sows in the second half of gestation was the origin of this selenium intoxication.

Animals↗