PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “ILEITIS, REGIONAL”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 685 records · Page 38Linked to original sources
PubMed1998

Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.

To investigate the roles of astroglial cells, we targeted their ablation genetically. Transgenic mice were generated expressing herpes simplex virus thymidine kinase from the mouse glial fibrillary acidic protein (GFAP) promoter. In adult transgenic mice, 2 weeks of subcutaneous treatment with the antiviral agent ganciclovir preferentially ablated transgene-expressing, GFAP-positive glia from the jejunum and ileum, causing a fulminating and fatal jejuno-ileitis. This pathology was independent of bacterial overgrowth and was characterized by increased myeloperoxidase activity, moderate degeneration of myenteric neurons, and intraluminal hemorrhage. These findings demonstrate that enteric glia play an essential role in maintaining the integrity of the bowel and suggest that their loss or dysfunction may contribute to the cellular mechanisms of inflammatory bowel disease.

Animals↗
PubMed1983

The Yersinia enterocolitica infection in acute abdominal surgery. A clinical study with a 5-year follow-up period.

By estimation of antibody titres or possibly isolation of the micro-organism, the role of the Yersinia enterocolitica as an etiological agent in mesenterial lymphadenitis, ileal inflammation, or abdominal colics was evaluated in 94 consecutive patients (25 operated upon and 69 treated conservatively) during a 1-year period from 1975-76. Eighty four patients (24 operated upon and 60 treated conservatively) were re-examined 5 years later. Among the 25 patients operated upon, three presented acute terminal ileitis, two of them in association with acute Y. enterocolitica infection. A substantial part of the 22 patients with other peroperative findings also presented trace or positive Y. enterocolitica antibody titres. Some of these patients experienced complaints attributable to the Y. enterocolitica infection over the following years. At re-examination, previously elevated Y. enterocolitica antibody titres had generally normalized, and in the two patients who in 1975 presented acute terminal ileitis associated with acute Y. enterocolitica infection, radiological examination now demonstrated normal terminal ileum. Among 69 patients treated conservatively for abdominal colics, 36 in 1975 presented trace or positive titres. During the 5-year follow-up period, abdominal pain and joint complaints were significantly more commonly experienced by patients with trace or positive titres than by patients with negative titres (p = 0.007 and p = 0.004, respectively). The Y. enterocolitica is an important cause of abdominal disease in our region, and the infection commonly gives symptoms of long duration.

Abdomen, Acute↗
PubMedDate not supplied

[Clinico-roentgenologic manifestations of intestinal lesions in pseudotuberculosis].

The authors presented the results of clinical and x-ray investigation of 102 patients with epidemic pseudotuberculosis (EP). The diagnosis was established on the basis of epidemiological evidence and the results of clinical and serological investigation. The affection of the digestive organs was observed not only in the abdominal type of EP but also in its other types. X-ray examination of the digestive organs revealed terminal ileitis in 56.8% of the patients alongside with functional disorders. X-ray examination plays a certain role in the differential diagnosis of EP from other diseases of the ileocecal region, in particular from acute appendicitis.

Adult↗
PubMed1999

Interaction between blood flow and motility in normal and inflamed ileum.

The alterations in local and superior mesenteric blood flow during ileal inflammation and their correlations with motility in the normal and the inflamed ileum were investigated in the conscious state. Ileal inflammation decreased the local mesenteric blood flow but had no significant effect on the superior mesenteric blood flow. A significant reduction or an increase in local mesenteric blood flow in the normal or the inflamed ileum had no effect on local contractile activity. The vascular reactivity to vaso-dilators and vaso-constrictors was significantly reduced during inflammation. Local mesenteric blood flow increased significantly in the descending segment ahead of a caudal propagating giant migrating contraction. The local mesenteric blood flow oscillated during a migrating motor complex (MMC) cycle. We conclude that a several-fold increase or decrease in local mesenteric blood flow lasting for several minutes does not affect contractility. Ileal inflammation decreases local mesenteric blood flow but does not affect the total blood flow to the small intestine.

Adrenergic alpha-Antagonists↗