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[Granuloma formation following intracutaneous administration of procaine-polyvinylpyrrolidone].

After intracutaneous application (dermojet) of procaine polyvinylpyrrolidone (PVP) because of backpain in a 60-year-old woman, multiple brownish-red nodules developed at the injection site within a few days. The histology showed signs of a sarcoid granuloma. There was no clinical evidence for sarcoidosis in this patient. An allergic reaction of the granulomatous type is suspected.

Back Pain↗

Airway and ventilator management.

The employment of a ventilator adds flexibility to the treatment of hypoventilation and hypoxia in the emergency department. Understanding the advantages of spontaneous respiration, the effects of positive pressure ventilation and the use of CMV, IMV, and PEEP allows for optimal care for emergency respiratory problems.

Anesthesia↗

[Evaluation of mass influenza prevention effectiveness using an inactivated chromatographic vaccine in Leningrad].

The work presents the evaluation of the effectiveness of mass immunization with inactivated chromatographic vaccine carried out in Leningrad during the influenza A (H3N2) epidemic of 1979--1980. These prophylactic measures were shown to cause a statistically significant decrease in morbidity rate among the vaccinees and the whole population (morbidity rate decreased 1.41 times among the whole population, 1.99 times among persons aged 8 years and over and 3.1 times among the vaccinees at industrial enterprises). The economic effect of 8.4 million roubles was achieved. To evaluate the apidemiological effectiveness of the above-mentioned antiepidemic measures, an original complex of techniques has been developed; such techniques can also be used for the evaluation of other similar measures.

Administration, Oral↗

[Comparative evaluation of the reactogenicity and antigenic activity of Soviet inactivated influenza vaccines].

The reactogenicity and antigenic potency of existing inactivated influenza vaccines were tested on 750 practically healthy adults. In all the preparations under test the levels of reactogenicity were found to correspond to the Technical Specifications TY--KBC, but the subunit type vaccine, "Gripovac", proved to possess the lowest reactogenicity and was, therefore, recommended for further trials in young children. Taking into account the characteristics of antigenic potency, the work gives grounds for the necessity of increasing the content of hemagglutinin in the vaccine prepared by the centrifugal method and for the practical use of the same volumetric dose (0.2 ml) for both virion vaccines (prepared by the centrifugal and chromatographic methods).

Adult↗

[Effectiveness of revaccinating hamadryas baboons with NISS live dried plague vaccine and fraction I of the plague microbe].

The effectiveness of some vaccine preparations for the revaccination of hamadryas baboons after their primary immunization with live plague vaccine " NIIS " administered in the form of aerosol was studied. The study was carried out under the conditions of the aerosol challenge of the animals with Y. pestis. The subcutaneous injection of plague vaccine " NIIS " was found to have advantages over its aerosol administration. Revaccination with Y. pestis fraction I, absorbed, was found to be 8 times more effective than the administration of plague vaccine " NIIS " by inhalation and not inferior to the subcutaneous injection of this vaccine. Y. pestis lipopolysaccharide, when injected simultaneously with fraction I, produced an immunosuppressive effect. The development of chemical plague vaccine on the basis of fraction I, intended for revaccination, was shown to have good prospects.

Aerosols↗

Anesthesia for CO2 laser surgery of the larynx.

The CO2 laser is a useful surgical tool in laryngology, but adds a significant anesthetic risk because of a constant fear of fire. This paper reviews the anesthetic problems of laryngology in general - competition for the airway between surgeon and anesthetist, circulatory changes associated with laryngoscopy, and postoperative laryngospasm and edema, as well as operating room pollution together with problems unique to laser usage. If endotracheal tubes are used, they may burn, the laser may be misaligned, endotracheal cuffs may burst, and there is a constant risk of a flash fire. The techniques favored are either a small born endotracheal tube wrapped in aluminum foil or an injection technique. The former may obstruct laryngeal lesions. The injection technique is described in detail together with the pharmacological management of anesthesia.

Air Pollutants, Occupational↗