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At least 685 records · Page 38Linked to original sources
PubMed2000

[Lichen striatus: evaluation of histologic criteria in 13 cases].

Lichen striatus (LS) is an uncommon dermatosis that generally affects children. Sometimes biopsy is required to assess the diagnosis. It is usually mentioned that LS has no specific histopathological criteria. Recently Gianotti et al., in 50% of the examined cases, found clues to the diagnosis. We have evaluated 13 biopsies of children affected by LS, in order to evaluate histopathological criteria to allow a diagnosis. The features nearly constantly present (12/13) in each specimen were focally band-like lymphocytic infiltrate with variable exocytosis and necrotic keratinocytes within the epidermis surrounded by lymphocytes. Epidermis hyperplasia, sometimes psoriasiform, was also present. In addition, one of remarkable the features of LS was the alignment of the infiltrate along eccrine ducts and glands and/or follicles. In 3 cases the deep lymphocytic infiltration was particularly dense. These results confirm that helpful clues to histopathological diagnosis of LS exist.

Biopsy↗
PubMed2000

[Cheyletiella dermatitis: an uncommon cause of vesiculobullous eruption].

BACKGROUND: Species of Cheyletiella mites are parasites hosted by dogs, cats and rabbits. In humans, they cause a dermatosis not well known by dermatologists. We report a case of an unusual, purely vesiculobullous eruption due to Cheyletiella blakei acquired from an infected cat. CASE REPORT: A 76-year-old woman presented a very pruritic eruption of vesicles and bullous lesions located on the trunk and external areas of the arms. Biopsy showed dermoepidermal cleavage and polynuclear infiltrate with prominent eosinophils, consistent with the diagnosis of bullous pemphigoid. We suspected a Cheyletiella dermatitis due to the aspect and distribution of the elementary lesions and the fact that prior to the eruption the patient had acquired a cat that sometimes slept in her bed. The diagnosis was confirmed by a veterinary examination and isolation of Cheyletiella blakei from the cat's skin. The cat was treated successfully with ivermectin, while the household was disinfected with permethrin. A treatment with benzyl benzoate (Ascabiol) resolved all the patient's symptoms. DISCUSSION: This case is particularly interesting due to the purely vesiculobullous pattern of the rash and by the difficulty and considerable delay of diagnosis. Patients who have recently acquired a cat or dog before developing a pruritic dermatosis may indeed have cheyletiellosis.

Aged↗
PubMed2000

[Epidermoid cyst of the testis. Conservative surgery in 3 cases].

The authors report 3 cases of epidermoid cyst of the testis. Clinical, laboratory and ultrasound data were relatively nonspecific. Precise histological criteria were defined by PRICE in 1969. The diagnosis is based on frozen section examination after transnnguinal testicular exploration. The authors describe the most conservative therapeutic approach for a constantly benign testicular tumour.

Adult↗
PubMed2000

[Nomenclature problems in glaucoma].

UNLABELLED: To present suggestions concerning the nomenclature of different types of primary glaucoma. METHODS AND RESULTS: The new nomenclature of primary glaucoma was proposed basing on the pathogenesis of the disease and semantic functions of different definitions.

Glaucoma↗
PubMedDate not supplied

[Accidental ingestion of paracetamol in the for of the pediatric syrup EFFERALGAN: case studies during the six months following the institution of the child-proof top].

During the 6 months following the child-proof top commercialisation for the paediatric syrup EFFERALGAN in France, 51 cases of accidental ingestion were collected by the Marseilles Poison Centre. For 21 pour cent of them, the alleged dose taken was greater than the toxic dose. For 2 cases only, the responsible bottle had a child-proof top and was open on the table. For all other cases, it was simple-opening bottles (old bottles still present in houses, or bottles without a special top but sold in order to get rid of stocks). This study proves that such a preventive measure (modification of the top of the syrup bottles) is only fully effective if additional measures are undertaken such as return of unsold stocks or the provision of information to pharmacists and physicians.

Accidents↗
PubMed2000

[Use of cyclophotocoagulation with diode laser in treatment of secondary glaucoma in children].

AIM OF THE PAPER: To evaluate the effectiveness of transscleral diode laser cyclophotocoagulation in treatment of secondary glaucoma in children. MATERIAL AND METHODS: 50 children (50 eyes) with secondary glaucoma (aphakic, posttraumatic, in Sturge-Weber syndrome and in aniridia) which was uncontrolled with medical and surgical therapy or the surgery had a high risk of postoperative complications. In all patients diode laser transscleral cyclophotocoagulation has been performed. RESULTS: After one month intraocular pressure was reduced (with or without medical treatment) below 23 mm Hg in 40% of patients and after 6 months in 68% of patients. The worst results were observed in posttraumatic glaucoma. CONCLUSION: Diode laser transscleral cyclophotocoagulation is a safe and effective method of secondary glaucoma therapy in children uncontrolled with other methods of medical and surgical therapy or when the surgery has a high risk of postoperative complications.

Adolescent↗
PubMed2000

[Treating retinopathy of prematurity with laser diode photocoagulation].

AIM: The purpose of the study was to assess the outcomes of the diode laser in the treatment of retinopathy of prematurity and to discuss the up-to-date possibilities of treating of active phase of this disease. MATERIAL AND METHODS: 96 children (185 eyes) treated with diode laser retinal photocoagulation for active stage 3 of ROP in our department in years 1996-2000. RESULTS: Favorable structural outcome was observed in 83.8% of treated eyes. In the remaining eyes the disease progressed despite of the treatment and falciform retinal fold (5.4%), partial retinal detachment (6.5%) and total retinal detachment (4.3%) developed. No serious complications were observed after the treatment. CONCLUSIONS: Diode laser retinal photocoagulation is a safe and effective procedure for treating active stage 3 of retinopathy of prematurity. It has been especially useful for treatment of changes in zone 1 and 2 of the disease. Diode laser photocoagulation is now the preferred method of treating active stage 3 of ROP in our department.

Adolescent↗
PubMed2001

[Correlation between Gleason score of prostatic biopsies and the one of the radical prostatectomy specimen].

UNLABELLED: The Gleason score obtained on prostatic biopsies is an essential element in the treatment decision for localized prostate cancer. The objective of this study was to evaluate the correlation between the biopsy Gleason score and the definitive Gleason score and to propose a classification into 3 groups in order to improve this correlation. MATERIAL AND METHODS: One hundred radical prostatectomies were performed between 1995 and 1998. Eighty four of these patients underwent 6 biopsies. The Gleason score of the biopsies and operative specimens were compared. The concordance between the biopsy Gleason score and the operative specimen Gleason score was initially analysed score by score. The concordance was then established according to three groups, well differentiated tumours (score 2-4), moderately differentiated tumours (score 5-7), poorly differentiated tumours (score 8-10). RESULTS: The concordance between the biopsy Gleason score and the operative specimen Gleason score was perfect in only 37% of cases. A 1-point difference of the score was observed in 35.7% of cases and a 2-point or greater difference was observed in 27.3% of cases. By classifying patients into 3 groups, the concordance increased from 37% to 72.6%. CONCLUSION: The classification of patients into three distinct groups (well, moderately and poorly differentiated tumours) increases the concordance between the biopsy Gleason score and the definitive Gleason score. However, the limitations of the biopsy Gleason score must be kept in mind, particularly in the case of low-grade tumours.

Biopsy, Needle↗
PubMed2001

Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes.

The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipoprotein cholesterol contents were also examined. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, macrosomic pups had higher serum, LDL-HDL(1), and HDL(2-3) cholesterol levels (P < 0.05) associated with increased LCAT activity (+57%) compared with control values. At 1 and 2 months of life, serum and lipoprotein cholesterol concentrations in macrosomic rats were similar to those of controls, whereas LCAT activity remained elevated about 1.5-fold. In addition, there was no change in hepatic cholesterol contents but hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and ACAT activities were higher in both macrosomic males and females than in their respective controls (P < 0.01). By 3 months, macrosomic rats had developed hypercholesterolemia with a rise in all lipoproteins. Enzyme activities were still increased in these mature macrosomic rats, and hepatic cholesteryl esters were higher only in macrosomic females. These data demonstrate an overproduction, combined with overutilization, of cholesterol during the phase of rapid growth in macrosomic rats. However, cholesterol oversynthesis exceeded its removal and was a major contributor to hypercholesterolemia in adult macrosomic rats. In conclusion, macrosomia was associated with alterations in cholesterol metabolism through adulthood.

Acetyl-CoA C-Acyltransferase↗
PubMedDate not supplied

[Oxidative stress and human disease. Current knowledge and perspectives for prevention].

DYNAMIC BALANCE: The antibiotic status of the human organism results from the dynamic balance between the antioxidant system and the production of reactive oxygen species. Oxidative stress occurs when this balance shifts in favor of pro-oxidants as can occur in several disease situations. ROS: Part of the oxygen used by cells is transformed into toxic metabolites, reactive oxygen species (ROS), which can be the cause or consequence of tissue and molecular disorders. Some of the most prominent diseases linked with oxidative stress include atherosclerosis, cancer, allergy, neurodegenerative diseases, Parkinson's disease. PERSPECTIVES FOR PREVENTION: Actions designed to prevent the environmental cause, such as eviction of a exposure to toxins or a change in eating habits, can be an effective means of reducing the lesions induced. Study of total antioxidant potential could be quite useful for detecting and monitoring environmental damage and for clinical follow-up. It could also help in determining, for each individual, the negative or positive development of a therapy on the anti-free radical action. Treatments must be personalized according to the tested response.

Arteriosclerosis↗
PubMed2001

[Melorheostosis associated with arteriovenous malformation of the ear].

BACKGROUND: Melorheostosis is a rare bone dystrophy that may be associated with various vascular malformations. We report a case of arteriovenous fistulae of the ear associated with melorheostosis limited to the same side of the body. CASE REPORT: A 13 year-old boy presented a congenital port-wine nevus of the right side of the head complicated by an arteriovenous fistulae and angiomatous nodules of the ear. He was treated by laser, surgery of the nodules, arterial embolisations and sclerotherapy. In 1999, he had a benign trauma of the right hand. The X-ray showed hyperostosis resembling wax flowing down a candle reaching the carpus and some of the metacarpals and the phalanges of the right hand, typical of melorheostosis. The complete radiographic check-up showed the same characteristic appearance on the right side of the skull and the long bones of the right upper limb. Except a deformation of the right fingers, there were no others symptoms. DISCUSSION: Melorheostosis is a rare, sporadic and benign bone dysplasia that may be localized to a single limb or disseminated. The diagnosis is usually made in late childhood. Pain, stiffness, deformation of a limb are the main clinical manifestations. The skin may be erythematous and sclerotic. The radiographic appearance is characteristic with hyperostosis on one side of the bone resembling wax flowing down a candle. A vascular abnormality is present in 17 p. 100 of cases (hemangiomas, aneurysms, renal artery stenosis.). In these cases, melorheostosis is usually limited to the same side of the vascular lesion. We report the first case of arteriovenous fistulae of the ear associated with melorheostosis, on the same side of the body. The physiopathology of melorheostosis is still unknown but the association with a homolateral vascular abnormality suggests a localized defect in embryogenesis of the vascular and skeletal systems.

Arteriovenous Fistula↗
PubMed1995

[The reproduction of the population in the seventeenth, eighteenth, and nineteenth centuries. Examples from France and Quebec].

This article examines the descendants of four cohorts of couples formed in the seventeenth and eighteenth centuries (two cohorts in two French mountain valleys and one on the Ile-d'Orléans in Quebec). The children are separated into four categories according to their fate (deceased while still unmarried, unknown fate, married but childless, "useful children"). "Useful children", a concept used in population genetics, are those who in turn bear children. In all three places, the useful children represent only from 26 to 31% of births. The study goes on to measure the contributions made by these couples to the next generation. In the mean, each couple gave birth to little over one useful child. But the contributions of couples turns out to be very unequal. Depending on the place, from 36 to 53% of couples left no useful children behind them, while a small minority of couples made an ample contribution to the next generation. The same measure is reproduced in the constitution of the next generation, thereby showing that inequality of couples in terms of reproduction is perpetuated.

Canada↗