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[Structuring and use in clinical research of a software for the diagnosis and features of polypoid lesions of the colorectum].

Double contrast enema and endoscopy are very important in the diagnosis of adenomas and early cancer of the colon and rectum. These exams can not only detect the presence, but also suggest the histologic diagnosis, of polypoid lesions of the colon. An Olivetti M24 Personal Computer was used to create a software to study the results obtained by double contrast enema, and to compare them with endoscopy and pathology. The data base is formed by 7 files: one anagraphic, 3 collecting the characteristics of the diagnosis--namely the radiologic, the endoscopic and the pathologic one-- and 3 multiple files featuring each lesion, as defined by the three diagnostic techniques. The software allows to evaluate the different lesions that can be detected by the three techniques in the same patient and to compare the diagnosis of presence to the morphologic features of each lesion. False negatives and false positives of each technique are easily recognized. It is also possible to characterize the single morphologic feature leading the radiologist and/or the endoscopist to express an opinion about the histologic diagnosis of each lesion and to compare them with pathological features. The first experience in clinical use of the software, in the analysis of the characters of 336 lesions in 218 patients, is described.

Colonic Neoplasms↗

Microcomputer software and interface for control of a microscope scanning stage.

Motorized scanning stages are valuable in microscopy systems that employ digital image analysis and for the development of semiautomatic computer-assisted microscope systems; the development of standard software "tools" to control such stages will facilitate their integration into a variety of computer-based systems. A set of Microsoft BASIC and Turbo PASCAL programs that interfaces a microprocessor-controlled stepper motor microscope stage (MDACE 1000) to an IBM PC or PC-AT or compatible microcomputer via a serial interface (RS-232) is described. These programs can be integrated into other software written in either BASIC or PASCAL, or used via a menu program that directs the routines to control scanning patterns and to locate the microscope stage to a selected area of the slide. Coordinates of significant events on a slide can be stored on a disk file to allow future examination. The software and interface also provide control of a filter wheel in the microscope for use in multicolor fluorescence assays.

Computers↗

Computerized accounting for the dental office. Using horizontal applications general ledger software.

Remember that computer software is designed for accrual accounting, whereas your business operates and reports income on a cash basis. The rules of tax law stipulate that professional practices may use the cash method of accounting, but if accrual accounting is ever used to report taxable income the government may not permit a switch back to cash accounting. Therefore, always consider the computer as a bookkeeper, not a substitute for a qualified accountant. (Your accountant will have readily accessible payroll and general ledger data available for analysis and tax reports, thanks to the magic of computer processing.) Accounts Payable reports are interfaced with the general ledger and are of interest for transaction detail, open invoice and cash flow analysis, and for a record of payments by vendor. Payroll reports, including check register and withholding detail are provided and interfaced with the general ledger. The use of accounting software expands the use of in-office computers to areas beyond professional billing and insurance form generation. It simplifies payroll recordkeeping; maintains payables details; integrates payables, receivables, and payroll with general ledger files; provides instantaneous information on all aspects of the business office; and creates a continuous "audit-trail" following the entering of data. The availability of packaged accounting software allows the professional business office an array of choices. The person(s) responsible for bookkeeping and accounting should choose carefully, ensuring that any system is easy to use, has been thoroughly tested, and provides at least as much control over office records as has been outlined in this article.

Accounting↗

Software design for an inexpensive, practical, microcomputer-based DNA cytometry system.

Recent advances in digital electronics have made it possible to put together videophotometry systems capable of practical DNA ploidy measurements at a relatively modest cost. Such a system, based upon the IBM PC microcomputer and other "off-the-shelf" components, is now operational in our laboratory. This paper discusses the design considerations that went into the development of the software for this system. It examines the choices, constraints and tradeoffs involved in such a software engineering project and considers the practical implementation of image processing algorithms and a user-friendly interface. An overview is given of the modular, menu-driven software through which the system is controlled, along with a description of normal operational flow.

Cell Nucleus↗

Faculty authoring of course-specific software for disadvantaged nursing students using LinkWay: a case study.

This article adds to the literature on the use of hypermedia systems for software development in nursing education by describing design and authoring considerations in the construction of course-specific remediating software. In 1991, under the guidance of an instructional designer, faculty members developed LinkWay folders on aspects of the endocrine system for remedial use by students in Project Get Ahead in Nursing at Southern Illinois University at Edwardsville. Existing content outlines were modified according to design criteria, including representing information graphically, making the software translation interactive, embedding visual prompts and cues, and conforming to a specific design protocol. The use of LinkWay in facilitating the implementation of both procedural of both procedural and screen protocol is discussed, and several screen templates are presented, including menus, multiple choice, short answer, multiple choice browsing, and end-of-section evaluation. Current project status and conclusions for remediation using a hypermedia approach are discussed.

Computer-Assisted Instruction↗

[A user evaluation of software programs in family practice].

Software for electronic patient journals was evaluated. A questionnaire was sent to a total of 551 general practitioners working on contract, salaried general practitioners and specialist practitioners. Among the 345 respondents, 63% used electronic journals. Three programs dominated. Legeservice (n = 94) was exclusively used by salaried general practitioners, Profdoc (n = 88) and Infodoc (n = 34) were preferred by general practitioners working on contract and by specialists. In the latter group only 40% used electronic journals. In general, the users of Profdoc and Infodoc were satisfied with the central functions of the software and the service provided by the suppliers. The users of Legeservice were significantly less satisfied. In conclusion, some of the existing software for patient journals in Norway can safely be recommended.

Evaluation Studies as Topic↗

Building Internet accessible medical education software using the World Wide Web.

We describe work to enhance existing software protocols and develop a suite of new software utilities based upon a set of standards known as the World Wide Web (WWW). Specifically, we have developed an effective X-windows based WYSIWYG WWW browser/editor and a prototype for integrated wide-area authentication and authorization support for delivery and maintenance of WWW service. These software development activities, along with parallel work in content development, are empowering individuals to better use the Internet as a resource to easily author, publish, and access materials. As an illustrative application, we describe one Web-based self-instructional unit designed to increase users' knowledge of hazardous substances in the environment. This on-line monograph was adapted from a series of paper-based case studies developed by the Agency for Toxic Substances and Disease Registry of the U.S. Department of Health & Human Services. The on-line version illustrates many of the innovative features provided by the Web, and demonstrates how such materials can significantly impact medical education at all levels.

Computer Communication Networks↗

Database and software for the analysis of mutations in the human p53 gene.

Mutations of the human p53 gene are of importance in the development of cancer. Perhaps 50% of all human cancers contain a mutation in the p53 oncogene and many laboratories are investigating mutations at this locus. In an effort to centralize and standardize the information regarding human p53 mutations, we have created a computerized database that contains information about DNA sequence alterations for > 3000 p53 mutants. Information on the cancer type, the origin of the cells, the specific mutation, the amino acid change, the literature citation, and other data are provided for each mutant. We have also produced a software package for the analysis of the p53 database. Routines have been developed for the analysis of single-base substitutions, including programs to (a) determine whether two mutational spectra are different, (b) display the number of mutations and mutable sites in each exon, (c) determine whether mutations show a DNA strand bias, (d) determine the frequency of transitions and transversions, (e) display the number and kind of mutations observed at each base in the coding region, (f) perform nearest neighbor analysis, and (g) display mutable amino acids in the p53 protein. The software runs only on IBM-compatible machines with MS-DOS. The software and p53 database are freely available via the Internet, using the remote file transfer protocol. These programs simplify the analysis of the rapidly increasing body of information about p53 mutations. The programs permit facile comparison between different p53 data sets, as well as the identification of mutational patterns that may be of importance to experimenters studying the mechanisms of mutation and the etiology of cancers.

Base Sequence↗

[CASTOR-Radiology: software of management in a Unit of Medical Imaging: use in the CHU of Tours].

Despite the large volume of information circulating in radiology departments, very few of them are currently computerised, although computer processing is developing rapidly in hospitals, encouraged by the installation of PMSI. This article illustrates the example of an imaging department management software: CASTOR-Radiologie, Computerisation of part of the Hospital Information System (HIS) must allow an improvement in the efficacy of the service rendered, must reliably reflect the department's activity and must be able to monitor the running costs. CASTOR-Radiologie was developed in conformity with standard national specifications defined by the Public Hospitals Department of the French Ministry of Health. The functions of this software are: unique patient identification, HIS base, management of examination requests, allowing a rapid reply to clinician's requests, "real-time" follow-up of patients in the department, saving time for secretaries and technicians, medical files and file analysis, allowing analysis of diagnostic strategies and quality control, edition of analytical tables of the department's activity compatible with the PMSI procedures catalogue, allowing optimisation of the use of limited resources, aid to the management of human, equipment and consumable resources. Links with other hospital computers raise organisational rather than technical problems, but have been planned for in the CASTOR-Radiologie software. This new tool was very well accepted by the personnel.

France↗

Non-invasive assessment of cardiovascular mechanics using a new, user-friendly software application.

Currently, in most non-invasive imaging laboratories, echocardiographic tracings are interpreted by "eyeballing" M-mode and 2-dimensional echocardiographic recordings. This subjective method of data analysis severely hampers the possibility of serial assessment of physiological interventions on cardiovascular disease states. Moreover, acquisition of important cardiovascular physiological data usually requires recordings of instantaneous aortic pressure and flow data that, until recently, could only be acquired invasively in the cardiac catheterization laboratory. Recently, our laboratory has developed and validated new "non-invasive" methods for the acquisition of aortic pressure and flow using calibrated subclavian pulse tracings and continuous wave aortic Doppler, respectively. With these limitations and new developments in mind, we developed new software that enables simultaneous non-invasive acquisition of left ventricular (LV) chamber geometry and aortic pressure and flow data. This new, user-friendly software in conjunction with other non-invasive tools allows non-invasive quantification of multiple cardiovascular physiological parameters. More importantly, the new software enables objective and serial assessment of multiple pharmacological interventions on various patients' disease states.

Aged↗

Occupational health software: selecting the right program.

1. Occupational health nurses who are selecting software should identify specific goals for computerization, such as tracking compliance activities or analyzing trends. 2. Nurses should evaluate software programs by the extent to which each achieves these goals without exceeding available resources. 3. Successful software installations require commitment from an on site project manager to ensure that the program meets specifications and that the vendor provides adequate user training and ongoing support.

Humans↗

Guidelines for the evaluation of instructional software by hospital nursing departments.

Hospital nursing departments are becoming more receptive to the use of computer assisted instruction to facilitate and augment educational requisites for both staff and client. Numerous guidelines exist for software assessment, but none has been devised specifically for the often inexperienced hospital nursing committee charged with software review. This paper introduces the Hospital Oriented Instructional Software Evaluation, guidelines developed specifically for hospital use.

Computer-Assisted Instruction↗

SURVIVAL--an integrated software package for survival curve estimation and statistical comparison of survival rates of two groups of patients or experimental animals.

SURVIVAL, a new integrated software package for survival curve estimation and statistical comparison of survival rates of two censored or uncensored groups of patients or experimental animals, is described and demonstrated. The software is based on the calculation of the Kaplan-Meier estimates of survival curves and utilizes the Mantel-Haenszel and/or Fisher's test for the statistical comparison of the corresponding survival rates. SURVIVAL can be used for statistical evaluation of survival data obtained either on sequentially created or fixed size groups. The software is menu driven to provide a very user friendly tool for analyzing survival data. It may be of great value mainly in clinical use because it automatically enables evaluation of a large set of survival data, sequentially collected in SURVIVAL's own database during a long survival study, with entry and evaluation possible at any time during the study.

Animals↗

The use of ADAM software in podiatry.

ADAM (Animated Dissection of Anatomy for Medicine) software is a versatile, multimedia computer program designed to enhance doctor-patient communication. This interactive software promises to play a major role in health care in the 21st century. Podiatric applications of this software are discussed in this article.

Foot↗

[Computerized three-dimensional reconstruction of human embryos and their organs using the "NIH image" software].

Three-dimensional structures of human embryos and their internal organs were reconstructed on a CRT from their serial histological sections using a free computer software system "NIH Image." It was possible to rotate the computer images on CRT and to make cut models on any desired plane. In addition, various developmental changes could be animated by artificial "morphing" between the models at different stages. Computer graphic modeling should be of great value in the study of normal and abnormal morphogenesis. The "NIH Image" software is freely available via computer networks and has a lot of advantages over previously developed software programs used for three-dimensional reconstruction.

Computer Graphics↗

[POLAIR: software and methodological guide for the epidemiological investigation of a point source atmospheric pollution].

The POLAIR software is designed to guide the user along a methodological approach to assess the health consequences of an accidental or chronic point source atmospheric pollution. This article presents the two components of the software, i.e. the gaussian modelization of the pollution contour lines on the territory around the emission source that allows to calculate an exposure index for every individual with a space-time ponderation factor, and the implementation, by using the EPI-INFO software, of a case-control or historical cohort epidemiological study among the population living in the vicinity of the source. Standardized questionnaires for the collection of data in the field are proposed, and the steps of the data analysis are commented upon, on the basis of an illustrative example.

Air Pollution↗

Determination of sleep and wakefulness with the actigraph data analysis software (ADAS).

Current evidence has shown that, overall, actigraphy is an excellent tool for unobtrusive documentation of sleep/wake activity in normal individuals. However, a number of methodological issues remain to be resolved to warrant its use in clinical research. In this paper, we report the results of a study aimed at the development of a new scoring software that can accurately identify sleep and wakefulness. Using total sleep time as an index of comparison, the software was optimized on a calibration sample and prospectively tested on a validation sample. A strong correlation coefficient (r = 0.93, p < 0.008), with an average discrepancy value of 10 minutes, was observed for the calibration sample. The application of the optimal software to the validation sample revealed an even higher correlation coefficient (r = 0.97, p < 0.0001), with an average discrepancy value of 12 minutes.

Adult↗

[Selection criteria for dental software].

Dentists who wish to introduce a computer based patient record system in their office are confronted with a lack of information concerning the selection of dental software. As wishes and demands concerning the content and options given by a dental computer program can vary widely from dentist to dentist and as dental software is changing rapidly a global objective evaluation is of no practical validity. Therefore a list of general and specific selection criteria was developed, enabling the practitioner to make a personal, objective comparison of quality of content versus wishes, price and service of different dental software programs. The criteria are discussed in this article.

Computer Peripherals↗