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Strabismus in childhood.

We have discussed what constitutes a normal visual and ocular system in children and the inherent mechanisms that help each person develop and maintain normal visual function. This ideal status should include good visual acuity in each eye, straight eyes, and the development of fusion. Strabismus represents an obstacle to obtaining these goals and may be caused by poor vision, refractive errors, or anatomic, structural, or innervational abnormalities. Each of these conditions is treatable and correctable when discovered early. With early identification, proper treatment can be instituted and the patient can have the opportunity to develop optimal vision with fusion and depth perception -- a lifetime benefit. Several other types of strabismus respond poorly to the use of glasses, prisms, exercises, or medications and can be effectively treated only by surgical methods. Most divergent and vertical deviations fall into this group, as do ocular deviations associated with paretic or structurally abnormal muscles.

Amblyopia↗

Strabismus.

Patients with strabismus should be viewed as having a serious ocular disorder requiring early diagnosis and evaluation. They should also be encouraged to have proper therapy so that they may be returned to a more normal ocular status at the earliest possible age. The ultimate goal of the pediatric ophthalmologist is always good vision and proper alignment. Neither alone is acceptable. The pediatric practitioner should diagnose strabismus disorders at the earliest possible age so that full and proper treatment may be brought to bear, thus allowing the patient to enjoy binocular vision function throughout life.

Aging↗

Ketamine anesthesia in strabismus surgery.

Because of the conflicting opinions in the ophthalmic literature concerning the efficacy of Ketamine anesthesia in strabismus surgery, we decided to report out experience in 44 children operated upon between the ages of six months and six years. Satisfactory anesthesia was achieved in all cases except two who required intubation and inhalation technique in order to complete the surgery. No serious side effects were observed during or after the surgery. Its ease of administration, freedom from side effects, and satisfactory anesthesia, make Ketamine our primary anesthetic choice for strabismus surgery in children.

Anesthetics↗

Previous strabismus surgery and eye position under anesthesia.

We studied eye position under general anesthesia in 51 patients with concomitant esotropia or exotropia, divided into two groups. One group consisted of strabismus patients who had had no previous surgery. The second group consisted of strabismus patients who had undergone previous surgery on one (asymmetric) or both (symmetric) eyes. We found that both groups showed either no change or more divergence under general anesthesia in comparison to their preoperative state. Those patients who had had no previous surgery revealed an equal divergence in both eyes. This relationship also held true for those patients who had undergone symmetrical surgery in both eyes. However, those patients who had had surgery in one eye only showed more divergence in the operated eye than in the unoperated one. These findings reflect the mechanical--anatomical factors created by the surgery itself.

Adolescent↗

Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery.

Fifty-six injections of botulinum A toxin have been given to humans for correction of strabismus. The paralysis has been localized to the injected muscle in all cases. No systemic complications of any kind have ensued. The maximum time of paralysis occurs four to five days following the injection, and then gradually diminishes, depending on dose. The maximum correction of strabismus has been 40 prism diopters. The maximum follow-up after injection is six months. Injection of botulinum A toxin into extraocular muscle to weaken the muscle appears to be a practical adjunct or alternative to surgical correction.

Adult↗

See-saw nystagmus after strabismus surgery.

A 7-year-old child underwent craniotomy for a craniopharyngioma. One month later she developed a divergence excess type exotropia and had strabismus surgery 11 months later. The day after strabismus surgery, the parents noted abnormal eye movements that represented see-saw nystagmus. The patient had a small esotropia after surgery, but it was found that stimulated convergence controlled the nystagmus. This case illustrates the dual central and ocular influence on the development of see-saw nystagmus.

Child↗

The role of retinal cryopexy in the management of experimental perforation of the eye during strabismus surgery.

In order to investigate the role of retinal cryopexy in the management of accidental perforation of the globe during strabismus surgery, the retinas of 30 rabbit eyes were perforated with a needle simulating the clinical incident. Ten of these eyes received no further treatment, ten eyes were treated with moderate transscleral cryopexy of the surrounding retina, and the remaining ten eyes were treated with excessively heavy cryocoagulation. The incidence of secondary retinal detachment was identical in the first two groups of rabbits, while it was markedly increased in those rabbits treated with excessively heavy transscleral cryopexy (P less than .01). Based on these findings and a review of the literature, recommendations are made for the management of accidental perforation of the globe during strabismus surgery.

Animals↗

A comparison of the succinylcholine induced ocular position and the postoperative alignment in strabismus.

Succinylcholine was injected intraoperatively in 41 strabismus patients with congenital esotropia or intermittent or constant exotropia. Regression analyses were performed to investigate the predictive relationships between the one-, six-, and 26-week postoperative alignment and the intraoperative, succinylcholine-induced ocular position. Ocular position, determined by the interlimbal distance in millimeters, was calculated using a semi-automated, video replay analysis system. Large, statistically significant correlation coefficients were obtained for patients undergoing bimedial recessions of 4.0 to 5.5 mm and bilateral lateral rectus recessions of 5.0 to 7.0 mm. Small correlations were obtained for esotropes undergoing the recession/resection procedure and those with bimedial recessions of 6.0 mm or greater. These data support the theory that the succinylcholine-sensitive subgroup of the extraocular muscle fibers are those whose tonic contracture provide the motor component to ocular alignment. Sample sizes at present are insufficient to suggest clinical use of these data. In future research, these relationships will be tested for their ability to predict postoperative alignment and thereby, improve success rates in strabismus surgery.

Adolescent↗

Artifacts of measuring during strabismus surgery.

Several different artifacts can induce errors in measurements obtained during strabismus surgery. Fixating the severed rectus muscle stump with forceps during strabismus surgery can result in a temporary anterior displacement of the insertion. This may result in inaccuracies in determining the site to which the muscle is to be recessed. This displacement was quantified in a prospective masked manner and was found in some patients to result in as much as 1 mm of error. It can be prevented by measuring the recession prior to fixating the insertion stump with forceps; however, it cannot always be prevented by measuring from the limbus, which also introduces other artifacts due to geometric principles. An "advancement effect" occurs during a rectus muscle recession due to the mechanics of suture placement in the muscle. It was quantified in a masked manner and found to be approximately .5 mm in most cases. A "V" shaped deformity of the insertion stump may occur immediately adjacent to the forceps. This deformity frequently distorts the insertion by as much as several millimeters.

Humans↗

Adjustable suture strabismus surgery for acquired vertical deviations.

Forty-seven patients undergoing 51 adjustable suture strabismus procedures for acquired vertical deviations were evaluated for preoperative and adjustment factors which might influence the postoperative alignment. The type of deviation, surgical procedure, previous surgery, immediate postadjustment alignment, and immediate postadjustment versions were assessed. Oblique muscle surgery in addition to an adjustable vertical rectus muscle significantly decreased the success rate (p = .0303). Other less important factors were a previous history of strabismus surgery and a moderate limitation of versions following the adjustment. A slight over- or undercorrection after adjustment did not affect the success.

Adolescent↗

An investigation of the clinical use of botulinum toxin A as a postoperative adjustment procedure in the therapy of strabismus.

Attempts to circumvent multiple surgical procedures are an integral part of the history of investigations in strabismus. In 1973, Botulinum toxin A (Oculinum) injections into human EOM was proposed as an alternate method to surgery for strabismus and has since proved to be effective. This article reports the results from a retrospective investigation of EOM Oculinum injection used in the postoperative period as an alternate to additional surgery. It is difficult to establish whether Oculinum altered the time span of the clinical course in these patients, but when it was effective, it provided unprecedented convenience.

Adolescent↗

Recovery of extraocular muscle function after adjustable suture strabismus surgery under local anesthesia.

Limited data exist on the recovery of ocular motility after adjustable suture strabismus surgery performed under local anesthesia. The timing of adjustment has been chosen empirically and has varied widely. We sought to more precisely quantify the recovery of motility by measuring ductions before and after surgery with a modified arc perimeter. Twenty-one eyes of 20 patients were studied. All patients underwent adjustable suture strabismus surgery under retrobulbar or peribulbar anesthesia using 2% lidocaine with hyaluronidase. Mean ductions orthogonal to the field of action of the operated muscle(s) returned to 90% of preoperative levels between 5 and 6 hours after injection. We recommend adjustment 6 or more hours after injection, or at least 5 to 6 hours postoperatively, when 2% lidocaine with hyaluronidase is used for local anesthesia.

Adult↗

Preservation of anterior ciliary vessels during strabismus surgery: a nonmicroscopic technique.

Preservation of anterior ciliary vessels (ACVs) during strabismus surgery using microscopic dissection techniques and the operating microscope has been previously described. We describe a technique using standard loupe magnification for vessel preservation, in 77 patients, ages 7 months to 69 years, who had surgery between January 1989 and September 1990. ACVs, with a small sheath of connective tissue, were dissected off the surface of the muscles and tendons using blunt and sharp dissection with Knapp iris hooks and Vannas scissors. Key elements of the dissection were sufficient separation of the vessel complex from the anterior tendon insertion and the use of blunt rather than sharp dissection. We successfully preserved 125 ACVs in 97 muscles. Ninety-five vessels were saved with 71 recessions, 14 with 13 resections, and 16 with adjustable sutures. The success rate of surgery was 85% in surgeries done either with or without anterior ciliary preservation. Vessel dissection time averaged 5 to 10 minutes per muscle. ACV preservation can be easily and successfully performed in routine strabismus cases. The procedure does not require the operating microscope and can be done under standard loupe (1.5 to 3.0 x) magnification. This procedure theoretically reduces the risk of anterior segment ischemia in situations where the patient is thought to be at significant risk for this complication.

Adolescent↗

Refractive error changes following strabismus surgery.

Several uncontrolled, retrospective studies have suggested that permanent changes in refractive error can be seen following strabismus surgery. We prospectively enrolled 68 patients undergoing strabismus surgery for evaluation of pre- and postoperative cycloplegic refraction. In addition, the adult patients had computerized corneal topography recorded using the Corneal Modeling System, (Computed Anatomy, Inc, New York, NY). Pre- and postoperative refractions were compared using spherical equivalent and meridional equivalent (90- and 180-degree meridian). We found no significant change in the spherical equivalent between the pre- and postoperative measurements. However, a significant increase in the astigmatic power at 180 degrees (meridional equivalent at 180 degrees) was detected in both pediatric and adult patients. We did not observe any qualitative change in the corneal topography pre- and postoperatively. The change in astigmatic power at 180 degrees is equivalent to additional plus-cylinder correction at 90 degrees and was persistent throughout the 4-month postoperative period.

Adolescent↗

A comparison of the success rates of resident and attending strabismus surgery.

Residency training involves surgery by resident surgeons at various levels of experience and proficiency, supervised by an experienced attending physician. We reviewed the results of strabismus surgery performed at four institutions with two residency training programs. Five hundred twenty-two cases with follow up greater than 6 weeks were evaluated. These cases included 315 attending procedures and 207 resident procedures under direct attending supervision. Success was defined as a strabismic deviation of 8 prism diopters or less. Average postoperative follow-up was 57 weeks and did not differ between groups. There was no statistical difference between the resident success rate of 58% (121/207) and the attending success rate of 69% (217/315) after adjusting for population differences. The average final deviation of the patients postoperatively was 7 delta for the attending group and 10 delta for the resident group. Amblyopia was significantly more frequent in the resident cases (P < .001). Adjustable sutures were used significantly more often in attending cases (P < .0001). This study supports the premise that resident strabismus surgery is as successful as attending surgery.

Adolescent↗

Quantitative magnetic resonance morphometry of extraocular muscles: a new diagnostic tool in paralytic strabismus.

Paralytic strabismus is often diagnostically ambiguous due to the similarity of patterns of misalignment produced by different mechanisms. To address this problem, we have developed a new technique employing high-resolution, surface coil magnetic resonance imaging to quantify extraocular muscle size and contractility. Adjacent coronal images are obtained spanning the anteroposterior extent of each orbit, and repeated in multiple directions of gaze. Contractility is evaluated from analysis of muscle cross-sectional areas. The quantitative size and contractile characteristics of normal rectus and superior oblique muscles are reviewed, along with the effects of superior oblique palsy. The morphometric features of lateral rectus palsy are illustrated by three clinical cases exhibiting deficient contractility and atrophy of the lateral rectus muscle. A case of superior oblique palsy is presented illustrating atrophy and lack of contractility of the involved superior oblique muscle. This imaging technique can be employed in any clinical center and permits insight into extraocular muscle function in complex strabismus cases.

Adult↗

Management of experimental globe perforation during strabismus surgery.

BACKGROUND: The incidence of potentially vision-threatening globe perforation during strabismus surgery is reportedly between less than 1% and 12% of cases. Optimal treatment of globe perforation is not known; however, traditionally it has been treated with cryotherapy at the time of surgery or observation without treatment. The indirect-ophthalmoscope-directed diode laser may provide a safe and effective alternative treatment. METHODS: We perforated the globes of six adult Dutch rabbits (12 eyes) and treated four eyes with cryotherapy and four with diode laser; the remaining four were not treated. RESULTS: Histologic examination of the untreated eyes revealed a cellular reaction around the polyglactin suture that formed a non-uniform chorioretinal adhesion. The cryotherapy eyes had a tenuous chorioretinal adhesion and retinal pigment epithelium (RPE) cells in the vitreous on several sections. The laser-treated eyes had a firm, wide chorioretinal adhesion, with minimal tissue disruption and no release of RPE cells. No complications occurred. CONCLUSION: We conclude that indirect-ophthalmoscope-directed diode laser retinopexy was safe and efficacious for globe perforation during strabismus surgery on rabbits and could be expected to be useful in humans.

Animals↗

High resolution, dynamic, magnetic resonance imaging in complicated strabismus.

Strabismus cases, especially after previous surgery or trauma to extraocular muscles, often present diagnostic challenges. Conventional clinical tests are helpful in some cases but may be inconclusive. High resolution, dynamic, orbital magnetic resonance imaging (MRI) may yield additional critical information about orbital and extraocular muscle anatomy and function. We report four complicated strabismus cases for which dynamic surface coil MRI helped formulate a precise diagnosis and the most appropriate surgical plan.

Adult↗