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700 records · Page 39Linked to original sources
PubMedDate not supplied

[Biological age, adrenoreception and lipid peroxidation in patients with ischemic heart disease].

The article deals with electro-kinetic potential of cellular nucleus considered as an indicator of unspecific reactivity and presents some data on molecular and cellular mechanisms of adreno- and muscarino-receptive interactions, such as adrenalin, noradrenaline and DOPA blood levels, lipid peroxidation, erythrocyte resistance to peroxidation. The attempt is made to comprehend directions and trends of aforementioned processes in patients with stable and unstable stenocardia as well as in myocardial infarction with regard to sex and influence of central M-cholinoblockader amizyl. The drug provides adaptive effect, corrects affected adreno-reception, protects biomembranes from lesion, promotes their "fluidity" and reduces rigidity.

Adult↗
PubMedDate not supplied

[Role of the central and peripheral cholinoreceptors in the processes of short-term memory].

Short-term memory with blocked cholinoreceptors was studied by the method of deferred reactions in the choice of one of 3--4 feeding troughs in tests staged on 5 dogs and 5 cats. Disturbances of short-term memory were caused by blocking of central m-cholinoreceptors with benactizyne (0.1--0.4 mg/kg). On abolishing peripheral symptoms arising under the effect of chlorpromazine with carbocholine (0.001 mg/kg) the short-term memory disturbances go on persisting. Blocking of peripheral m-cholino-receptors with lachesine (0.01--0.1 mg/kg) does not have any significant effect on the short-term memory. Under the blocking action of pediphen (0.5--2 mg/kg) on the cerebral n-cholinoreceptors the short-term memory improves with reduced memorization capacity.

Animals↗
PubMed1976

[Effect of gravitational stresses on morphologic changes in the lymphatic bed of the guinea pig cecum during blockade of M-cholinoreactive systems].

The work has been performed in the material taken from 40 quinea pigs whose lymphatic bed was injected by Gerota's mass. The material was treated by macro-microscopical methods and the method of luxmetry. A single exposure to gravitation stress of ventro-dorsal direction caused probounced morphological changes in all links of the lymphatic bed of the guinea pig's coecum. Exclusion of the central and peripheral M-cholinoreactive systems of the organism by means of scopolamin in doze 50 mkg/kg had a protecting effect on the coecum lymphatic bed in the following exposure to gravitation stress.

Animals↗
PubMed1993

[The participation of the cholinergic structures of the prefrontal and inferotemporal cortices in visual recognition processes in monkeys].

Characteristics of visual recognition were impaired by amysil influence in monkeys. This was accompanied by a considerable activation of unit activity in the prefrontal cortex. Amysil induced a considerable drop in the cross-correlation coefficients between simultaneous responses of neuronal populations in prefrontal and inferotemporal cortex.

Acoustic Stimulation↗
PubMedDate not supplied

[Effect of neurotropic substances on a change in evoked potential amplitude following hypothalamic stimulation].

Records of evoked responses to clicks in the cortex, reticular formation and hippocampus as well as determination of thresholds of hypothalamus stimulation eliciting fear and rage reactions, have shown that after emotional excitation the hypothalamus excitability is enhanced and the thresholds of perception of foreign signals are higher causing a slackening of attention to them. Trifluoperasine and galoperidol in a dose of 0,5 mg/kg, diazepam (0.5 and 1,0 mg/kg), benactizine (0,5 and 1,0 mg/kg), chlordiazepoxid (2.5 and 5 mg/kg), amitriptiline (2,5 and 5,0 mg/kg), imipramine (2,5 and 5,0 mg/kg) normalize the attention after emotional excitation by reducing the excitability of the hypothalamus. Pentobarbital (1,0 and 2,0 mg/kg), chlorpromazine (0,5 and 1,0 mg/kg) as well as trifluorasine and galoperidol in a dose of 1,0 mg/kg, deepen the attention disturbances after emotional excitation due to a blockade of inhibitory effects of the basolateral amygdala and dorsal hippocampus on the hypothalamus.

Amitriptyline↗
PubMedDate not supplied

[Changes in the brain neuraminidase activity under the action of tsiklozil and amizil].

The effect of cyclozyl and amizyl on the activity of soluble and membrane-bound neuraminidase of the rat brain is studied in the in vivo and in vitro experiments. Within 60 min after subcutaneous injection of cyclozyl in a dose of 0.5 microgram/kg of body weight the activity of soluble neuraminidase decreased by 45.5% whereas the activity of membrane-bound neuraminidase remained the same. In the experiments in vitro the activity of both enzyme forms did not change when the content of cyclozyl and mixture of general gangliosides in the incubation media was 2.0, 20.0, and 200.0 micrograms. Amizyl (2 micrograms) in the presence of general gangliosides increased the neuraminidase activity whereas in the presence of disialoganglioside GD1b reduced the activity. Various lipids (phospholipids, phospholipids + cholesterol, cerebroside + sulfatides) surrounding the enzyme exerted different effect on the activity of both neuraminidase forms. Thus we suggest active interaction of the system "gangliosides-soluble and membrane-bound neuraminidase" with M-cholinolytics (cyclozyl and amizyl) and important role of this "substate-enzyme" system in M-cholinoreceptor functioning.

Animals↗
PubMed1976

[The tranquilizing properties of sodium hydroxybutyrate].

Experiments were conducted on rats. It was shown that sodium oxybutyrate depressed the escape response to punishment of the partner and motivated aggression in much lower doses than the defence conditioned reflex and unmotivated aggression, prevented negative consequences of fear and rage reactions; it also normalized conditioned reflexes in neurotic rats, this pointing to its marked tranquillizing action.

Aggression↗
PubMed1997

[The specific nature of the cholinergic mechanisms of short-term memory in monkeys for different types of visual information: the characteristics of the effect of amizil].

Short-term storage of visual information in monkeys seems to be determined by a set of cholinergic mechanisms, each of them dealing with a certain type of visual objects. These mechanisms are involved into the visual information processing and forming spatial discriminative features caused by the visual-vestibular interaction.

Animals↗
PubMed1998

[The effect of pharmacologic prophylaxis with Panpal on acetylcholinesterase activity in the diaphragm and various parts of the brain in rats during treated and untreated Soman poisoning].

BACKGROUND: The pharmacological prophylaxis protecting the organism against organophosphorus compounds could increase the effect of antidotal treatment of poisoning with organophosphates. METHODS AND RESULTS: The influence of the pharmacological prophylaxis with Panpal (pyridostigmine in combination with benaetyzine and trihexyphenidyle) on acetylcholinesterase activity in diaphragm and various parts of brain at 1 and 3 h following non-treated and treated (the oxime HI-6 in combination with atropine) soman poisoning was tested on male rats. While Panpal did not significantly influence the acetylcholinesterase activity in brain following non-treated as well as treated soman poisoning. Panpal increased so many-induced acetylcholinesterase inhibition following non-treated poisoning and decreased the reactivating effect of the oxime HI-6 following treated soman poisoning in diaphragm. CONCLUSIONS: Our data confirm the importance of the combination of reversible acetylcholinesterase inhibitor pyridostigmine with anticholinergic drugs in the pharmacological prophylaxis of soman poisoning because of the elimination of consequences of pyridostigmine-induced increasing in acetylcholinesterase inhibition in the peripheral compartment.

Acetylcholinesterase↗