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PubMed1988

[Status of the coronary vessels and functional state of autovenous shunts in patients with ischemic heart disease at remote periods after aortocoronary bypass].

Repeated coronarography in 89 coronary patients at late dates after aortocoronary shunting, including 74 (83%) patients with residual or recurrent angina and only 15 (17%) angina-free patients, demonstrated that the progress of atherosclerosis continued in both the shunted and intact coronary arteries after the operation. Thrombosis of autovenous shunts had a pronounced effect on clinical condition of the patients. Only 50% of the shunts were open in patients with residual or recurrent angina, while bypass patency was 81% in the absence of anginal attacks.

Coronary Artery Bypass↗
PubMed1981

[Inhibitory effect of metformin on the development of cholesterol atherosclerosis in the rabbit. Observations on the coronary vessels].

Experimental atherosclerosis and atheroregression may appear at different levels of development in the different arterial districts of non-human primates. The coronary arteries that are involved, like aortas, in the atherogenic process are, in the monkeys, less prone to atheroregression. The atherosclerotic lesions which are always present in the coronary arteries of the hypercholesterolemic rabbits are not evident in the coronaries (at extra- as well at intracardiac level) of the hypercholesterolemic rabbits treated with metformin.

Animals↗
PubMed1988

Angiographic and clinical predictors of acute closure after native vessel coronary angioplasty.

To determine predictors of acute coronary closure after PTCA performed with steerable catheter systems, we compared 140 procedures complicated by acute closure and 311 representative successful attempts from 4,772 procedures performed between April 1982 and March 1986. Sixteen clinical, 35 angiographic, and seven procedural variables were analyzed. Multivariate analysis found seven independent preprocedural factors related to closure: stenosis length of 2 or more luminal diameters, female gender, stenosis at a bend point of 45 degrees or more, stenosis at a branch point, stenosis-associated thrombus (filling defect or staining), other stenoses in the same vessel, and multivessel disease. In addition, four procedural factors were found to be associated with closure by univariate analysis: post-PTCA percent stenosis (p less than .001), intimal tear or dissection (p less than .001), use of prolonged heparin infusion (p less than .001), and post-PTCA gradient of 20 mm Hg or more (p = .004). Multivariate analysis of both preprocedural and procedural variables found six factors independently related to closure: post-PTCA percent stenosis, dissection, prolonged post-PTCA use of heparin, branch point location, fixed bend point location, and other stenoses in the vessel dilated. The risk of coronary closure after PTCA has many determinants. While an estimation of risk can be made before performing PTCA, the most powerful predictors of closure can only be assessed during the procedure itself.

Acute Disease↗