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At least 703 records · Page 39Linked to original sources
PubMed1992

Cerebral palsy: improved outcome by early detection of latent failure of psychomotor development in infants.

A prospective cohort study was performed to evaluate the results of a new screening system for latent psychomotor disturbances in infancy developing into cerebral palsy (CP). The system has been based on an early diagnosis within the first 2 months of life with a subsequent follow-up. All liveborn children were screened and suspect cases were immediately referred to detailed neurological examination. With the new screening system implemented within 1988 to 1989, the incidence of cerebral palsy in the area could be halved as compared to 1980 to 1986 (0.26% vs. 0.52% of liveborn children respectively). Out of 4,166 liveborn children, 527 newborns had to be referred to neurologic examination, thereof 460 required follow-up and 228 had to be treated. In only 11 of the children CP was diagnosed at the age of 15 months. 8 of the CP children presented signs of serious neurologic disturbance at birth and were considered as "requiring high-tech use". A latent psychomotor disturbance developing slowly into CP during the first year of life occurred but in 3 children, 2 of them having relatively favorable prognosis; this group was termed as "requiring skilled clinical organization". Premature children (under 37 weeks of gestational age) had an 82% share on our recent CP patients.

Cerebral Palsy↗
PubMed1982

A simple high calorie high protein feed for low birth weight infants in developing countries.

A simple high calorie high protein feed was devised by the addition of Caloreen and egg white to milk feeds for use in low birth weight infants (low birth weight--LBW). The growth rate was studied in 100 LBW infants. A weight gain of 203 g per week was obtained as compared to 110 g in the control group; growth was 8.6 mm in the study group as compared to 6.4 mm in the control group; the occipitofrontal circumference (OFC) was 0.67 mm in the study group and 0.38 mm in the control group. All differences were statistically significant.

Developing Countries↗
PubMed1987

Early language development in infants with cortical and subcortical perinatal brain injury.

To understand better the cognitive sequelae of mild perinatal brain injury, we studied three groups of high-risk infants, using the Early Language Milestone Scale (ELM Scale). Premature infants with Grades I and II intraventricular hemorrhages (IVH) were delayed on the expressive but not the receptive subscale of the ELM Scale. Mildly asphyxiated full-term infants were slightly delayed on both the expressive and receptive subscales. Premature infants without IVH performed the same as the normal sample on which the scale was based. Although normal intellectual functioning has been reported in infants with Grade I-II IVH, this study demonstrates early specific deficits in expressive language in these children. These results are discussed in relation to localization of language in the adult brain, and the influence of subcortical structures on development and maturation of the cortex.

Asphyxia Neonatorum↗
PubMed1996

Labor analgesia and infant brain development.

A large percentage of newborns are exposed to pharmacological agents that affect the brain in connection with pain management during labor. The two most commonly used agents are meperidine, administered intravenously or intramuscularly, and bupivacaine, administered by the epidural route. Over the years, infant behavioral assessments have been used in the neonatal nursery to identify labor analgesia regimens with minimal impact on neonatal status. However, considerable controversy has centered on the general issue of possible harm to the neonate from use of analgesia and anesthesia in obstetrics. Due to limitations on experiments in the obstetric situation and a lack of suitable animal models, the broader issues concerning the effects of these agents on the developing brain and possible long-term consequences for infant adaptive functioning have received little attention. A series of studies has recently been completed using a rhesus monkey model for administration of labor analgesia under controlled experimental conditions and long-term behavioral evaluation of infants. Most of the assessments, including those of cognitive function, were not influenced by perinatal analgesia. However, these studies have confirmed the neonatal depressant effects of meperidine and have suggested that the course of behavioral maturation during certain periods of infancy is influenced by both meperidine and bupivacaine administration at birth. These effects could occur as a result of effects on vulnerable brain processes during a sensitive period, interference with programming of brain development by endogenous agents, or alteration in early experiences.

Analgesia, Obstetrical↗
PubMed1981

Visual acuities in infants with congenital cataracts operated on prior to 6 months of age.

Seven infants with complete bilateral cataracts were operated on and fitted with extended-wear silicone contact lenses. The infants were matched to 16 normal control subjects. A modified preferential looking technique was used to assess visual acuity; the Bayley Scale of infant Development was administered to measure psychological development. Of the seven infants with cataracts, those operated on prior to 8 weeks of age seemed to have normally developing vision. All others showed a substantial visual lag when compared with the control group. Bayley scores for infants operated on early (before 8 weeks) fell within the range of normal variability. The infants operated on later demonstrated a statistically significant lag in development. Also, a pendular nystagmus was noted in those infants with cataracts who were operated on later.

Age Factors↗
PubMed2003

Knowing about knowing: dissociations between perception and action systems over evolution and during development.

Studies of human patients reveal dissociations between perception and action; some patients have implicit knowledge for a given domain, but can't access this knowledge for action. Studies of human infant development reveal a similar dissociation, suggesting that the neural systems connecting action with perception are not formed until the early preschool years, perhaps later. These connections are fundamental to our knowledge, to what we know about what we know. In this chapter I discuss the evolution of this knowledge, and argue that the dissociations seen in patients and in infant development are also seen in normal adult nonhuman primates, especially in the domain of folk physics. This suggests that for some domains of knowledge, animals don't know what they know. The disconnect between perception and action leads, in some cases, to perseverative errors. These errors, in turn, provide the signature of a highly encapsulated, modular system.

Biological Evolution↗
PubMed1997

Effects of thyroxine supplementation on neurologic development in infants born at less than 30 weeks' gestation.

BACKGROUND: Premature infants who have transient hypothyroxinemia in the first weeks of life may have developmental delay and neurologic dysfunction. Whether thyroxine treatment during this period results in improved developmental outcomes is not known. METHODS: We carried out a randomized, placebo-controlled, double-blind trial of thyroxine supplementation in 200 infants born at less than 30 weeks' gestation. Thyroxine (8 microg per kilogram of birth weight) or placebo was administered daily, starting 12 to 24 hours after birth, for six weeks. Plasma free thyroxine concentrations were measured weekly for the first eight weeks after birth. Scores on the Bayley Mental and Psychomotor Development Indexes and neurologic function were assessed at 6, 12, and 24 months of age (corrected for prematurity). RESULTS: Mortality and morbidity up to the time of discharge from the hospital were similar in the study groups. At 24 months of age, 157 infants were evaluated. Overall, neither mental nor psychomotor scores differed significantly between the study groups at any time, nor was the frequency of abnormal neurologic outcome significantly different. In thyroxine-treated infants born at gestational ages of less than 27 weeks, the score on the Bayley Mental Development Index at 24 months of age was 18 points higher than the score for the infants with similar gestational ages at birth in the placebo group (P=0.01); for thyroxine-treated infants born at 27 weeks or later, the mental-development score was 10 points lower than that of their counterparts in the placebo group (P=0.03). There was no relation between the initial plasma free thyroxine concentration and the effect of treatment. CONCLUSIONS: In infants born before 30 weeks' gestation, thyroxine supplementation does not improve the developmental outcome at 24 months.

Central Nervous System↗
PubMed1993

The ontogeny of the gut mucosal immune system and the susceptibility to infections in infants of developing countries.

In this review we summarize data on the human gut mucosa associated lymphatic tissues as part of the common mucosal immune system. Its embryonal-fetal and post-natal ontogeny becomes severely distorted and compromised by mal-/undernutrition which is so prevalent in developing countries. Pathogenetic interdependencies exist between maternal-fetal undernutrition, the ontogeny of the immune system, constant antigenic stimulation of the mucosal immune system post-natally, and the 14 million deaths annually from infections in children below the age of 5 years in developing countries. A detailed knowledge of these interdependencies is required for effective prevention and treatment in an attempt to reduce the high morbidity and mortality rates of children in developing countries.

Animals↗
PubMed2007

Mental development of infants with congenital hypothyroidism: a longitudinal study.

The purpose of this study was to assess the relationship between the clinical findings before starting treatment and the development quotient in children treated for congenital hypothyroidism. Patients with congenital hypothyroidism (n = 129) were divided into favorable and unfavorable groups according to intellectual performance. Children with congenital hypothyroidism generally have a similar intellectual outcome to that of healthy children. However, a low birth weight, the presence of complications, and a high serum thyroid-stimulating hormone value are the risk factors for unfavorable cases, who consistently have a development quotient score of less than 100.

Child, Preschool↗
PubMed2005

Extreme hyperbilirubinaemia in term and near-term infants in Denmark.

AIM: To determine the incidence amongst infants born at term or near-term of extreme hyperbilirubinaemia, i.e., with a serum concentration of unconjugated bilirubin exceeding the limit above which an exchange transfusion was indicated according to the authorized guidelines. METHOD: The investigation period covered 2 y, 1 January 2000 to 31 December 2001, and included all infants born alive at term or near-term in Denmark. All infants with extreme hyperbilirubinaemia admitted to paediatric departments were recorded. RESULTS: Thirty-two infants developed extreme hyperbilirubinaemia, i.e., an incidence of 25 per 100 000. The maximum total serum bilirubin concentration (TSB) was 492 (385-689) micromol/I (median (range)). The median value of the exchange transfusion limits was 450 micromol/l. Twelve infants had signs and symptoms of central nervous system involvement; 11 had acute bilirubin encephalopathy phase-1 symptoms; and one had phase-2 symptoms. Nineteen infants developed extreme hyperbilirubinaemia during primary admission to the maternity ward or neonatal department; the others after having been discharged. There was no difference in maximum TSB between those infants not discharged from hospital and those infants admitted to hospital from home. Maximum TSB appeared latest amongst those infants admitted from home (p < 0.01), and these more often had signs and symptoms of central nervous system involvement (p < 0.05). Ten infants were of non-Caucasian extraction. Less than half of all Danish mothers receive both verbal and written information after birth on jaundice in the infant. CONCLUSION: Twenty-five per 100 000 infants born at term or near-term developed extreme hyperbilirubinaemia, the majority of them whilst in hospital. Infants admitted from home more often had signs and symptoms of central system involvement.

Bilirubin↗
PubMed1983

Growth and development of infants weighing less than 800 grams at birth.

A prospective study of infants weighing less than 800 g at birth and cared for in a single neonatal intensive care unit between 1977 and 1980 was conducted. Neonatal mortality was 80%; neurodevelopmental outcome was assessed in 16 of the 18 survivors. Mean birth weight for these 16 was 730 g; mean gestational age was 26 weeks. Perinatal asphyxia, respiratory distress, apnea, mechanical ventilation, and chronic pulmonary disease were commonplace. Symptomatic intracranial hemorrhage, seizures, sepsis, or meningitis did not occur in survivors. Of the 16 infants, 13 (81%), including all three with birth weight less than 700 g, were without major CNS handicaps and were developing appropriately at 6 months to 3 years of age. Only one of the 16 had clearly subnormal mental development. None had a major visual or hearing impairment. Apgar scores at one and five minutes were significantly related to outcome; apnea, mechanical ventilation, and chronic pulmonary disease were not. These data suggest that a remarkably hopeful outcome is possible for the few survivors of extremely low birth weight.

Apgar Score↗
PubMed2002

Cognitive and social factors in the development of infants with Down syndrome.

Infants and young children with Down syndrome can be engaging and affectionate. It seems that in the early months of life their personal relations may be relatively 'spared' the effects of limitations in their capacities for information-processing. Yet how far is this the case as development proceeds? In this paper we discuss some ways in which social and cognitive development interact and mutually influence one another over the first year or so of life, and present preliminary findings from a longitudinal study of infants with and without Down syndrome. The evidence suggests that the development of 'triadic' (person-person-world) social interactions may be affected by limited information-processing capacities in infants with Down syndrome, through a complex socially-mediated developmental trajectory.

Attention↗