PubMed1980
The authors studied elementary and complex forms of contact sensitivity in 48 schizophrenic patients with different psychopathological syndromes prior to, in the process and after neuroleptical therapy. It was demonstrated that in 34 patients following the 5-14 day of treatment there were different sensory disorders, while in 6 patients with sensory disorders marked even before treatment, these disorders in the process of neuroleptical therapy either were aggravated, or modified. The sensory disorders were dynamical, bilateral and involved different brain levels. As a rule they appeared in patients with a clinical picture of disorders of perception. The quality of remissions correlated with the traits of sensory disorders. Motor extrapyramidal changes in these patients were more frequent than sensorial and differed in the time of appearance, dynamics, degree of expressiveness and prevalent level of lesion. The assumption of direct influence of neuroleptical drugs on the sensory sphere was also confirmed by the traits of sensory disturbances which depend upon the clinical signs and spectrum of psychotropic action in different neuroleptics. Sensory disorders appearing during neuroleptical therapy may be qualified as a neuroleptical sensory syndrome.