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Evaluation of a new dentifrice for the treatment of sensitive teeth.

A dentifrice containing 5% potassium nitrate, 1.3% soluble pyrophosphate, 1.5% polyvinylmethyl ether and maleic acid (PVM/MA) copolymer and 0.243% sodium fluoride in a silica base (Sensitive/Tartar Control) has been developed to concomitantly control tartar, caries and dentinal hypersensitivity. In vitro and animal studies show that the fluoride in this product effectively inhibits formation of enamel and dentine caries. In vitro studies also demonstrate that this dentifrice effectively reduces hydraulic conductance by occluding dentine tubules with a mixed surface deposit of copolymer and silica. Using an in vitro model that simulates in vivo conditions, this dentifrice also allows a rapid penetration of potassium nitrate through the dentine matrix. These findings demonstrate a correlation under in vivo conditions between the occlusion of dentine and the ability to deliver topically applied agents to target sites within or below dentine. The results indicate that this new dentifrice should provide multiple clinical therapeutic benefits including controlling tooth decay and tartar formation, and reducing and preventing dentinal hypersensitivity.

Animals↗

Anticaries efficacy of an improved stannous fluoride toothpaste.

A series of laboratory and animal studies were conducted to confirm the anticaries potential of a new, stabilized stannous fluoride (SnF2) dentifrice relative to clinically proven SnF2 controls. Included in this series of assessments were fluoride uptake into demineralized human enamel, remineralization/inhibition of demineralization for both human enamel and roots, and animal caries studies. Each of these studies demonstrate the new, stabilized SnF2 dentifrice (Crest Gum Care toothpaste) is effective at inhibiting and reversing the caries process. These data confirm that this new dentifrice, formulated with a combination of SnF2, and hydrated silica, is predicted to be highly effective against caries. These tests predict that this new stabilized SnF2 dentifrice (Crest Gum Care toothpaste) provides a level of anticaries activity that is equivalent to Crest Regular toothpaste, a sodium fluoride (NaF)/silica product. The data suggest that this new formulation provides enhanced anticaries efficacy relative to previous, unstabilized SnF2 formulations as a result of improved fluoride bioavailability.

Analysis of Variance↗

Report on the RCDS-CDHSRU workshop on developing clinical guidelines/standards of practice.

Investigators from the Community Dental Health Services Research Unit (CDHSRU) held a workshop to test a model for developing clinical guidelines/standards of practice, which are required under the Regulated Health Professions Legislation. Forty-two individuals from Ontario and Canada, including dentists, representatives of the public, and professionals, participated in the three-day workshop, held under the auspices of the quality assurance committee of the Royal College of Dental Surgeons of Ontario (RCDS). Through direct experience, workshop participants sought to learn each of the steps, as defined by the literature, involved in clinical guideline development. Ultimately, they hoped to recommend steps for RCDS to follow in developing standards of practice. To ensure that a realistic and valid model emerged from the workshop, a real topic, namely the management of smooth surface enamel lesions in permanent teeth, was used to develop and test clinical guidelines. Prior to the workshop, participants were sent literature on one of five aspects of the topic, as well as papers describing the methodology of critically appraising the literature, and partially-completed templates outlining the basic steps to be followed. During the first evening and first morning of the workshop, participants listened to presentations on the development of clinical guidelines, the prevalence of smooth surface lesions, the role of economics in guideline development, and the necessary considerations in writing clinical guidelines. Under the leadership of trained facilitators, they then worked in small groups to write evidence-based recommendations and report them to the other workshop participants for feedback. Using this feedback, they returned to their groups to revise their recommendations and work on the workshop's overall recommendations to the RCDS. The day concluded in the evening, when the workshop facilitators and coordinators met to edit the groups' recommendations into a consistent format for presentation to all participants. On the second morning, the participants attended a plenary session to review the evidence-based recommendations developed by the groups, as well as their overall recommendations on the steps to be followed by the RCDS. Ultimately, workshop participants partially completed the templates and developed preliminary evidence-based recommendations on the management of enamel smooth-surface caries. Based on their experiences, they recommended a seven-step process for the future development of clinical practice guidelines/standards of practice in Ontario. These steps are recommendations only, and are not RCDS policy.

Canada↗

FluoriSHIELD.

Explore the source record for details and available documents.

Buffers↗

The influence of a mineralizing mouthrinse on the mineral contents and on the pH of dental plaque.

The main objective of this study was to evaluate the effects of a single use of a mineralizing mouthrinse on dental plaque pH and on its mineral contents: an additional objective was to examine the effects of an oral prophylaxis and scaling on the same response variables. A total of 22 volunteer dental students (14 female and 8 male) participated in the study. The mineralizing mouthrinse contained calcium, phosphate, strontium and fluoride ions. Following a 48-hour period without oral hygiene and 2 hours after breakfast, dental plaque was collected twice from each participant for the evaluation of the effects of the oral prophylaxis and scaling, and twice more for the evaluation of the effects of the mineralizing mouthrinse. The pH was measured in vitro with a microelectrode and the mineral contents were determined by atomic emission spectrometry. The results demonstrate that the average post-prophylaxis pH was higher than the average pre-prophylaxis pH, and that a variation of the average contents of some minerals in the dental plaque was also observed after prophylaxis compared to the contents prior to prophylaxis. Although there was a significant reduction in the Fe content after the rinse with the mineralizing solution, no significant variation on the average pH was detected.

Adolescent↗

Recommendations for fluoride use in children. A review.

Fluoride has played a significant role in the improvement of the oral health of all Americans. Because of its effectiveness, cost and frequency of exposure, water fluoridation is the preferred method of delivery. Today, many products containing fluoride are available over the counter and as prescription items. The potential for exposure to multiple sources of fluoride has increased. Therefore, practitioners should prescribe fluoride therapy based on an understanding of patients' total exposure to fluoride and the need for additional amounts.

Adolescent↗

[The clinical evaluation of the quality of tooth filling after exposure to hydroxyethylidene diphosphonic acid].

Ultrastructure of dental enamel was examined under electron microscope after exposure to hydroxyethylene diphosphonic (HEDP) acid and prophilometry of enamel surface was carried out after its exposure to acid salts; clinical studies in 105 patients aged 18-50 years with different diseases of hard dental tissues were carried out in order to assess the duration of filling preservation after dental enamel treatment with HEDP salts. Clinical results were assessed from subjective sensations of patients and data of examination. The criteria of assessing the results were presence of a filling in a filled carious cavity, marginal adhesion of the filling, alteration of color along the external interface of the filling, caries relapses, status of dental pulp and periapical tissues. Clinical and laboratory studies showed that treatment with HEDP acid creates favorable conditions for tooth filling.

Acid Etching, Dental↗

Effects of collagenase on root demineralization.

The role of proteolytic enzymes in the root caries process remains unclear. The aim of this study was to investigate collagenase activity during tooth root demineralization and remineralization in an in vitro demineralization/remineralization pH-cycling model, Human tooth roots were subjected to pH cycling (alternating demineralization and remineralization) in one of two different time cycles for five days. Collagenase at 90, 180, or 360 micrograms per root was placed into either the demineralizing solution or the remineralizing solution in the pH-cycling system. The effects of additional exposure to collagenase before or after pH cycling were also studied. After the exposure, thin sections of the roots were examined histologically by polarized light microscopy. Changes of calcium and phosphate in the solutions were analyzed chemically. Surface erosion occurred only in the groups where collagenase was contained in the remineralizing solution and in which the root samples were exposed to severe demineralization. However, no differences among the control and experimental groups were found in calcium and phosphate changes in the pH-cycling solutions. These findings suggest that collagenase works during the remineralizing phase and predominantly attacks the organic matrix of the root after demineralization. Additional exposure to collagenase before or after pH cycling did not increase surface erosion except for exposure to collagenase in the absence of phosphate following pH cycling.

Calcium↗

Minimal intervention: early lesions.

The use of modified cavity designs for the treatment of initial carious lesions can be justified on the grounds that, because no restorative material can adequately replace natural tooth structure for the long term, preservation of natural tooth structure is important. It is apparent that it is possible to remineralize and heal demineralized tooth structure to some degree. Therefore, neither enamel nor dentin should be removed simply because it has lost calcium and phosphate ions as a result of acid attack. The older surgical approach to cavity design was adopted in the absence of adhesive techniques and on the basis of Black's principle of "extension for prevention," but this theory is no longer tenable. The current availability of adhesive bioactive restorative materials makes it possible to maintain areas of tooth structure even though they appear to be undermined and weakened. Thus, the concept of geometric designs for prescribed cavities is no longer valid. The purpose of this article is to describe a series of simplified, modified cavity designs for small initial lesions; preservation of natural tooth structure is the principle objective of these designs.

Dental Caries↗

Effects of phosphoprotein moieties on the remineralization of human root caries.

The noncollagenous proteins, especially phosphoprotein, have been shown to modulate biomineralization. The objective of this study was to investigate the remineralization potential of human tooth root organic matrices which did or did not contain soluble non-collagenous proteins including phosphoprotein. Human tooth roots were completely demineralized using conditions that either removed or did not remove soluble phosphoprotein and were then subjected to remineralization conditions. Removal of soluble phosphoprotein resulted in remineralization while no remineralization occurred in tooth roots that still contained soluble phosphoprotein. Transmission electron microscopy and microradiography demonstrated that demineralized cementum did not remineralize under any of the conditions used in this study. Collagenase digestion of demineralized and salt-reextracted tooth root organic matrices revealed that a nonsoluble phosphoprotein was present in the matrices. Amino acid analysis and SDS-PAGE showed that this nonsoluble phosphoprotein was similar in composition to the soluble phosphoprotein. This work suggests that the removal of soluble, noncollagenous proteins, especially phosphoprotein from root caries lesions, may enhance their remineralization potential.

Amino Acids↗

[Determination of Ca2+ content in human enamel by electroprobe after polypeptide tooth paste usage].

OBJECTIVE: The purpose of this study was to investigate the capability of polypeptide tooth paste for remineralization of human enamel. METHODS: 8 enamel slabs,which were taken from extracted tooth for orthodontics reason, were immersed in artificial cariogenic solution for 0.5h. Then,the slabs were treated by tooth paste with polypeptide and tooth paste without polypeptide for 5 min. After tooth paste were washed away by warm water, the slabs were immersed in artificial saliva. The experiment were carried out twice per day for 15 days. Two slabs were taken from test group(treated by tooth paste with polypeptide) and control group (treated by tooth paste without polypeptide) on the twelfth day and fifteenth day, respectively. The Ca(2+) content in enamel slabs were determined by electroprobe and analyzed by image process. RESULTS: The content of Ca(2+) in test group was higher than that in control group significantly. CONCLUSION: The polypeptide tooth paste has certain capability of inhibiting demineralization for human enamel.

English Abstract↗

[An approach to removing stains and remineralization of dental fluorosis].

341 mottled teeth were bleached with 4% and 18% hydrochloric acid; the mixture of 36% hydrochloric acid, 30% hydrogen peroxide and anesthetic ether; and 30% hydrogen peroxide warmed by infra-red ray lamp. The effects were evaluated clinically. The extracted mottled and normal teeth were treated with the methods mentioned above. The decolouration effects, the structural changes of tooth surface, and the remineralization were examined by scanning electronmicroscopy and polaroid microscopy. The results showed: all of the four methods had the decolouration effects; the decolouration effect was better in the teeth with higher mineralization and the pigmentation existed more superficially; complete decolouration was 94.8% and lightened cases were 5.2%. The mechanism of decolouration seemed to be the dissolution of tooth superficial layer containing pigment. The decalcified tooth surface might be recalcified by the treatment of recalcification solution, or by saliva itself.

Adolescent↗

Quantitative assessment of the efficacy of amorphous calcium phosphate/methacrylate composites in remineralizing caries-like lesions artificially produced in bovine enamel.

Recent studies show that methacrylate-based composites with amorphous calcium phosphate (ACP) as a filler can release supersaturating levels of calcium and phosphate ions in proportions favorable for apatite formation. These findings suggest that such composites could be effectively used as coatings for remineralizing teeth damaged by tooth decay. To examine this hypothesis, we tested composites in vitro for their efficacy to remineralize artificially formed caries-like lesions in extracted bovine incisors. Single 120-microns-thick sagittal tooth sections were placed in holders that exposed only the carious enamel surface. The exposed surfaces were coated with a 1-mm- to 1.5-mm-thick layer of the composite containing, by mass, 40% apatite, silica, or P2O7(-4)-stabilized ACP and 60% photoactivated resin comprised of Bis-GMA, TEGDMA, HEMA, and ZrM. The photocured composite-coated sections were immersed either in a remineralizing solution for 4 weeks at 37 degrees C (static model) or cyclically immersed in demineralizing (0.5 h) and remineralizing solutions (11.5 h) for 2 weeks (dynamic model). Quantitative digital image analysis of matched 102 microns x 220 microns areas from contact microradiographs taken of the sections before and after immersion showed that lesions coated with ACP-filled composites fractionally recovered 71% +/- 33% of their lost mineral compared with 14% +/- 13% for apatite controls in the static model and 38% +/- 16% compared with -6% +/- 24% in the dynamic model. The results suggest that sealants based on ACP-filled methacrylate composites have the potential to remineralize carious enamel lesions.

Animals↗

Fluoride varnishes.

Fluoride varnishes are available in the United States, and the Federal Drug Administration has approved a fluoride varnish for use as a cavity preparation lining varnish and as a tooth desensitizing agent. The literature, however, supports the use of fluoride varnishes to inhibit tooth demineralization and enhance remineralization. The purpose of this paper is to present an overview of literature and make recommendations according to the available scientific evidence. Findings support the use of fluoride varnishes as a safe and effective topical fluoride agent.

Cariostatic Agents↗