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Results for “11-Hydroxycorticosteroids”

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PubMedDate not supplied

[Effect of ascorbic acid on glucocorticoid metabolism in guinea pigs].

Ascorbic acid administered for 18-20 days (daily by 100 mg per 1 kg of weight per os) causes redistribution of certain fractions of 17-OCS excreted with urine (a decrease in the content of free F and F/E ratio, an increase in the content of THF, THE and THS, a more frequent appearance of substances). In the blood plasm and adrenals concentration of 11-OCS rises. When determining the available functional reserves of the adrenal cortex under these conditions, an increase in the content of F, E and S unchanged forms is observed in response to ACTH administration as distinct from the initial state. The rise in concentration of 11-OCS in the adrenals and blood plasm is less pronounced than in the control. A conclusion is drawn that ascorbic acid affects metabolism of glucocorticoids and changes the reaction of the adrenaocortical system on the action of ACTH.

11-Hydroxycorticosteroids↗
PubMed1976

[Study of the relationship between the glucocorticoid function of the adrenal cortex and blood lipoproteins].

Single administration of hydrocortisone to rats led to elevation in the blood serum of lipoproteins of very low density; and repeated administration - of lipoproteins of very low density, low density and of high density. Lipoproteins with d less than 1.063 g/ml produced an inhibitory action on the production of steroid hormones by the adrenal glands of rats in vitro.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Correlation of hydrocortisone and corticosterone content in assessing the functional state of the adrenal cortex in varying forms of hypercorticism].

Separate determination of hydrocortisone and corticosterone in the blood of patients with the hypercorticism symptom-complex showed that elevation of the corticosteroid concentration could occur on account of similar elevation of the concentration of both hormones, or one of the hormones alone. Analogous data were observed in patients after ACTH administration. Dexamethasone administration caused a reduction of the hydrocortisone and corticosterone concentration in patients with Itsenko-Cushing's disease, but to a lesser degree than in healthy individuals. Administration of the preparation to the patients with juvenile dyspituitrism decreased the cortizol level, but corticosterone chiefly; as to the patients with the hypothalamic syndrome--only the cortizol level was reduced, the level of corticosterone remaining unchanged. Thus, the evidence obtained before and after the administration of the ACTH preparations and dexamethasone permitted to assess the adrenal cortex function more fully and to defect disturbances of the corticosteroid secretion of interest of the understanding of the clinical symptoms of the disease.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Functional activity of the adrenal cortex and thymus of mice of strains AKR, C57BL/6, C3H/He and C3Hf].

The authors studied the relationship between the functional activity of the adrenal cortex before and after the ACTH administration and the thymus mass in AKR, C57BL/6, C3H/He, and C3Hf mice. Blood 11-OCS level of these mice proved to differ in accordance with the differences in the 11-OCS production by the adrenal glands. There was revealed no expected inverse correlative dependence between the basal blood glucocorticoid content and the thymus mass. After ACTH administration the mouse species could be placed thus in order of increasing reaction of the thymus: AKR less than C3Hf less than C3H/He less than C57BL/6; this correlated positively with the level of 11-OCS production by the adrenal glands and basal 11-OCS concentration in the peripheral blood.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Ultrastructure and function of zona fasciculata cells in the adrenal cortex of mice of differing genetic lines but physiologically normal].

Ultrastructure and function were studied of the cells of zona fasciculata of the adrenal cortex of male mice of strains CBA and C57B1. The results obtained point to potentially higher possibilities of the adrenal zona fasciculata in mice of strain C57B1. These data show the role of the genotype in determining the structure and functions of the cells of the adrenal cortex as well as an evident correspondence of the ultrastructural features to the specificity of functions and the level of activity of cells.

11-Hydroxycorticosteroids↗
PubMed1977

[Studies on gamma-oryzanol. III. Influence of gamma-oryzanol on circadian rhythms of serum gastrin, 11-OHCS and gastric secretion in rats (author's transl)].

In the course of investigations of gamma-oryzanol in rats, circadian rhythms in antiulcerogenic action on gamma-oryzanol were observed. Circadian rhythms in several other parameters were investigated and correlated with the antiulcerogenic action. Pretreatment of rats with gamma-oryzanol 100 mg/kg, s.c., for 5 days tended to decrease serum gastrin levels and gastric secretion, and to increase serum 11-OHCS. Suppresive patterns of serum gastrin and gastric secretion following the pretreatment with gamma-oryzanol corresponded to the circadian rhythms in antiulcerogenic action of gamma-oryzanol. A complication of our results suggests that increment of catecholamines in rat brain after gamma-oryzanol plays a role in the above mentioned actions.

11-Hydroxycorticosteroids↗
PubMed1975

Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency.

Seven urinary metabolites of tryptophan-kynurenine pathway were measured in riboflavin-deficient, pyridoxine-deficient, pair-fed and natural diet baboons. The most significant changes in the pyridoxine-deficient baboons was a mean sevenfold increase in the excretion of xanthurenic acid and a threefold decrease in 3-hydroxy anthranilic acid. The riboflavin-deficient baboons showed a twelvefold increase in the excretion of anthranilic acid, and a tenfold decrease in 3-hydroxy kynurenine. Red blood-cell pyridine nucleotides decreased only in the pyridoxine-deficient baboons, while plasma 11-hydroxy corticosteroids increased only in the riboflavin-deficient baboons. These results are discussed in relation to enzymatic changes that may be expected during these deficiencies.

11-Hydroxycorticosteroids↗
PubMed1979

[Structuro-metabolic mechanisms for integrating several endocrine organs].

Mechanisms of integration in the neuroendocrine system in the regimens of physiological rhythm (oestral cycle) and of isolated effect upon one link of the system (metapyrone administration) were studied with the aid of qualitative histoenzymological analysis of adenohypohysis and adrenal cortex, estimating the comoplex reorganization of various structural components of adenohypophysis and adrenal cortex in response to specific depression of glycocorticoid synthesis. The role of the so called unspecific reorganization in the maintenance of functional response to isolated effects upon certain endocrine functions is discussed along with the necessity of further studies on the principles of interaction in the endocrine system using morphofunctional analysis.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Effect of sealed chamber conditions on the functional state of the human adrenal cortex (based on data from a study of the 11-hydroxycortico-steroid content in the blood plasma)].

The effect of a changed atmosphere, hypoxia, hypercapnia, their combinations and different motor activities on the adrenocortical function was studied in 36 test subjects kept in an 8 m3 altitude chamber. Human adaptation to the environmental changes developed with an active involvement of the adrenal cortex. The level and direction of the changes depended on both the force of the influences and on the initial state of the test subjects.

11-Hydroxycorticosteroids↗
PubMed1979

[Hormone and mediator content in the blood of the adrenals and in the peripheral blood in hypertension].

The concentration of the fractions of corticosteroids, aldosterone, catecholamines, and cyclic nucleotides (cAMP and cGMP) in blood of the adrenal veins and the activity of renin in blood of the renal veins were studied in 22 patients with stages IIA and IIB hypertensive disease. At the same time the content of these substances in the peripheral blood was determined and compared with the level of steroid and catecholamine excretion in the daily urine. An increase in the content of free 11 OCS and F fractions in the peripheral blood and blood of the adrenal veins was revealed in all patients examined.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[The character of functional connections in the endocrine system of female white rats and their transformation with age].

The authors studied the functional interrelations between the adrenal glands and the thyroid gland of female albino rats of various age groups. Blood content of 11-oxycorticosteroids and protein-bound iodine was determined. Analogous determinations were carried out in partial exclusion of the adrenal gland function (metapyron block) and of the thyroid gland function (6-methyluracil block). It is supposed that in the young sexually-mature female albino rats the functions of the adrenal glands and the thyroid gland were in direct relationship irrespective of the cyclic variations in the sex steroid secretion; with the advance of age this association became deranged.

11-Hydroxycorticosteroids↗
PubMed1976

[Activity of adrenal cytoplasmic dehydrogenase following prolonged ACTH administration].

The activity of cytoplasmic dehydrogenases of the adrenal cells was examined during the prolonged injections of ACTH to Wistar rats. The indices of specific steroid synthesis function of the glands remained relatively high in the course of the whole experiment. Changes in the rats of corticosterone synthesis and dehydrogenase activities were phasic in character; they included an initial synchronic activation the first two days with its subsequent decrease (7 days of ACTH injections). The prevalence of activities of NADP-dependent dehydrogenases in combination with reactivation of steroidogenesis was marked during the concluding phase (13 days) of the experiment. A possibility of the adaptive role of selective activation of NADP-dependent enzymes in the maintenance of a high level of hormone biosynthesis under conditions of prolonged ACTH stimulation is discussed.

11-Hydroxycorticosteroids↗
PubMed1976

[Effect of long-lasting noise on the plasma concentration of catecholamines, glucocorticosteroids and PBI in pigs].

Exposure of pigs with a body mass of 25-30 kg to long-lasting motor noise (108 dB, 60-8000 Hz, 72 hours) results in a considerable increase of catecholamine concentration in the plasma. Coincidently there is a sharp continuous decrease of the 11-OHKS in the plasma during the whole period of exposure to noise. Immediately after stopping the acoustic irritation the concentration of plasma corticosteroids increases again. The electroencephalogram (EEG) giving evidence of inhibition signs during exposure to noise an adaptation effect of the information processing system is concluded. The increase of the PBJ during the period of acoustic stress points to an increased function of the thyroid gland but simultaneously it is considered to be an expression of the elevated adrenergic situation. By reason of the strong deviation of the three observed regulatory systems must be concluded that longer-lasting exposure to noise with the applied quality and intensity represents a stress situation for pigs having noise character as established for men. A possible influence on the productivity of the pork type pig by permanent acoustic stress is indicated.

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