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Results for “17-Hydroxycorticosteroids”

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PubMedDate not supplied

[Mechanism of the hypobilirubinemic action of nicofezon].

The effect of nicophesone on the processes of cojugation and alkaline phosphatase was studied in tests staged on albino rats and rabbits poisoned with carbon tetrachloride (CCl4). Nicophesone is shown to stimulate conjugation of bilirubin with glucoronic and sulphuric acids and to depress the activity of alkaline phosphatase. The data obtained are considered inasmuch as they concern the hypobilirubinemic action of nicophesone.

17-Hydroxycorticosteroids↗
PubMed1975

Adrenocortical activity and urinary cyclic AMP levels: effects of hypobaric hypoxia.

Six highly motivated and trained military test subjects were exposed to a simulated altitude of 4267 m (477 torr) for 48 hours, prededed and followed by sea level runs lasting 32 hours. During each scenario tests subjects were required to perform their respective military tasks on a continual basis with sporadic rest not exceeding several hours. Extremely high levels of plasma cortisol prior to the start of each session and persistently elevated concentrations of urinary 17-OH corticosteroids at sea level were consistently observed. (This observation probably explains the relatively minor changes in adrenocortical output noted during acute exposure to hypobaric hypoxia. Analogous results were obtained for urinary cyclic AMP, i.e. elevated baseline levels and minimal response to high altitude. The results indicate an attenuated response as well as an association between urinary measures of adrenocortical activity and cyclic AMP excretion.

17-Hydroxycorticosteroids↗
PubMed1975

Virilization associated with bilateral luteomas of pregnancy.

A case of maternal virilization associated with bilateral luteomas of pregnancy is described. Urinary 17-ketosteroids and plasma testosterone fell from markedly abnormal values to normal limits within 2 weeks of delivery. However, symptoms of virilization persisted in the postpartum state. A possible relation between polycystic ovarian syndrome in the nonpregnant state and luteoma of pregnancy is proposed.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[The functional state of the adrenal cortex in patients with gonadal dysgenesis and a female phenotype].

Excretion of 17-KS and 17-OCS was studied in the urine of 86 patients with various cytogenetic variants of gonad dysgenesis of a female phenotype under basic conditions and after ACTH stimulation; in 10 patients endogenous hypophyseal ACTH reserve after block of the adrenal cortex by metopyrone was investigated as well. A conclusion was drawn on the presence in these patients of differnet types of deviations of the adrenal gland function. In some of the cases there is a primary "global" or dissociated injury of the adrenal cortex, apparently directly associated with gonosome anomaly; in other cases--with disturbed regulation of ACTH secretion.

17-Hydroxycorticosteroids↗
PubMed1975

A controlled evaluation of intravenous adrenocorticotropic hormone and hydrocortisone in the treatment of acute colitis.

This study compares the efficacy of intravenous adrenocorticotropic hormone (ACTH) with intravenous hydrocortisone in the treatment of patients with symptomatic inflammatory bowel disease. Drug doses were pharmacologically equivalent on the basis of achieved plasma cortisol levels and continuously monitored urinary corticoid excretion rates. Drug selection and patient evaluation were accomplished with a random double blind technique. Evaluation of 22 consecutive hospital patients indicates that ACTH and hydrocortisone, when administered intravenously in pharmacologically equivalent dosage, are therapeutically equivalent, that response to ACTH is rapid, with no therapeutic lag, and that differences in therapeutic responses cannont be corrrelated with differences in systemic steroid levels.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Hypophyseal gonadotropin secretion in sexual precocity with McCune-Albright's syndrome].

In three young girls with isosexual precocity and fibrous dysplasia of bones, plasma gonadotropins (LH and FSH) response to releasing hormone (LH-RH) has been much under the mean response in true female precocious puberty. These data and those previously reported in the literature suggest that MacCune-Albright's syndrome correlates to an hypothalamo-pituitary dysfunction rather than to a true prematurity.

17-Hydroxycorticosteroids↗
PubMed1975

Cortisol secretion in Nelson syndrome: Persistence after "total" adrenalectomy for Cushing syndrome.

In two patients who were severely pigmented (Nelson syndrome) following bilateral adrenalectomy for Cushing syndrome, symptoms of hyper-cortisolism developed while they were receiving only physiologic steroid replacement. Cortical assays proved that endogenous cortisol production had not been obliterated. Even after total adrenalectomy, steroid measurement should be performed to guard against adrenocortical excess.

17-Hydroxycorticosteroids↗