PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “AMINO ACIDS/effects”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 73 records · Page 4Linked to original sources
PubMed1958

Latent viral infection of cells in tissue culture. VI. Role of amino acids, glutamine, and glucose in psittacosis virus propagation in L cells.

Mouse fibroblasts (L cells) fail to support the growth of psittacosis virus (6BC strain) if they are maintained on a medium containing only inorganic salts and glucose for 2 days prior to infection. Virus propagation can be stimulated by the addition of a synthetic medium containing amino acids, water-soluble vitamins, glutamine, glucose, and inorganic salts. By omitting single amino acids from the complete synthetic medium, tyrosine, threonine, methionine, isoleucine, phenylalanine, tryptophan, leucine, valine, and cysteine or cystine were found to be essential for stimulation, while lysine, arginine, histidine, hydroxyproline, proline, glutamic acid, aspartic acid, serine, alanine, and glycine were not essential. The cells on deficient media showed varying degrees of degenerative changes, but there was little correlation between ability to support psittacosis virus growth and morphologic condition of the cells. Glucose is also an essential component of the medium for viral growth, but the absence of glutamine had no effect on stimulation of virus propagation. L cell cultures maintained on media deficient in phenylalanine or tryptophan for 2 days before infection were also found to be incapable of supporting virus growth. The implications of this study in latent viral infections are discussed.

Amino Acids↗
PubMed1954

Factors related to the growth of psittacosis virus (strain 6BC). IV. Certain amino acids, vitamins, and other substances.

The analogues of amino acids, beta-2-thienylalanine, ethionine, and 6-methyltryptophane, inhibited the growth of psittacosis virus (6BC) in tissue culture without evidence of serious toxicity for the host cells. Of a number of vitamin analogues tested, only salicyl-beta-alanide inhibited viral multiplication in the absence of toxic effects on the host cells. 6,7-Diethylriboflavin, desoxypyridoxine, and oxythiamine reduced viral growth in concentrations that possessed some toxicity for host tissue. In tolerated amounts, 3-acetylpyridine, pyridine-3-sulfonic acid, pantoyl sulfanilamide, and desthiobiotin did not effect viral multiplication. Sodium malonate inhibited psittacosis virus growth in non-toxic amounts, whereas sodium monofluoroacetate was ineffective. Colchicine suppressed multiplication of virus only after a prolonged period of exposure and subsequent delay before producing inhibition, suggesting that the effect was secondary to its antimitotic action which suppressed multiplication of the host cells.

Alanine↗