PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “ANTIHISTAMINICS/effects”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 73 records · Page 4Linked to original sources
PubMed1957

Histamine release inhibition in vitro and antianaphylactic effects in vivo of some chemical compounds.

Several different types of compounds inhibited the release of histamine from the "platelet fraction" of rabbit blood when antigen was added to the blood of a sensitized rabbit in vitro. These compounds were all very toxic in vivo and could be tested only at low levels for their ability to protect animals against anaphylaxis. None of the compounds gave significant protection to sensitized animals when antigen was given intravenously. Three compounds protected animals against antigen administered as an aerosol. None of these showed any promise of clinical usefulness.Of a number of compounds which have been reported to alleviate allergic symptoms, or to protect against anaphylaxis, none prevented the release of histamine in vitro to any considerable extent.

Anaphylaxis↗
PubMed1958

Sensitization of the heart and nictitating membrane of the cat to sympathomimetic amines by antihistamine drugs.

Sensitization to the cardio-accelerator action of adrenaline and noradrenaline by five antihistamines was examined on the acutely denervated heart of the cat. Antazoline (Antistin), chlorcyclizine and promethazine (Phenergan) increased the cardio-accelerator responses to both amines equally. Mepyramine (Anthisan) increased noradrenaline more than adrenaline action. Diphenhydramine (Benadryl) resembled cocaine in potentiating the responses to noradrenaline but not to adrenaline.On the nictitating membrane mepyramine caused sensitization to the actions of adrenaline, noradrenaline and tyramine, an effect similar to that of chronic preganglionic denervation. Diphenhydramine enhanced the action of noradrenaline more than that of adrenaline and had little effect on tyramine action, giving a sensitization which bears a greater resemblance to the type caused by cocaine or chronic postganglionic denervation.It is suggested that two distinct mechanisms are required to account for the phenomena of sensitization.

Amines↗