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In-hospital resuscitation following unsuccessful prehospital advanced cardiac life support: 'heroic efforts' or an exercise in futility?

From our emergency department logbook we identified 281 consecutive patients transported to the Regional Medical Center at Memphis following failed prehospital advanced cardiac life support (ACLS). Medical records were obtained for 240 cases (85.4%). Initial cardiac rhythms in the ED included ventricular fibrillation or pulseless ventricular tachycardia (29%), electromechanical dissociation (18%), and asystole (51%). Thirty-two patients (13.3%) were successfully resuscitated in the ED, but only four (1.7%) survived to hospital discharge. Two patients had good neurologic outcomes; both degenerated to cardiac arrest shortly prior to arrival in the ED. The remaining two survivors were discharged to nursing homes with severe neurologic deficits. Of the 41 cases for whom no medical records could be found, 39 were noted in our logbook to have died in the ED. No record of subsequent hospital admission could be found for the other two. Both are presumed to have died. Failure to respond to prehospital ACLS predicts nonsurvival and may warrant cessation of efforts in the field. Future programs and research efforts in the management of out-of-hospital cardiac arrest should be focused on optimal provision of prehospital care prior to the onset of irreversible deterioration.

Emergencies↗

Does standardized mega-code training improve the quality of pre-hospital advanced cardiac life support (ACLS)?

The aim of our prospective study was to evaluate the effects of a standardized mega-code and arrhythmia training upon process elements of quality of pre-hospital advanced cardiac life support provided by a physician-staffed mobile intensive care unit. In 145 cases of adult cardiac arrest due to cardiac aetiology, time intervals from arrival of the mobile intensive care unit at the patient's side until first ECG diagnosis, first defibrillation, endotracheal intubation, and first epinephrine administration were measured with on-line tape recording, prior to, and following a standardized 8-h arrhythmia and mega-code training. Following the training, patients with asystole or pulseless electrical activity were intubated 1.1 min earlier (P = 0.03), and received epinephrine 1.3 min earlier (P = 0.01) than prior to the training. There were no significant differences in time intervals concerning management of ventricular fibrillation or tachycardia. Neither admission nor discharge rates differed significantly before and after the training. Thus, practical training including rhythm analysis and mega-code session improved the performance of our mobile intensive care unit in cases of asystole and pulseless electrical activity, and, hence, process elements of quality.

Aged↗

Combination pharmacotherapy with delayed countershock vs standard advanced cardiac life support after prolonged ventricular fibrillation.

OBJECTIVE: To test the hypothesis that combination pharmacotherapy with delayed countershock would produce higher rates of return of spontaneous circulation (ROSC) and one-hour survival when compared with standard Advanced Cardiac Life Support (ACLS) therapy. METHODS: A prospective, block-randomized, blinded, laboratory experiment was conducted in an established swine model of prolonged ventricular fibrillation (VF). Fifty-six female domestic swine were anesthetized, instrumented, and shocked into VF with a bipolar pacing catheter. The VF was untreated for 8 minutes, then basic CPR was done mechanically for 1 minute. At 9 minutes of VF, the animals were randomized to treatment with one of seven therapies: group 1, combination pharmacotherapy with epinephrine (0.20 mg/kg), lidocaine (1.0 mg/kg), bretylium (5.0 mg/kg), propranolol (1.0 mg), and U-74389G (3.0 mg/kg); group 2, epinephrine (0.20 mg/kg); group 3, lidocaine (1.0 mg/kg) and bretylium (5.0 mg/kg); group 4, propranolol (1.0 mg); group 5, U-74389G (3.0 mg/kg); group 6, normal saline solution (volume equal to that for group 1); and group 7, standard ACLS (first countershock at 9 minutes of VF). Initial countershocks for groups 1-6 were given after 11 minutes of VF. Data were analyzed with two-tailed Fisher's exact test, with alpha set at 0.05. RESULTS: Return of spontaneous circulation occurred in group 1 = 8/8 (100%); group 2 = 7/8 (88%); group 3 = 3/8 (38%); group 4 = 3/8 (38%); group 5 = 5/8 (63%); group 6 = 4/8 (50%); and group 7 = 3/8 (38%). One-hour survival occurred in group 1 = 8/8 (100%); group 2 = 5/8 (63%); group 3 = 2/8 (25%); group 4 = 2/8 (25%); group 5 = 3/8 (38%); group 6 = 2/8 (25%); and group 7 = 1/8 (13%). CONCLUSIONS: Combination pharmacotherapy with delayed countershock (group 1) produced significantly higher rates of ROSC (p = 0.03) and one-hour survival (p = 0.001) when compared with standard ACLS in this porcine model of prolonged VF.

Analysis of Variance↗

Advanced cardiac life support before and after tracheal intubation--direct measurements of quality.

STUDY HYPOTHESIS: Tracheal intubation should improve the quality of cardiopulmonary resuscitation (CPR) by enabling adequate ventilation without pauses in external chest compressions. METHODS: Out-of-hospital cardiac arrests of all causes were sampled in this non-randomized, observational study of advanced cardiac life support in three ambulance services (Akershus, London and Stockholm). Prototype defibrillators (Heartstart 4000SP, Philips Medical Systems, Andover, MA, USA and Laerdal Medical AS, Stavanger, Norway) registered all chest compressions via an extra chest pad with an accelerometer mounted over the lower part of sternum and ventilations from changes in transthoracic impedance between the standard defibrillator pads. The quality of CPR was analyzed off-line for 119 episodes. Numbers and differences are given as mean +/- S.D. and differences as mean and 95% confidence intervals. RESULTS: Chest compressions were not given in cardiac arrest for 61 +/- 20% of the time before intubation compared to 41 +/- 18% after intubation (difference: 20% (16-24%)). Compressions and ventilations per minute increased from 47 +/- 25 to 71 +/- 23 (difference: 24 (19, 29)) and 5.6 +/- 3.7 to 14 +/- 5.0 (difference: 8.7 (7.6, 9.8)) respectively. Four cases of unrecognized oesophageal intubation (3%) were suspected from the disappearance of ventilation induced changes in thoracic impedance after intubation. CONCLUSION: The quality of CPR improved after tracheal intubation, but the fraction of time without blood flow was still high and not according to international guidelines. On-line analysis of thoracic impedance might be a practicable aid to avoid unrecognized oesophageal intubation, but this area needs further research.

Advanced Cardiac Life Support↗

[Advanced cardiac life support--new answers to old dilemmas].

Sudden cardiac death is a major health hazard in the western world. During the year 2000 new guidelines for advanced cardiac life support were published. These comprehensive guidelines are based on international consensus and present the scientific evidence for each therapeutic intervention. During the following two years new studies investigating the treatment of cardiac arrest have provided new evidence for patients' care. The innovations in this area include the use of automatic external defibrillators, new drugs and measures to minimize brain injury. This review covers some of the new emerging issues in the treatment of cardiac arrest.

Brain Injuries↗

Advanced cardiac life support. Reviewing recommendations from the AHA guidelines.

Cardiovascular disease is prevalent in the older population, making older patients susceptible to complications, including cardiac arrest. Early intervention via cardiopulmonary resuscitation or another form of emergency cardiovascular care can reduce mortality in this population. In 2000, the American Heart Association, in conjunction with various international organizations, published guidelines for cardiopulmonary resuscitation and emergency cardiovascular care, which include a section on advanced cardiac life support (ACLS). By understanding these ACLS recommendations, primary care physicians will be better prepared to assist their older patients during a cardiac emergency. In the geriatric population, awareness of the patients' wishes regarding initiation of cardiopulmonary resuscitation is important in deciding if it is appropriate to proceed with these measures.

Advanced Cardiac Life Support↗

Use of the Mega Code to evaluate team leader performance during advanced cardiac life support.

The Mega Code is a simulated cardiac arrest during which students practice as members of a team and learn to integrate the knowledge and skills of advanced cardiac life support (ACLS). This study used the Mega Code and American Heart Association (AHA) standards to evaluate 32 medical residents (MDs) and nine critical care nurses (RNs) in the role of ACLS team leader. All had been previously trained in ACLS. The testing sequence included ventricular fibrillation (VF) refractory to initial countershock (defib), asystole after second defib, recurrent VF after drug therapy, and finally sinus rhythm after third defib. A blood gas report indicated respiratory acidosis and hypoxemia. Assessment of patient status was poor in both groups, although MDs did significantly (p = .001) better than RNs. Other problem areas were drug therapy and trouble-shooting are not adequately stressed in the AHA ACLS curriculum; moreover, there is no lecture that specifically addresses the team approach to resuscitation and the role of team leader. We found that the Mega Code effectively evaluated individual and group performance. Results of objective-based Mega Code testing can be used both to improve ACLS curriculum and to indicate areas to be stressed during refresher training.

Cardiology↗

Benefit of active compression-decompression cardiopulmonary resuscitation as a prehospital advanced cardiac life support. A randomized multicenter study.

BACKGROUND: We compared short-term prognosis of active compression-decompression (ACD) and standard (STD) cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrests. METHODS AND RESULTS: We randomized advanced cardiac life support (ACLS) with ACD ACLS CPR on odd days and STD ACLS CPR on even days. We measured the rates of return of spontaneous circulation (ROSC), survival at 1 hour (H1), at 24 hours (H24), and at 1 month (D30): hospital discharge (HD); neurological outcome; and complications. Mean times from collapse to basic cardiac life support CPR was 9 minutes and from collapse to ACLS CPR was 21 minutes. Compared with the STD ACLS patients (n = 258), ACD ACLS patients (n = 254) had higher survival rates (ROSC, 44.9% versus 29.8%, P = .0004; H1, 36.6% versus 24.8%, P = .003; H24, 26% versus 13.6%, P = .002; HD without neurological impairment, 5.5% versus 1.9%, P = .03) and a trend for improvement in neurological outcome at D30 (Glasgow-Pittsburgh Outcome Categories = 1.6 +/- 0.8 versus 2.3 +/- 1.1. P = .09). Sternal dislodgements (2.9% versus 0.4%, P = .03) and hemoptysis (5.4% versus 1.3%, P = .01) were more frequent in the ACD ACLS group. CONCLUSIONS: Despite long time intervals, ACD significantly improved short-term survival rates in out-of-hospital cardiac arrests compared with STD CPR.

Adult↗

Advanced cardiac life support events in a community hospital and their outcome: evaluation of actual arrests.

To evaluate resuscitation efforts for patients with cardiac and/or pulmonary arrest in our hospital a retrospective study was conducted and compared with available data from other community teaching hospitals. Records of 131 consecutive patients of ages 16-98 who received resuscitation according to Advanced Cardiac Life Support protocols were reviewed. Short-term survival (return of spontaneous circulation) and discharge-from-the hospital survival were measured. Nineteen patients (15%) were excluded from the study because the information recorded on the code record sheet was insufficient. Overall short-term survival rate was 34.8%. Resuscitations in the Emergency Room were evaluated separately, because most of them were initiated outside of the hospital. Their short-term survival was 14%, but none of them survived to be discharged. Out of 69 inpatient resuscitative efforts, 33 were successful (47.8%). Of these 33 nine (13.0%) left the hospital. The rest expired during the same hospitalization. Short-term survival for patients after coronary artery bypass graft surgery was 60% (6 of 10) and 30% (3 of 10) were discharged home. Forty percent of official code records were incomplete. We concluded that better education and more emphasis on record-keeping are mandatory, with the main burden falling upon the nurse in charge to have received more precise instruction. Contrary to published data, women did not have a better survival than men (P > 0.05). There was no difference in outcomes between resident physician directed codes compared to attending physician directed codes (P > 0.05). The mean age of inpatient short-term survivors was 69.0 (+/- 13.2) years and that of non-survivors 69.8 (+/- 15.7) years (P > 0.05). Post-bypass surgery patients had a better survival than non-surgical patients, but the difference was significant (P > 0.05). Survival in our hospital was comparable to one hospital and worse than another (34.8% vs. 39.6% or 63.0%). Despite success, prognosis after arrest remain poor.

Aged↗

Adult advanced cardiac life support: the European Resuscitation Council guidelines 1992 (abridged). European Resuscitation Council Working Party.

The European Resuscitation Council, established in 1990, is committed to saving lives by improving standards of cardiopulmonary resuscitation across Europe and coordinating the activities of interested organisations and individuals. In this regard the council has successfully brought together physicians and surgeons from eastern and western Europe and, in addition, has established relations with the American Heart Association and equivalent organisations in Canada, Australia, and South Africa. A main objective of the European Resuscitation Council is to produce guidelines for cardiopulmonary and cerebral resuscitation, and in this paper members of a working party of 14 experts from 11 countries set out an abridged version of the council's guidelines for adult advanced cardiac life support. The council hopes that the guidelines and accompanying algorithms will serve as a ready use "how to do it" for ordinary practitioners and paramedics inside and outside hospital.

Algorithms↗

Advanced cardiac life support controversy: where do antiarrhythmic agents fit in?

Approximately half of all cardiovascular fatalities are attributable to sudden cardiac death, and the majority of sudden cardiac deaths result from ventricular fibrillation (VF). Antiarrhythmic agents are needed to manage refractory VF and ventricular tachycardia (VT); the primary reason for their administration is to prevent recurrence of VF and to abolish VT. The American Heart Association recommends lidocaine hydrochloride as a first-line antiarrhythmic agent in the advanced cardiac life support (ACLS) setting, followed by bretylium tosylate. Although the newly approved intravenous antiarrhythmic agent, amiodarone hydrochloride, may potentially be effective in ACLS, studies are needed to document its clinical benefit in this setting. Such studies are currently under way to document this potential use.

Amiodarone↗

The use of antiarrhythmics in advanced cardiac life support.

Antiarrhythmic agents have been used to treat malignant ventricular arrhythmias in the setting of acute myocardial ischemia with proven efficacy for many years. Thus, it has been presumed that these agents would be efficacious for the treatment of cardiac arrest. Unfortunately, hard data supporting this contention are unavailable to date. Furthermore, some of the experimental data in this area are conflicting, especially regarding the relative effects of lidocaine and bretylium. Thus, little definitive can be said based on experimental information. In two randomized patient studies, lidocaine and bretylium performed comparably. Because of the frequent use of lidocaine and thus the familiarity of most health care professionals with its use, it makes educational sense to utilize lidocaine as the antiarrhythmic drug of first choice during the cardiac arrest sequence. Recent data suggesting that amiodarone may be efficacious in patients with recurrent arrhythmias require additional confirmation. Although antiarrhythmic agents have been shown to be effective in the treatment of malignant arrhythmias in patients with acute myocardial infarction, their use prophylactically for patients with suspected infarction (advocated in the past) has recently undergone reevaluation. It is now clear that despite a reduction in ventricular fibrillation, overall mortality may be increased. This may be because the prophylactic treatment of patients with suspected infarction includes a large number of patients not at risk for ventricular fibrillation who still may be at risk for drug toxicity. Thus, prophylactic administration of lidocaine to all patients with suspected acute myocardial infarction can no longer be recommended. There are inadequate data upon which to base a recommendation concerning the use of lidocaine in patients receiving thrombolytic therapy. The group most likely to benefit from lidocaine are patients with ST segment elevation who present early after the onset of acute myocardial infarction. The use of lidocaine in this group requires additional study. At present, despite enthusiasm for the prophylactic use of magnesium for the treatment of arrhythmias, data are inadequate to support its routine administration. However, given the importance of magnesium and potassium levels in the genesis of malignant arrhythmias, their levels in plasma should be assessed, and abnormalities should be promptly corrected. The potential uses of antiarrhythmic agents during advanced cardiac life support span a remarkably diverse number of applications. For the purpose of this review, only the use of these agents during CPR and during the early hours of acute or suspected acute myocardial infarction will be considered.

Anti-Arrhythmia Agents↗

Advanced cardiac life support: update on recent guidelines and a look at the future.

The objectives of this article are to provide an update of the American Heart Association (AHA) 1992 National Conference guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiac care and to review the investigation and development of new methods of CPR which may be considered in future recommendations. Despite an organized approach to sudden cardiac arrest, survival in patients receiving CPR is in the range of 5-15%. The new AHA guidelines recommend standard manual CPR performed at a rate of 80-100 compressions/min and organized algorithms of advanced cardiac life support. These guidelines stress widespread community training and rapid response in the following sequence: (1) recognition of early warning signs, (2) activation of the emergency medical system (EMS), (3) basic CPR, (4) early defibrillation, (5) intubation, and (6) intravenous medication. Several new recommendations pertain specifically to in-hospital care and are, therefore, particularly relevant to physician management of cardiac arrest. The best predictor of survival in patients requiring circulatory support after cardiac arrest is attainable coronary and cerebral perfusion. Unfortunately, the minimal levels of end-organ perfusion required to sustain life are often difficult or impossible to achieve with standard manual cardiopulmonary resuscitation and several new techniques have therefore been introduced. The most promising of these techniques are (1) interposed abdominal compression, (2) pneumatic vest, and (3) active compression-decompression resuscitation. Each of these techniques offers unique advantages when compared with standard manual cardiopulmonary resuscitation. The 1992 National Conference recommendations provide a rational framework for the resuscitation of cardiac arrest victims. New methods of cardiopulmonary resuscitation are now available and investigation into these methods continues.(ABSTRACT TRUNCATED AT 250 WORDS)

Algorithms↗

Education and evaluation in emergency cardiac care programs (CPR and advanced cardiac life support): state of the art.

To increase the survival rate for out-of-hospital cardiac arrest, improvements in training must be made so that lay rescuers are motivated and have the ability to get involved. To overcome some of the fear and lack of involvement, better education strategies are needed. Adults learn didactic information through understanding and skills through repetition and reinforcement. Due to the fact that there is limited time that adults will commit to learning CPR, methods of simplification of the techniques need to be used so that there can be sufficient repetition and reinforcement. Teaching two-rescuer CPR to lay rescuers should not routinely be done. Most adults, particularly those around high-risk individuals, should learn one-rescuer CPR. Infant resuscitation should be taught predominantly to those around small children. Methods of reinforcement through the mass media should be attempted on a routine basis. Whenever possible the courses should be spread over a period of time to allow for repetition and reinforcement, thereby maximizing learning. Advanced cardiac life support (ACLS) should be widely taught to health professionals. ACLS instruction needs to be spread over time, whenever logistically possible, to enhance learning and retention. Good, validated examinations are needed and should be routinely rotated. Better methods of evaluation are needed to look at the benefit of these types of programs and to improve the cost-benefit ratio.

Educational Measurement↗

[Advanced cardiac life support in the prehospital setting in the Reykjavik area 1991-1996.].

UNLABELLED: Since 1982 an emergency ambulance manned by a physician and two emergency medical technicians has been operated in the Reykjavik area. The physicians have followed guidelines from the American Heart Association (AHA). Until 1986 the AHA guidelines had bicarbonate and in some instances calcium as first line treatment in cardiopulmonary resuscitation (CPR). OBJECTIVE: The purpose of this study was to evaluate the influence of the advanced cardiac life-support (ACLS) service and of bystanders on survival after cardiopulmonary arrest. Also to compare the survival rates to results of previous studies of CPR outside the hospital in the Reykjavik area. MATERIAL AND METHODS: The data was collected prospectively according to the "Utstein Style" form. From 1991-1996 there were 361 attempted resuscitations by the emergency crew. Fifty-three cardiac arrests were secondary to trauma, suicide, drowning, drug overdose and sudden infantile death. In 308 cases of sudden cardiorespiratory arrest cardiac diseases were the presumed cause in accordance with the Utstein protocol. RESULTS: In the 308 cases the mean age was 67.2 years and the male/female ratio was 233:75. The mean response time was 4.6 min. Patients admitted to the intensive or cardiac care units were 98 (31%) and 51 (17%) were discharged from the hospital. Ventricular fibrillation or ventricular tachycardia were the most common initial rhythms seen in 176 (57%) patients, asystole in 91 (30%) and other arrhythmias (EMD, agonal) in 41 (13%). Fourty-six patients (26%) with ventricular fibrillation on the first rhythm strip survived to be discharged from the hospital, three (3%) patients with asystole and two (5%) with other arrhythmias. Bystanders were present in 211 (68%) of cases and it fourfoulded the likelihood of discharge (OR 4.0; 95% CI 1.5-10.4; p=0.0025). There is no statistical difference in mean response time and survival rates between this study and previous studies from 1982-1986 and 1987-1990. CONCLUSIONS: When sudden cardiorespiratory arrest is witnessed the probability of survival is multiplied. We conclude that the results of ACLS outside the hospital in Reykjavik and surrounding area continue to be among the best. Changes in ACLS guidelines do not appear to have increased survival.

English Abstract↗

Advanced cardiac life support in the prehospital setting: the Reykjavik experience.

Since 1982 a mobile emergency care unit (emergency ambulance) manned by a physician has been operated in Reykjavik. During 1982-1986 there were 138 attempted resuscitations in sudden cardiorespiratory arrest from cardiac causes. Twenty-four patients (17%) were discharged home, all but one without mental impairment. Seventy-three patients presented with ventricular fibrillation, 21 (29%) of which were discharged. The mean ambulance response time was 5 min. Bystanders initiated cardiopulmonary resuscitation (CPR) in 40 cases (29%) which significantly improved the outcome. In witnessed arrests, 19 of 36 patients (53%) with bystander-initiated CPR were discharged compared to 5 of 62 patients (8%) where CPR awaited the arrival of the ambulance team. These results are comparable to those obtained in larger metropolitan areas. In small urban areas the size of Reykjavik (population of 110,000), an advanced and efficient prehospital care can be organized as an extension of the emergency departments role.

Adult↗