[Application of lasers in biometry and diagnosis].
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The leading principles of biometrical design, evaluation and decision making in biomedicine can be summarized as follows: (1) formulation of the problem to be solved and of the specific question(s) to be answered; (2) definition of the population in study, ways of sampling and manoeuvres (treatments); (3) determining the kind and number of variables (time intervals of measurement, investigated biomedical parameters); (4) performing the pilot study if necessary (to arrange randomized blocks, to form hypotheses); (5) formulation of zero (alternative) hypothesis, setting the values of alpha(beta) risk; (6) ordering the sample sizes; (7) testing the type of statistical distribution and the homoscedasticity of the obtained data; (8) calculation of the point and interval (confidence, tolerance) estimates; (9) performing the chosen tests, e.g. on the significance of differences or correlations; and (10) the conclusions for science and practice, with eventual return to point (1) on a higher level of knowledge.
The basic biometric theories for different types of clinical studies in Oto-Rhino-Laryngology are presented with a minimum use of formulae. A check-list is sketched with all points to be taken into account in the design of a study. The prerequisites for organisation of work and data processing are outlined. The understanding of this methodological basis can be very helpful in promoting the collaboration of clinicians and statisticians in pursuing successful clinical investigations in the field of Oto-Rhino-Laryngology.
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One hundred hearts of baboons were studied (P. hamadryas and P. cynocepahlus). The weight and the volume of the hearts were measured by Scherle method (1970). The other measurements were: oblique diameter right "atrium" - apex cordis", right and left free ventricular thickness and the inner aorta diameter. The hearts were also studied by gross dissection and anatomical sections. The morphology of the heart of the baboon proved to be similar to the human heart morphology. Probably it is a good model to the cardiovascular research and may be surgical applications.
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A simple instrument has been developed for measurement of axial length and anterior chamber depth. It is pocket sized, and the digital output is easy to interpret. The long term accuracy of 0.2 mm is ideal in helping to eliminate errors of lens selection.
Modern stereotactic surgical procedures were developed mainly because digital CT image gave us the opportunity to recognize the morphology and the site of a brain lesion, and, at the same time, CT offered a very easy and reliable way to calculate target coordinates because the brain scans are digital maps. Digital x-ray image obtained with an x-ray-intensifier and a TV Analog/Digital converter is not suitable for stereotactic use because image distortion is multifactorial and it is impossible to rectify. We have developed a new apparatus (Neurogil) for intra-operative use that is able to produce a digital image on a display, the measures displayed match exactly with the patient's brain. A linear array of 1024 photodiodes is working in front of an x-ray source and it collects the density image of the patient's head positioned between them. It shows the patient's head with the stereotactic frame exactly as a radiogram, but no distortion is present. Digital brain angiograms are possible with electronic subtraction, mathematical enhancement and with a stereoscopic view on a particular display. Any kind of mathematical calculation or computer-graphic application is possible. A special software was developed for stereotactic closed and open surgery.