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Results for “CARBON DIOXIDE/effects”

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At least 73 records · Page 4Linked to original sources
PubMed1957

The effect of inhalation of 30% carbon dioxide on the peripheral circulation of the human subject.

Inhalation of 30% carbon dioxide for 1 to 2 min. caused a transient increase followed by a marked fall in blood flow through the normal forearm and calf. Since there was an associated large increase in arterial blood pressure, the fall in flow was due to intense vasoconstriction. It is likely that the vasoconstriction in the forearm occurred deep to the skin because the oxygen saturation of the superficial venous blood did not fall during the inhalation. Since there was a slight decrease in flow through the nerve-blocked forearm in spite of the increased blood pressure, it is unlikely that nervous vasoconstriction can completely account for the marked decrease in muscle flow.

Blood Circulation↗
PubMed1957

The effects of mecamylamine in the cat as modified by the administration of carbon dioxide.

A series of cats, anaesthetized with chloralose, was given intravenously a sufficient quantity of mecamylamine to produce hypotension and a 50% neuromuscular block. Inhalation of carbon dioxide then produced a further depression of blood pressure and an increase in the neuromuscular blocking effect. It was shown that, following the administration of carbon dioxide, the plasma mecamylamine levels increased coincident with the increased pharmacological effects.

Animals↗
PubMed1959

The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin.

Carbonic acid inhibited the stimulating action of histamine on guinea-pig intestine and of oxytocin on the uterus of many animal species. This effect was relatively specific. Under the same conditions the actions of acetylcholine, KCl, adrenaline (on rabbit uterus), and ergot alkaloids were not inhibited. The electrical excitability of smooth muscle was similarly not affected. The inhibitory action of carbonic acid is directly proportional to its concentration in the medium in which the isolated organ is maintained. The study of the activity of histamine and oxytocin at different pH in a medium free of NaHCO(3) and buffered with a mixture of sodium maleate and maleic acid suggested that the inhibitory action exerted by carbonic acid was specific and independent of the simultaneous modifications of the hydrogen ion concentration. The mechanism of these phenomena is discussed.

Acetylcholine↗