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At least 73 records · Page 4Linked to original sources
PubMed1996

[Evaluation of the effectiveness of screening for tumors of the digestive system].

Some features of digestive cancers encourage screening programs, even though no such program has been shown so far effective in reducing mortality rates. The visual inspection of the oral cavity and pharynx, with the addition of flexible endoscopy and, possibly, blue-toluidine staining, can be easily performed by specialists and dentists. The strong association with smoking habits and alcohol consumption favours the organization of screening programs but primary prevention maintains the highest priority. For cancer of the colon-rectum two different screening approaches are under close scrutiny: fecal occult blood testing, on an yearly basis, and once-in-a-life sigmoidoscopy at 55-60 years of age. Only one of five ongoing randomized prospective studies on occult blood testing has reported, so far, a significant reduction, around 33%, of mortality from colorectal cancer, with, however, a large burden of sigmoidoscopies.

Colorectal Neoplasms↗
PubMed2004

Anaerobic sewage treatment in a one-stage UASB reactor and a combined UASB-Digester system.

The treatment of sewage at 15 degrees C was investigated in a one-stage upflow anaerobic sludge blanket (UASB) reactor and a UASB-Digester system. The latter consists of a UASB reactor complemented with a digester for mutual sewage treatment and sludge stabilisation. The UASB reactor was operated at a hydraulic retention time of 6h and a controlled temperature of 15 degrees C, the average sewage temperature during wintertime of some Middle East countries. The digester was operated at 35 degrees C. The UASB-Digester system provided significantly (significance level 5%) higher COD removal efficiencies than the one-stage UASB reactor. The achieved removal efficiencies in the UASB-Digester system and the one-stage UASB reactor for total, suspended, colloidal and dissolved COD were 66%, 87%, 44% and 30%, and 44%, 73%, 3% and 5% for both systems, respectively. The stability values of the wasted sludge from the one-stage UASB reactor and the UASB-Digester system were, respectively, 0.47 and 0.36g CH(4)-COD/g COD. Therefore, the anaerobic sewage treatment at low temperature in a UASB-Digester system is promising.

Bacteria, Anaerobic↗
PubMed1965

Specific carcinoembryonic antigens of the human digestive system.

A wide variety of human adult and fetal tissues were studied by immune-diffusion techniques in agar gel to determine whether they contained the tumor-specific antigen(s) previously found in coionic cancers. In the adult tissues it was demonstrated that identical antigens were present in all tested specimens of malignant tumors of the entodermally derived epithelium of the gastrointestinal tract and pancreas, but were absent from all other tested adult tissues. The common antigenic constituents, therefore, represent system-specific cancer antigens of the human digestive system. System-specific cancer antigens have not previously been demonstrated in humans. Experiments with fetal tissues demonstrated that identical antigens were also present in fetal gut, liver, and pancreas between 2 and 6 months of gestation. These components were named "carcinoembryonic" antigens of the human digestive system. On the basis of the present findings and the recent work regarding control of the expression of genetic potentialities in various types of cells, it was concluded that the carcinoembryonic antigens represent cellular constituents which are repressed during the course of differentiation of the normal digestive system epithelium and reappear in the corresponding malignant cells by a process of derepressive-dedifferentiation.

Antigens↗
PubMed1968

Physicochemical studies of the carcinoembryonic antigens of the human digestive system.

A procedure has been described for the purification of the carcinoembryonic antigens (CEA) of the human digestive system. Tumor tissue extraction in 0.6 M perchloric acid followed by paper block electrophoresis and column chromatography on Sephadex G-200 resulted in highly purified CEA preparations as determined by both immunological and physicochemical criteria. The properties and composition of five different purified CEA preparations derived from digestive system cancer metastases were examined. The findings demonstrated a high degree of uniformity amongst these samples. Sedimentation coefficients ranged from 6.9 to 8S. Each sample showed the presence of 14 different amino acid residues and six different carbohydrate constituents (four of which could be quantitated with the amount of material available for analyis). Studies of a purified CEA preparation from a primary hepatoma yielded results which, in some respects, differed from those obtained with the CEA samples of metastatic tumor origin. The implications of these variations were discussed with regard to the probable presence of non-CEA components in the hepatoma preparation. Of primary importance was the observation that the few normal adult digestive system tissues tested failed to show the presence of constituents similar to the CEA. This finding would seem to indicate that, in the adult, the carcinoembryonic antigens of the human digestive system are qualitatively tumor-specific and are not dectectable in comparable normal tissues.

Amino Acids↗
PubMedDate not supplied

The digestive system: linking theory and practice.

This article, the second in the nutrition series, presents an outline of food chemistry and the digestion of energy-producing foods. It is hoped that this will facilitate understanding of some of the principles of nutrition. A number of 'clinical points' are highlighted to emphasize the link between theory and practice. The processes by which the chemical building blocks (carbon, oxygen, hydrogen and nitrogen) are formed into more complex molecules such as proteins, carbohydrates and fats are explained. The gross anatomy of the digestive system is outlined and the sites where digestive enzymes are secreted are identified. Regulation of the digestive system by endocrine secretions and the nervous system is described and tabulated.

Carbohydrate Metabolism↗
PubMed2005

[Study on the long-time effect on allitridum and selenium in prevention of digestive system cancers].

OBJECTIVE: To evaluate the long-time effect on allitridum and selenium in preventing cancer of digestive system. METHODS: Persons who were recruited into the intervention group and took allitridum and selenium to prevent gastric cancer in Qixia county of China from 1989-1991 were followed up to 2001 and data of deaths was collected. The long effect on allitridum and selenium in preventing cancer of digestive system was analysed. RESULTS: Data were compared to placebo group five years (1992-1996) after the termination of intervention to have found that the accumulative mortality rate of all cancer, digestive system cancer and gastric cancer had decreased 45.5%, 41.2% and 63.3% in the intervention group respectively. By stratum analysis, accumulative mortality rate of all cancer, digestive system cancer and gastric cancer had decreased 51.5%, 51.5% and 67.7% in males of the intervention group, respectively. Relative risks for males in the intervention group were 0.48, 0.47 and 0.30 times more than the placebo group, respectively. All of them were statistically significant. Relative risks for females in the intervention group were 0.74, 0.92 and 0.70 times more than placebo group. Six to ten years later after the termination of intervention, the accumulative mortality rate and relative risk of all cancers in two groups became similar. CONCLUSION: Allitridum and selenium had the effect of decreasing the incidence risk of digestive cancer with a protective rate more than 50% for five years after the termination of intervention program.

Adult↗
PubMed2004

Aquaporins in the digestive system.

Fluid transfer such as secretion and absorption is one of the major functions of the digestive system. Aquaporins are water channel proteins providing water transfer across the cellular membrane. At least six aquaporin isoforms are expressed in the digestive system. Aquaporin-1 (AQP1) is widely distributed in endothelial cells of capillaries and small vessels as well as in the central lacteals in the small intestine. AQP1 is also present in the duct system in the pancreas, liver, and bile duct. AQP3 is mainly expressed in the epithelia of the upper digestive tract from the oral cavity to the stomach and of the lower digestive tract from the distal colon to the anus. AQP4 is present in the parietal cells of the stomach and in the intestinal epithelia. AQP5 is expressed in acinar cells of the salivary, pyloric, and duodenal glands. AQP8 is expressed in the intestinal epithelia, salivary glands, pancreas, and liver. AQP9 is present in the liver and intestinal goblet cells. Aquaporins have important roles in the digestive system, such as AQP5 in saliva secretion, as shown by the studies on AQP5-null mice. In addition, water transfer across the digestive epithelia seems to occur not only via aquaporins but also via other transporter or channel systems.

Animals↗
PubMedDate not supplied

[A comparative evaluation of the action of kvamatel and omez on the glutathione system in different sections of the digestive system in experimental duodenal ulcer].

Experiments on male albino rats demonstrated significant changes in the content of oxidized and reduced glutathione in the tissues of the liver, pancreas, stomach, duodenum, and small intestine in acetate ulcer of the duodenum. Experimental therapy with quamatel and particularly with omez led to activation of the glutathione system in the tissues under and in this way increased their resistance to the ulcerogenic effect.

Animals↗
PubMed1996

[Analysis of mortality by population groups migrating within the country. Tumors of the digestive system].

This paper analyzes mortality of digestive system cancers in Italy during the years 1981-84 by groups of people migrated inside the country. Individuals born and died in the same region are defined as "stables". "Migrants" indicate individuals for which the region of birth differ from that of residence. Mortality for cancers of oral cavity and pharynx, and of the oesophagus, shows a negative effect of being born in the high risk regions of the north-east and a protective effect of being born in the low mortality regions of the south. Leaving high risk areas brings a positive effect, while to settle there makes mortality getting worse. For stomach cancer, the birth effect is very strong: in this first generation of migrants mortality rates are very similar to those of the stable in the birth areas. A strong migration effect is observed for colorectal cancer mortality: age specific mortality rates in migrants fit well those of host stable population. Liver cancer mortality of migrants from high risk areas approaches the one of the host population. Pancreatic cancer mortality shows a protective effect of being born in the south and a negative effect of residing in the northern high mortality areas.

Adolescent↗
PubMed2005

Clinical analysis of multiple primary malignancies in the digestive system: a hospital-based study.

AIM: To analyze the characteristics of multiple primary malignancies (MPMs) of digestive system; including incidence, types of tumor combinations, time intervals between development of multiple tumors, clinical course, and prognostic factors affecting survival and mortality. METHODS: Data from a total of 129 patients treated from January 1991 to December 2000 for pathologically proved MPMs, including at least one originating from the digestive system, were reviewed retrospectively. RESULTS: Among 129 patients, 120 (93.02%) had two primary cancers and 9 (6.98%) had three primary cancers. The major sites of MPMs of the digestive system were large intestine, stomach, and liver. Associated non-digestive cancers included 40 cases of gynecological cancers, of which 31 were carcinoma of cervix and 10 cases of genitourinary cancers, of which 5 were bladder cancers. Other cancers originated from the lung, breast, nasopharynx, larynx, thyroid, brain, muscle, and skin. Reproductive tract cancers, especially cervical, ovarian, bladder, and prostate cancers were the most commonly associated non-GI cancers, followed by cancer of the lung and breasts. Forty-three cases were synchronous, while the rest (86 cases) were metachronous cancers. Staging of MPMs and treatment regimes correlated with the prognosis between survival and non-survival groups. CONCLUSION: As advances in cancer therapy bring about a progressively larger percentage of long-term survivors, the proportion of patients with subsequent primary lesions will increase. Early diagnosis of these lesions, based on an awareness of the possibility of second and third cancers, and multidisciplinary treatment strategies will substantially increase the survival of these patients.

Adult↗
PubMed1995

Early transition of the digestive system to exogenous nutrition in domestic post-hatch birds.

The effect of early transition of the digestive system to exogenous nutrition was examined in three experiments with growing birds. A nutrient mixture (0.5 ml) of glucose, starch and oil (1:1:0.5, by vol) was orally administered immediately after hatch to turkey poults (Meleagris gallopavo) having immediate or delayed access to feed (Expt 1). Increasing amounts (0, 0.25 and 0.5 ml) of this mixture were administered immediately after hatch to turkey poults (Expt 2), or to broiler chicks (Gallus domesticus; Expt 3). The relative weights of the gastrointestinal tract (GIT) and its ingesta content, and the amylolytic capability of the pancreas were examined during the immediate post-hatch period (to 30 h). Oral administration of nutrients immediately after hatching only slightly influenced the growth of the pancreas and its amylolytic activity, but significantly increased GIT weight in both species, in a dose-dependent manner. It is suggested that early post-hatching exposure of the digestive system by the forced administration of nutrient mixture induces anatomical and metabolic changes in the digestive system slightly earlier than in birds with late access to feed. This increases GIT content and plasma glucose levels, resulting in enhanced feed consumption and growth promotion.

Animals↗
PubMed1985

Determination and significance of a new carbohydrate antigen CA19-9 in digestive system cancers.

To assess the diagnostic significance of CA19-9, the serum levels in 225 healthy subjects, 201 patients with cancers, 423 patients with benign diseases and 21 pregnant women, were determined by RIA. The mean CA19-9 level of the healthy subjects was 11.2 +/- 0.4 U/ml (range, 6-100 U/ml). Only 3.1% of them were above 37 U/ml. The CA19-9 levels were elevated above 37 U/ml in 7.9% of 293 patients with non-carcinomatous diseases of the digestive system. Among digestive system cancers, elevated levels were found in 18.2% of 11 patients with esophageal cancer, 42.7% of 68 patients with gastric cancer, 39.1% of 23 patients with colorectal cancer, 27.8% of 18 patients with primary hepatic cancer, 71.4% of 35 patients with biliary cancer, and 75% of 20 patients with pancreatic cancer. Most of the patients with levels above 100 U/ml had carcinomatous diseases. The CA19-9 positive rates for patients with gastric cancer and colorectal cancer were extremely low at stages I, II and III, while in patients at stage IV and in patients with recurrent cancer, a tendency for rapid increase in the positive rates and concentrations of CA19-9 was noted. Based on combination assay of CA19-9, CEA and ferritin, in comparison with the positive rates for CA19-9 alone, it was found that the rates were raised to 42.7% in gastric cancer, to 39.1% in colorectal cancer, and to 71.4% in biliary cancer, suggesting the simultaneous determination with these tumor markers may serve to elevate their usefulness.

Adolescent↗