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Cerebral dominance and asynchrony between bimanual two-dimensional movements.

The asynchrony of bimanual movements was investigated. Right- and left-handers traced simple geometrical patterns (ellipses) continuously with both hands. All combinations of the direction of rotation in each hand were executed at different rhythms. Geometrically, performances were largely independent of manual dominance. However, by comparing the passage times at homologous positions, the authors found that the dominant hand led the nondominant one by about 25 ms. The asynchrony was affected by neither movement type nor rhythm. The variability of the asynchrony varied along the trajectory, with well-defined maxima and minima. The variability profiles for movements that engaged homologous muscles differed markedly from those that engaged nonhomologous muscles. The authors discuss the hypothesis that bimanual periodic movements are timed by a lateralized functional module and asynchrony is due to the necessity of transmitting time-keeping information to the other hemisphere.

Adult↗

Hypothalamic digoxin, regulation of neuronal transmission, and cerebral dominance.

The present study assessed the neurochemical differences between right hemispheric dominant and left hemispheric dominant individuals. The HMG CoA reductase activity, serum digoxin, magnesium, tryptophan catabolites, tyrosine catabolites, and RBC membrane (Na+)-K+ ATPase activity were measured in individuals of differing hemispheric dominance. The results showed that right hemispheric dominant individuals had elevated digoxin synthesis, increased tryptophan catabolites, and reduced tyrosine catabolites and membrane (Na+)-K+ ATPase with hypomagnesemia. Left hemispheric dominant individuals had the opposite patterns. Right hemispheric dominance represents a hyperdigoxinemic state with membrane sodium-potassium ATPase inhibition. Left hemispheric dominance represents the reverse pattern with hypodigoxinemia and membrane sodium-potassium ATPase stimulation.

Adult↗

Hypothalmic digoxin, cerebral dominance, and sexual orientation.

The human hypothalamus produces an endogenous membrane Na(+)-K(+) ATPase inhibitor, digoxin. Membrane Na(+)-K(+) ATPase inhibition leads to increase in intracellular calcium and upregulated nitric oxide synthesis. In homosexuals, promiscuous heterosexuals, and bisexuals there was increased digoxin synthesis, reduced membrane Na(+)-K(+) ATPase activity, increased nitric oxide levels, increased tryptophan catabolites, and reduced tyrosine catabolites. This pattern correlated with that obtained in right hemispheric chemical dominance. In nonpromiscuous heterosexuals and left hemispheric chemical dominance there was hypodigoxinemia and the reverse biochemical patterns. Hemispheric dominance and hypothalamic digoxin could regulate sexual orientation. This has to be viewed in the setting of hyperdigoxinemia reported in acquired immunodeficiency syndrome.

Adult↗

Sign language aphasia following right hemisphere damage in a left-hander: a case of reversed cerebral dominance in a deaf signer?

Recent lesion studies have shown that left hemisphere lesions often give rise to frank sign language aphasias in deaf signers, whereas right hemisphere lesions do not, suggesting similar patterns of hemispheric asymmetry for signed and spoken language. We present here a case of a left-handed, deaf, life-long signer who became aphasic after a right-hemisphere lesion. The subject exhibits deficits in sign language comprehension and production typically associated with left hemisphere damaged signers. He also exhibits evidence of local versus global deficits similar to left-hemisphere lesioned hearing patients. This case represents reversed lateralization for sign language and also may represent reversed lateralization for visuo-spatial abilities in a deaf signer.

Aphasia↗

Normal-mirrored letter recognition, same-different judgment and cerebral dominance.

Either normal or mirror images of Kana, Kanji and capital letters were presented tachistoscopically in a left or right visual field, and then normal letters were flashed simultaneously at the fixation point. Subjects were trained to give same (formula: see text) or different (formula: see text) judgments to pairs of stimuli. Reaction time (RT) and percentage of errors (PE) were measured. Generally, normal letters with same judgments revealed a right field advantage, while with different judgments, there were not significant laterality differences. In the case of mirrored letters, each of two judgments showed no lateral asymmetries for each kind of letters excepting a left field advantage for mirrored Kana words with different judgments. PE methods tended to produce a right field advantage more consistently than did RT methods.

Adult↗