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[The concentration of potassium in the blood and 2,3-diphosphoglyceric acid in the erythrocytes during surgery of the abdominal aorta accompanied by massive blood loss].

It has been demonstrated that transfusions of large amounts of stabilized donor blood and prolonged ischemia due to clamping of the abdominal aorta during surgery were not accompanied by an increase in K+ plasma level thanks to therapy aimed at the correction of hypovolemia and hemodynamic stabilization. A decrease in K+ plasma level directly depended on the volume of the liquid transfused, the degree of hemodilution and to some extent on 2,3-DPG level. There was a drop in 2,3-DPG level intraoperatively, which was due to the use of stored donor blood for blood loss compensation and to mounting metabolic acidosis (lactate acidosis included) and gaseous acidosis.

Adult↗
PubMed1984

Binding characteristics of a fluorescent analogue of diphosphoglyceric acid to human, amphibian and fish hemoglobins.

An attempt was made to establish the binding of N-(2,4-diphosphobenzyl)-1-amino-5-naphthalenesulfonic acid, DIPANS, as an estimator of conformation in the carbonmonoxy (CO)-hemoglobins (Hbs) of several vertebrates. DIPANS failed to bind menhaden I, trout I or tuna Hbs which are ligand insensitive. Below a pH of 7.0, DIPANS bound menhaden II, Bufo, Xenopus, and human Hbs with a binding stoichiometry greater than one. The charge of the DIPANS molecule does not control its binding to these Hbs. The binding to human CO-Hb can not be due to Hb conformation. For Xenopus Hbs and menhaden II, conformation predominates DIPANS binding. The binding to CO-Hb of DIPANS, can not be unambiguously attributed to the Hb's quaternary conformation.

Animals↗