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PubMed2001

[Changes in the endocrine system in the course of sulpiride therapy].

The influence of sulpiride, a neuroleptic included into the group of benzamide derivatives, upon endocrine system has been discussed in the article. It is noted that sulpiride clearly increases the evolution of prolactin in both sexes. It gives a chain of various consequences. They are, among others, impairment of gonad activity in both sexes which causes emmeniopathy and galactorrhea in women and impotence in men. The influence of hyperprolactinemia, caused by sulpiride, upon the level of testosterone in plasma and also upon the evolution of progesterone has been also discussed. The knowledge of the influence of sulpiride upon endocrine system is necessary for physicians applying therapy by this medicine. In the article the analysis has been carried out how wider and wider used neuroleptic-sulpiride--influences upon endocrine system and particularly upon the evaluation of prolactin. In the article the main methods of action of the known neuroleptic-sulpiride have been discussed. This is an antiautistic, activizing, antipsychotic and antidepressive action. The other authors used sulpiride in therapy of depressive endogenic syndrome. They obtained a good therapeutic effect. The drug distribution in human organism was also taken into consideration. The mechanism of action of sulpiride and its extrapsychiatric application was also mentioned. The other authors often combines the drug with benzodiazepine derivatives which soothe the fear characteristic of depression.

Antidepressive Agents, Second-Generation↗
PubMed1994

Recent advances in endothelin research on cardiovascular and endocrine systems.

Recent advances in ET research on the cardiovascular and endocrine systems were reviewed. Considering the potent vasculotropic actions, strategically advantageous localization, and recent findings with the specific receptor antagonist, ET is potentially involved in the regulation of hemodynamic homeostasis and in the pathogenesis of essential and secondary hypertension. The mitogenic action on the vascular smooth muscle cells suggests its more chronic effect on the vascular structure. In addition to the hypertensinogenic aspects, the role of ET in maintaining blood pressure in a hypotensive condition should not be overlooked. The development of specific antagonists which block the action of locally operating ET in vivo will be a powerful tool in elucidating the pathophysiological significance of ET and will provide a new therapeutic approach for hypertension. The roles of ET in the endocrine system are also fascinating. Accumulating evidence supports the notion that ET modulates the secretion of pituitary and adrenal hormones. The mode of action is likely to be paracrine/autocrine rather than endocrine, although a possible role of circulating ET cannot be ruled out. The pathophysiological role of ET in the endocrine tissues remains to be clarified. The diversity of the action of ET on the blood pressure and endocrine functions provides further evidence of the complexity of the homeostatic mechanisms, leaving us an intriguing subject for future study.

Adrenal Glands↗
PubMed2003

The response of endocrine system to stress loads during space flight in human subject.

The responses of endocrine system to the exposure to stress-work load and hormonal changes during oral glucose tolerance tests were studied in the Slovak astronaut before (three weeks before flight), during (on the 4th and the 6th days of space flight), and after space flight (1-3 days and 15-17 days after space flight) on board of space station MIR. Blood samples during the tests were collected via cannula inserted into cubital vein, centrifuged in the special appliance Plasma-03, frozen in Kryogem-03, and at the end of the 8-day space flight transferred to Earth in special container for hormonal analysis. Preflight workload produced an increase of plasma norepinephrine and a moderate elevation of epinephrine levels. Plasma levels of insulin, growth hormone, prolactin and cortisol were not markedly changed immediately or 10 min after the end of work load. The higher increases of plasma growth hormone, prolactin and catecholamine levels were noted after workload during space flight as compared to preflight response. The higher plasma glucose and insulin levels were noted during the oral glucose tolerance test in space flight and also in the post flight period. Plasma epinephrine levels were slightly decreasing during glucose tolerance test; however, plasma norepinephrine levels were not changed. The similar patterns of catecholamine levels during glucose tolerance test were found when compared the preflight, in-flight and post flight values. These data demonstrate the changes of the dynamic responses of endocrine system to stress-work and metabolic loads during space flight in human subject.

Adaptation, Physiological↗
PubMed1977

Some phylogenetical aspects on the occurrence of somatostatin in the gastro-entero pancreatic endocrine system. A histological and immunocytochemical study, combined with quantitative radioimmunological assays of tissue extracts.

Rodioimmunoassayable somatostatin (SRIF) was found in acid ethanol extracts from various parts of the gastro-entero-pancreatic (GEP) endocrine system in reptiles, amphibians, teleost bony fish, cartilaginous fish, and jawless fish, as well as in a deuterostomian invertebrate, the tunicate, Ciona intestinalis. The cellular sites could, as a rule, be easily visualized light-microscopically by the peroxidase-anti-peroxidase (PAP) immunocytochemical procedure, using guinea-pig and rabbit antisera against synthetic SRIF. The standard Hellerström-Hellman technique, used to detect argyrophi SRIF-storing D cells, failed to visualize the SRIF cells in teh GEP endocrine system of the tumicate and of the jaw-less fish. Moreover, the results comfirmed the previous description that this technique only exceptionally (and sometimes only after further modifications) gave positive results when applied to the GEP endocrine system of bony fish, amphibians, and reptiles. In cartilaginous fish, however, it worked adequately and confirmed the radio-immunological and immunocytochemical observations. In the mucosa of the alimentary tract and in the parenchyma of its associated glands of one echinoderm and two pelecypod molluscs and one crustacean arthropod no sgns of the occurrence of SRIF-storing cells were observed using the three correlated procedures. In several of these tissues, signs of the occurrence of insulin-producing cells had perviously been observed. Thus, SRIF seems to appear at a later evolutionary stage than insulin. The principal islets (Brockmann corpusles) of the marine teleost fish, Cottus scorpius, had the highest concentrations of radioimmunoassayable SRIF of all the GEP organs and tissues investigated, viz. about 200 ng/mg wet weight. Nevertheless, it was only 1/5 of the actual insulin content.

Animals↗
PubMed1980

The control of calcium and phosphorus metabolism by the vitamin D endocrine system.

Vitamin D, which is normally produced in the skin under ultraviolet irradiation, is the building block for a new endocrine system that involves hydroxylation on the 25-position in the liver followed by 1 alpha-hydroxylation in the kidney to produce the vitamin D hormone, 1 alpha, 25-(OH)2D3. This vitamin D hormone functions in the intestine, bone, and kidney to stimulate transport of calcium and phosphorus into the extracellular fluid compartment upon demand. The production of the vitamin D hormone is tightly feedback regulated directly or indirectly by calcium and phosphorus levels of the plasma. The vitamin D endocrine system is an important one in the regulation of calcium and phosphorus metabolism but is not solely responsible for the calcium and phosphorus transfer reactions occurring during reproduction. The vitamin D hormone functions in the target organs by a nuclear-mediated receptor-based mechanism probably involving the biogenesis of calcium and phosphorus transfer proteins. New target sites of 1,25-(OH)2D3 action in several tissues are suggested by this nuclear localization in those cells. Study of the vitamin D endocrine system has provided a new understanding of metabolic bone diseases and has provided new forms of vitamin D for their treatment. Thus a basic investigation of the regulation of calcium and phosphorus metabolism has rewarded medicine and science with new therapeutic approaches to disease problems.

25-Hydroxyvitamin D3 1-alpha-Hydroxylase↗
PubMed1994

Immunity and the endocrine system.

In conclusion, interaction between the immune and endocrine systems is highly complex. Generally, abnormalities of T suppressor cells, a result of HLA antigen genetic abnormalities, result in autoimmunity that causes endocrine gland destruction and hormone deficiency, as seen in lymphocytic thyroiditis of dogs, type I DM, hypoparathyroidism, hypoadrenocorticism, and APS. On the other hand, endocrine deficiency (hypothyroidism, DM) or excess (hyperadrenocorticism) states may cause abnormalities of cell-mediated and antibody-associated immunity, leading to susceptibility to a variety of viral, bacterial, and fungal infections. It is hoped that this article sheds some light on the complex and highly integrated endocrine-immune interactions.

Adrenal Insufficiency↗
PubMedDate not supplied

[Epidemiological study on special features of prevalence of disorders of the endocrine system among rural population living in different ecological conditions].

An epidemiological study was made on special features of prevalence of disorders of the endocrine system among the rural population over the period 1992-1996 based upon 8 regions of Ukraine. The role has been ascertained of ecological factors in modification of contingent prevalence of endocrine diseases. A hypothesis has been framed that there is the "exposure-->effect" type relationship between abnormal levels of radiation contamination and risk for origination of disorders of the endocrine system and increase in endocrine morbidity.

Endocrine System Diseases↗
PubMed1989

Effects of repeated dosing of zopiclone on endocrine system in male rats.

The effects of a minor tranquilizer, zopiclone, on endocrine system in male rats were assessed to clarify the mechanisms whereby large doses of zopiclone may induce testicular damage. 1) Zopiclone had no significant effect on plasma and tissue levels of hormones of the hypophyseo-gonadal or -thyroid system in rats given 10, 100 and 250 mg/kg/day orally for 28 days. 2) Rats given zopiclone in doses of 10 and 100 mg/kg/day orally for 14 days had lowered serum levels of PGE2 and PGF2 alpha but the testicular PGF2 alpha concentration remained unchanged. Therefore, oral administration of high doses of zopiclone to rats has no evident influence on endocrine system related to male reproduction. And these findings support our previous paper that repeated dose of zopiclone cause no significant change in plasma or epididymal TS levels, nor to any change in lipid peroxidation in testicular tissues.

Animals↗
PubMed2004

Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems.

Bilaterian animals are notably characterized by complex endocrine systems. The receptors for many steroids, retinoids, and other hormones belong to the superfamily of nuclear receptors, which are transcription factors regulating many aspects of development and homeostasis. Despite a diversity of regulatory mechanisms and physiological roles, nuclear receptors share a common protein organization. To obtain the broad picture of bilaterian nuclear hormone receptor evolution, we have characterized the complete set of nuclear receptor genes from nine animal genome sequences and analyzed it in a phylogenetic framework. In addition, expressed sequence tags from key lineages with no available genome sequence were also searched. This allows us to date the evolutionary events that led from an ancestral nuclear receptor gene, in an early metazoan, to present day diversity. We show that there were approximately 25 nuclear receptor genes in Urbilateria, the ancestor of bilaterians, at which point the fundamental diversity of the subfamily was already established. Surprisingly, differential gene loss played an important role in the evolution of different nuclear receptor sets in bilaterian lineages. The nuclear receptor distribution was also shaped by periods of gene duplication, essentially in vertebrates, as well as a lineage-specific duplication burst in nematodes. Our results imply that the genes for major receptors such as steroid receptors or thyroid hormone receptors were present in Urbilateria.

Animals↗
PubMedDate not supplied

Different shapes of the steroid hormone 1alpha,25(OH)(2)-vitamin D(3) act as agonists for two different receptors in the vitamin D endocrine system to mediate genomic and rapid responses.

Vitamin D(3) produces biologic responses as a consequence of its metabolism into 1alpha,25(OH)(2)-vitamin D(3) [1alpha,25(OH)(2)D(3)] and 24R,25(OH)(2)-vitamin D(3). The metabolic production of these two seco steroids and their generation of the plethora of biologic actions that are attributable to the parent vitamin D(3) are orchestrated via the integrated operation of the vitamin D endocrine system. This system is very similar in its organization to that of classic endocrine systems and is characterized by an endocrine gland (the kidney, the source of the two steroid hormones), target cells which possess receptors for the steroid hormones, and a feed-back loop involving changes in serum Ca(2+) that alter the secretion of parathyroid hormone (a stimulator of the renal 1-hydroxylase) which modulates the output by the kidney of the steroid hormones. There are, however, at least two unique aspects to the vitamin D endocrine system. (a) The chemical structures of vitamin D and its steroid hormones dictate that these be highly conformationally flexible molecules present a wide variety of shapes to their biologic environments. (b) It is now believed that 1alpha,25(OH)(2)D(3) produces biologic responses through two distinct receptors which recognize totally different shapes of the conformationally flexible 1alpha,25(OH)(2)D(3). Thus, the classic actions of 1alpha,25(OH)(2)D(3) to regulate gene transcription occur as a consequence of the stereospecific interaction of a modified 6-s-trans bowl-shape of 1alpha,25(OH)(2)D(3) with its nuclear receptor (VDR(nuc)). The ability of 1alpha,25(OH)(2)D(3) to generate a variety of rapid (seconds to minutes) biologic responses (opening of chloride channels, activation of PKC and MAP kinases) requires a planar 6-s-cis ligand shape which is recognized by a putative plasma membrane receptor (VDR(mem)) to initiate appropriate signal transduction pathways. This report summarizes the evidence for the specificity of different ligand shapes and the operation of the two receptor families for 1alpha,25(OH)(2)D(3).

Animals↗
PubMed1977

The morphology of the endocrine system in congenitally athymic (nude) mice.

The endocrine system (adenohypophysis, thyroid, adrenals, ovaries, testes) and the submandibulary salivary gland of both female and male congenitally athymic (nu/nu) B10LP mice at various ages post partum (2, 4, 6, 8 and 12 wks) were studied morphologically and compared with their heterozygous thymus-bearing (+/nu) littermates. The animals were held under conventional conditions. The adenohypophysis of male nu/nu mice showed a decrease in size of the acidophilic cells. In the thyroid glands a slight hyperactivity of the follicles was seen in both female and male nu/nu mice in comparison with the +/nu mice. No changes were observed in the adrenals. The ovaries of the nu/nu females showed degeneration in the follicles while the corpora lutea were absent or, if present, degenerated. In the testes of nu/nu mice only a slight retardation in spermatogenesis was seen at wk 4. In the submandibular salivary glands of the nu/nu males the normal sex-dependent presence of well-developed tubular structures was absent from wk 4 onwards. The results were compared with those described in the literature for athymic mice with another genetic background and for thymectomised mice. It was concluded that alterations in immunological reactivity in athymic mice are not necessarily due to changes in the immune system, but may also be dependent on changes in endocrine function.

Adrenal Glands↗