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At least 73 records · Page 4Linked to original sources
PubMed2001

[Clinical study on regulatory effect of liandai Capsule on p21ras and mutant p53 protein expression in gastrointestinal neoplasm].

OBJECTIVE: To study the regulatory effect of Liandai Capsule on p21ras and mutant p53 protein expression in gastrointestinal (GI) neoplasm. METHODS: Forty-five patients of GI neoplasm in middle or advanced stage were enrolled and divided randomly into the treated group and the control group to observe the changes of their serum p21ras and mutant p53 protein expression as well as their quality of life (QOL) before and after treatment. RESULTS: The content of p21ras and mutant p53 protein expression in the treated group decreased significantly and QOL improved after treatment, P < 0.05 or P < 0.01, while these changes in the control group were not shown. CONCLUSION: Liandai Capsule has regulatory effect on p21ras and mutant p53 protein expression in GI neoplasm.

Adenocarcinoma↗
PubMed1993

[Intraoperative ultrasonography in the diagnosis of liver metastasis from gastrointestinal neoplasms].

The authors illustrate their experience in the systematic use of intraoperative ultrasonography of the liver in patients undergoing surgery due to gastrointestinal cancer. The liver is the organ in which metastases from colorectal, stomach, pancreatic, and biliary cancer are most often localised. Between January 1991 and April 1992 95 patients underwent intraoperative ultrasonographic controls of the liver. In all cases the liver was studied using traditional image diagnosis: standard ultrasonography and CAT. On the basis of their experience the authors observed 12 cases negative for metastases using CAT and traditional ultrasonography which were positive using intraoperative ultrasonography, 2 cases which were positive for secondary hepatic lesions using traditional diagnostic tools but negative following histological tests guided by intraoperative ultrasonography. In the case of false negatives using traditional methods, those metastases revealed by intraoperative ultrasonography were above all located deep down and in segments which are difficult to explore, or were so small that they were not visible or palpable during intraoperative controls of the viscera. Intraoperative ultrasonography of the liver has been found to be a more sensitive test (97% of the best series) than standard ultrasonography (65%) or CAT (43%). Higher resolution due to the characteristics of the method is coupled with the possibility that intraoperative ultrasonography may be used to guide biopsies of the metastases revealed, thus allowing histological confirmation to be obtained: for this reason the risk of false positives is virtually zero.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2001

Role of magnetic resonance imaging in the staging of gastrointestinal neoplasms.

A concise review is presented of the current applications and techniques of magnetic resonance imaging (MRI) in the field of diagnostic imaging of oncologic disease of the gastrointestinal tract, with a summary of the diagnostic possibilities of MRI in the various types of tumor pathology of the gastrointestinal tract. We conclude with a review of the specific situations in which MRI presents distinct advantages over other diagnostic imaging methods (such as computed tomography and ultrasound).

Contrast Media↗
PubMedDate not supplied

[Aorto-iliac aneurysms and associated gastrointestinal neoplasms. Treatment problems].

In patients affected by aortoiliac aneurysm the concurrent presence of a gastrointestinal tumor is a not infrequent occurrence which poses problems of therapeutic approach (one step operation or prior treatment of one of the two diseases; in the latter case definition of timing and sequence of the surgical treatment). Three cases are reported where an eclectic therapeutic approach has enabled satisfactory results. A patient with an isolated aneurysm of right hypogastric artery associated with rectal cancer was treated with percutaneous embolization of the aneurysm and subsequent excision of the tumor. In a patient with a neoplasm of the left colon and aortic aneurysm, the aneurysm was treated first and after about a month the tumor was resected. In a patient with gastric cancer and aortic aneurysm subtotal gastrectomy was first performed and subsequently, after about 3 months, the aneurysm was treated by extraperitoneal route. Even if an unidirectional approach cannot be defined, it is thought that the two-step treatment of the associated diseases is preferable. In the presence of non stenosed non bleeding colorectal tumors it seems more suitable to treat the aneurysm first (increased postoperative risk for rupture of the aneurysm; more difficult preparation of subrenal aorta in the presence of cicatricial outcomes of colonic surgery; persistence of perianastomotic infections after colonic resection). Gastric tumors should be treated first for their higher biological aggressiveness and unfeasible correct preoperative staging. In particular cases (single unilateral aneurysm of a hypogastric artery associated with gastrointestinal cancer), non surgical treatment of the vascular lesion (embolization during angiography) is the treatment of choice.

Adenoma, Villous↗
PubMedDate not supplied

Immunohistochemical detection of carcinoembryonic antigen in esophageal carcinomas: a comparison with other gastrointestinal neoplasms.

BACKGROUND: Although the prognostic value of Carcinoembryonic antigen (CEA) in colorectal cancer follow-up is well known, CEA expression in esophageal cancer is not widely recognized and studies correlating tissue CEA expression in stomach cancers with tumor differentiation have yielded contradictory results. We compared the CEA expression in esophageal, gastric and colorectal carcinomas in order to elucidate its diagnostic and prognostic significance and to evaluate the potential role of tissue CEA localization for the clinical evaluation of esophageal carcinomas. MATERIALS AND METHODS: CEA expression in 84 biopsies of carcinomas of the gastrointestinal tract (38 colorectal, 22 gastric, 24 esophageal) was evaluated by immunohistochemistry. RESULTS: Sixty-two percent of the squamous carcinomas of esophagus, all five esophageal adenocarcinomas arising in Barrett esophagus, 86 percent of gastric adenocarcinomas and 89 percent of colorectal adenocarcinomas were CEA-positive. In colorectal and gastric adenocarcinomas, CEA staining was present, usually at the luminal membrane of neoplastic glands and in intraluminal material. Signet ring cells were strongly positive for CEA. In esophageal carcinomas staining was mostly cytoplasmic and in the better differentiated tumors it was particularly prominent at the center of epithelial pearls. Intensity of staining was highest in well-differentiated carcinomas and lowest in poorly-differentiated carcinomas. CONCLUSION: A clear correlation was seen between the degree of tumor differentiation and CEA expression for carcinomas of the esophagus, stomach and colon. Our results support the potential usefulness of CEA for monitoring the recurrence of gastric or esophageal tumors. Immunohistochemical determination of tumor CEA content could be a useful adjunct for the management of gastrointestinal carcinomas, by improving interpretation of serum CEA levels.

Adult↗