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PubMed1976

The glycerylphosphorylcholine content of the rat epididymis after injecting alpha-chlorohydrin and ligating the vasa efferentia.

The concentration of GPC in the 4 segments (initial segment, caput, corpus and cauda) of the rat epididymis was examined at various times (4 hours. 2, 5, 10 and 20 days) following injection of a lesion-forming dose (90 mg/kg body weight) of alpha-chlorohydrin and bilateral ligation of the vasa efferentia. There was a reduction in the overall GPC concentration of the epididymis 2 days after both treatments and a further decrease until 20 days when a slight increase occurred. It is suggested that a lesion-forming dose of alpha-chlorohydrin, like ligation of the vasa efferentia, could inhibit the synthesis and/or release of GPC within the epididymis by blocking off androgen supply in the testicular fluid.

Animals↗
PubMed1989

Glycerylphosphorylcholine diesterase activity of uterine fluid in conditions inducing secondary sex ratio change in the rat.

Food restriction or decreasing the ratio of [Na+, K+] to [Ca++, Mg++] in the diet of female rats before conception favoured the production of female offspring. Seven days of food deprivation decreased uterine fluid GPC diesterase activity in female rats, whereas long-term food restriction (21 days), rather than decreasing the enzyme activity, apparently stimulated it. Dietary Ca and Mg supplementation, likewise, produced significant decrease in GPC diesterase activity. A significantly positive correlation was observed between the levels of uterine GPC diesterase and secondary sex ratio change, which indicates that these dietary techniques of sex-ratio manipulation may modulate the uterine fluid GPC diesterase activity and influence sex determination in utero.

Animals↗