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Bilateral hypoglossal nerve palsies following head injury are very rare, with only two cases previously being reported. We present the case of an 11-year-old boy who developed this disorder after being struck by a car, and discuss the mechanism of injury, which is most likely traction on the hypoglossal nerve.
Palsies of the lower cranial nerves caused by a compressive pathological carotid artery are not common. Three cases of paralysis of the hypoglossal nerve, hypoglossal and vagus, hypoglossal, glossopharyngeal and vagus nerves, are reported. In 2 patients the symptoms were related to an extracranial carotid artery aneurysm below the base of the skull and in 1 patient to a spontaneous carotid dissecting aneurysm. It is possible that some localized arterial dissecting aneurysms evolve to a localized aneurysmal sac, especially if they are located between Cl and the base of the skull. The tongue paralysis disappeared in 2 patients.
Seventeen cases of free-muscle transplantation using the hypoglossal nerve as a recipient motor nerve for the treatment of long-standing or irreversible facial paralysis are reported with details of a follow-up study. The muscle, usually the latissimus dorsi muscle, is transferred to the cheek with microvascular anastomoses. The muscle's motor nerve is sutured to the hypoglossal nerve. There are three classifications of hypoglossal nerve sectioning: total section, central section, and lower section. The results were compared on the basis of these three methods, leading to the recommendation that branches of the hypoglossal nerve diverging inferiorly to innervate the suprahyoid muscles be utilized as a recipient motor source. This method permits acceptably natural movement of the grafted muscle without functional disability of the tongue. Good candidates for this procedure are considered to be those patients for whom muscle transplantation combined with a cross-face nerve graft cannot be adopted because of bilateral paralysis or surgical intervention on the healthy side of the face or who are so old that the long two-stage operation holds no hope for them.
We report a boy with isolated hypoglossal nerve palsy that recovered within twelve weeks. Investigations of the cervix, base of the skull, medulla and hypoglossal nerve by CT-scan and MRI did not show any abnormal findings. There are a few reports concerning isolated unilateral hypoglossal nerve palsy with benign course. Although we could not establish the cause of our patient's disease, an awareness of this condition should save such patients from unnecessary invasive studies.
OBJECTIVE: Cadaveric dissections were performed to review the intracranial and extracranial course of the hypoglossal nerve. The neurological significance of a newly defined "triple cross" of the hypoglossal nerve is discussed. MATERIALS AND METHODS: 10 cadaveric heads (left and right; 20 sides) were dissected using microsurgical techniques. RESULTS: In the cisternal segment of hypoglossal nerve, the diameter of the rostral trunk amounted to 155-680 microm (mean 435 microm), and the caudal trunk to 210-820 microm (mean 482 microm). The roots formed three trunks in 20% of the hypoglossal nerves and two trunks in the rest. As a first cross, the anterior medullary segment of the vertebral artery crossed the hypoglossal nerve roots in 14 of 20 sides (70%). As a rare variation, the vertebral artery extended medial to the nerve (25%) or between its roots (5%). The second cross was found between the descendens hypoglossus and the occipital artery (75%), sternocleidomastoid artery and vein complex (15%) and external carotid artery (10%). The third cross was shown in the submandibular triangle between the lingual hypoglossus and its drainage vein; vena committans nervus hypoglossus. CONCLUSION: Throughout its way, the hypoglossal nerve passes over vascular structures in three crossing points which may serve as a probable cause of hypoglossal nerve entrapment disorders.
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Isolated hypoglossal nerve palsy (IHNP) although a rare condition, has been previously reported. A literature review revealed that in most cases, IHNP indicates the presence of an intracranial or extracranial space occupying lesion, head and neck injury, vascular abnormality, infection, autoimmune disease or neuropathy. Reports of idiopathic cases are rare and the vast majority of IHNP are reversible. We report a case of persistent idiopathic unilateral hypoglossal nerve palsy, with an emphasis on the investigations necessary to be undertaken on presentation of such a lesion.
The developmental morphology of the hypoglossal nerve and associated structures were studied in the chick embryo (Hamburger and Hamilton stages 16-27) stained by the immunohistochemical technique. Ventral rootlets of the occipital nerves, including O1, were seen at stage 16. The distal ends of these nerves anastomosed to form the hypoglossal nerve at stage 20. At stage 23, four occipital and the first three cervical nerves were observed to be involved. The transient contribution of C3 at this stage seemed to be correlated with the formation of the longitudinal anastomosis of the distal end of the spinal nerves which begins around stage 23. The anterior hypoglossal roots appeared between O1 and the abducens nerve at stage 20. These rootlets were observed to arise as the rostral continuation of the occipital sequence and were found to be arranged in a straight line from O1 to the abducens nerve. The recurrent branch of the abducens was also observed. The posterior end of the ganglion crest produced dorsal root ganglion (DRG)-like structures transiently at the level of C2, and sometimes at the level of C1 also. The ganglion crest developed descending processes in the occipital region seemingly related to the spinal dorsal root formation. These phenomena seemed to represent the potential of the ganglion crest to produce the spinal nerve components which are depressed in the occipital region.
BACKGROUND: The aim of the study was to use magnetic resonance (MR) imaging to determine the cause of hypoglossal nerve palsy and the sites of injury in patients with nasopharyngeal carcinoma before radiation therapy and during postradiation therapy follow-up. METHODS: The clinical records and MR studies of 21 patients with hypoglossal nerve palsy were retrospectively studied. These 21 patients belonged to a cohort of 387 patients with nasopharyngeal carcinoma (153 with newly diagnosed disease and 234 on postradiation follow-up) who underwent MR imaging in a 2.5-year period. RESULTS: Four patients had hypoglossal nerve palsy at initial diagnosis and all of them had extensive skull base invasion from tumor extending postero-inferiorly to the level of the foramen magnum. The nerve was invaded in the carotid sheath (3), hypoglossal nerve canal (3), and premedullary cistern (1). In 17 patients developing hypoglossal nerve palsy after radiotherapy, only two (12%) had evidence of tumor recurrence. Radiation-induced neuropathy was the probable cause in 14 patients and 1 case was judged indeterminate. MR evidence of fibrosis was demonstrable along the course the nerve in four patients (29%), involving the carotid sheath (4), hypoglossal nerve canal (2), and premedullary cistern (1). No patient had MR evidence of radiation change in the brain stem. Seven patients had a history of a boost dose of radiation to the parapharyngeal region on one or both sides, and nerve palsy occurred on the boosted side in six of them. CONCLUSION: Hypoglossal nerve palsy on presentation was caused by locally advanced nasopharyngeal tumor whereas a palsy arising after radiation therapy was more frequently caused by postradiation damage rather than cancer.
An isolated unilateral hypoglossal nerve lesion is an uncommon cranial nerve palsy. We report a case of isolated hypoglossal nerve paralysis caused by an intra-dural synovial cyst. To our knowledge, this is the first reported case of a twelfth nerve paralysis caused by a synovial cyst. The anatomy of the hypoglossal nerve, its blood supply and the relationship of the nerve to the atlanto-occipital joint are reviewed, along with the common causes of isolated hypoglossal nerve paralysis.
OBJECTIVE: To assess whether preoperative computed tomography (CT) scan can determine if the hypoglossal nerve (cranial nerve XII) will be sacrificed in floor-of-mouth, oral tongue, and tongue base tumor resections. STUDY DESIGN: Retrospective review. METHODS: Patients who underwent resection of floor-of-mouth, oral tongue, and tongue base tumors from 1990 to 1999 were identified. Preoperative CT scans were reviewed by a neuroradiologist. The postoperative status of cranial nerve XII was predicted to be "saved" or "sacrificed." Hypoglossal nerve "sacrifice" was predicted if the fat planes surrounding the takeoff of the proximal lingual artery were obliterated by tumor. The nerve was determined to be sacrificed or spared during resection by review of the operative report. RESULTS: Of the 45 patients, 14 tumors were predicted radiographically to involve the hypoglossal nerve. Twenty-seven of 31 nerves that were predicted to be saved were saved at the time of surgery. Seven of 14 nerves that were predicted to be sacrificed were sacrificed at the time of surgery. The sensitivity was 0.64 (95% confidence interval [CI], 0.35-0.86) with a specificity of 0.79 (95% CI, 0.70-0.87). The positive predictive value was 0.50 (95% CI, 0.27-0.68) with a negative predictive value of 0.87 (95% CI, 0.77-0.95). CONCLUSIONS: The ability to predict preoperatively whether a tumor can be resected without sacrificing the hypoglossal nerve would be an important factor in determining management of these tumors. The results indicate that CT scan accurately predicts the ability of the surgeon to spare the hypoglossal nerve (negative predictive value, 87%) with a specificity of 0.79.
Isolated hypoglossal nerve paresis as a manifestation of Behcet's disease has not been reported. We describe a 42-year-old man with isolated unilateral hypoglossal nerve paresis, who had had a five-year history of recurrent orogenital aphthae and relapsing arthritic manifestations. It is suggested that the nerve disorder represents a form of mononeuritis that may occur in Behcet's disease.
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BACKGROUND: In the literature the possibility of a pressure trauma to the hypoglossal nerve between the root of the tongue and the ligamentum stylohyoideum is discussed. A recent in vivo study examined the effects of forced reclination of the head on the nerve. PATIENT: A left sided hypoglossal nerve paralysis occurred in a patient after an endoscopically controlled endonasal operation under general anesthesia with transoral intubation. RESULTS: Clinically and electrophysiologically the palsy seemed to be transient due to neurapraxia. An X-ray of the neck performed after the operation revealed a calcification of the left ligamentum stylohyoideum. All the other diagnostic studies (ultrasound of the neck, neurological examination, serological tests, and CT scan of the head) did not show any abnormalities. This is the first time, that a postoperative hypoglossal nerve palsy has been observed, which could not be explained by extensive stretching or pressure. CONCLUSION: We believe that the short pressure of the Mcintosh spatula produced the hypoglossal nerve palsy described.
An anomaly of the hypoglossal nerve was discovered during a procedure to anastomose the 12th and 7th cranial nerves. This anomaly is described, and an embryologic mechanism is proposed to explain the occurrence of this particular anomaly. The surgical anatomy of the hypoglossal nerve is reviewed, and reasonable approaches to the surgical identification of the hypoglossal nerve are discussed.