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PubMed1992

Contrast material iodides: potential effects on radioactive iodine thyroid uptake.

The levels of contaminant, free inorganic iodide and iodine were determined in several commonly used ionic and nonionic intravenous contrast media to gain a better understanding of the roles of these compounds in radioactive iodine uptake inhibition. The method, which involved a reduction-oxidation reaction using sodium nitrite, yielded accurate and precise data for the iothalomate based ionic contrast media as well as the nonionic contrast media. There was no free iodine in any of the contrast media tested. There was considerable variation in free iodide levels, ranging from 1.38 microgram/ml to 20.84 microgram/ml among the different contrast media, although significant differences between the ionic and nonionic media were not found. These levels of contaminant iodide are thought to play a role in the short-term inhibition of radioactive iodine uptake.

Contrast Media↗
PubMed1976

Further studies on response of blood thyroid hormone level to its acute depletion by isovolemic exchange transfusion.

Groups of rats weighing about 400 g and fed low iodine diet for 16 days were injected with 125I- daily from day 8 to 14. Two days later their blood thyroid hormone was acutely depleted with an isovolemic exchange transfusion of hormone-free blood cell suspension. Relative changes of total plasma radioactivity and iodinated compounds were measured at frequent intervals, maintaining isovolemia of the recipient animal. In normal animals a post-transfusion decrease of total plasma radioactivity was related to the degree of exchange of total blood volume as was the post-transfusion increase to the initial level. No post-transfusion increase of total plasma radioactivity or labeled thyroxine was found in thyreidectomized animals. On the other hand, in normal animals a post-transfusion increase of plasma labelled thyroxine was observed. A linear increase of labeled iodide in plasma was found in both normal and thyroidectomized rats, the mechanism of which in thyroidectomized animals may be explained by a reflux of iodide from peripheral tissues to the blood. In normal animals a TSH-induced release of iodide from thyroid due to TSH action may participate in this phenomenon.

Animals↗