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PubMed1975

[Infant development and adipositas (author's transl)].

The present paper tries to answer the question, how far the degree of adipositas during adult age can be affected by influences from early childhood. Our special interest concerned the relation between the number of fat cells and adipositas. To answer this question we had to clarify some methodical problems. The difficulty was to find out in a statistical way the part of fat tissue in total body weight. Therefore we introduced the idea of variability of tissues supposing that the different tissues can be influenced in a different way by environmental factors. Bone tissue turned out to be the most steady in contrary to fat tissue as the most unstable one. We stated the hypothesis that the differences between two groupes of equal sized individuals are based upon differences of fat tissue. Our material have been the age classes born in 1938 till 1951. Their environmental conditions during infancy and the age of 19 have been investigated. The result was that the conditions of life of 19-year-old men can be regarded as similar, whereas those of infants showed significant differences. The age classes 1945-1948 proved to be nourished more badly than the years before (1938-1944) and after (1949-1951). With these results corresponds stature, whereas no similar effects could be revealed in body weight. The conclusion of our paper is that regarding to adipositas no connection between infancy and adult age could be proved.

Adipose Tissue↗
PubMed1986

Why do so many small infants develop an inguinal hernia?

Prevalence and incidence of inguinal hernia in a representative sample of low birthweight survivors were determined by tracing children at 3 years of age. Prevalence was examined in relation to perinatal factors recorded in hospital case notes, using a logistic regression model to allow for confounding variables. Of the 1074 two year survivors, 995 (93%) were assessed. Seventeen per cent of 497 boys and 2% of 498 girls had a hernia by 3 years of age, a total cumulative prevalence of 9.2%: it was significantly increased by lower birth weight, male sex, neonatal intravenous feeding, and lack of respiratory disease. Neonatal illnesses were otherwise not associated with herniation, and most infants were well when they presented. Peak incidence was at the expected full term of gestation. Bilateral hernias were increasingly more common than unilateral hernias at lower gestational ages. It is proposed that causes of increased abdominal pressure in healthy neonates are important causes of herniation during a critical period of inguinal development.

Birth Weight↗
PubMed1988

[Infectious placentitis, its effect on the fetus and infant development].

A random sample of 1000 placentae has been screened for infectious affections. Placentitis induced most commonly by Mycoplasma, herpetic and respiratory viruses was found in 213 of the examined placentae. Bacterial and mycotic involvement presented in 14 of cases. Immunofluorescence technique employed for the agents investigation revealed relevant agents and antigens as well as infection-specific structural rearrangement. There are also nonspecific organ alterations resulting in its insufficiency and having a high predictive value for the future developments. Placenta appeared capable of nonspecific protection against infection based on interferon production. Prognosis for genital-atrium infection proved most unfavorable.

Bacterial Infections↗
PubMed1990

Pregnancy and delivery characteristics of women whose infants develop child cancer. A study based on registry information.

Data on all cancers among children born 1973-1984 were extracted from the Swedish Cancer Registry and linked to data in the Medical Birth Registry (1,268 cancer cases). For each case, two controls were selected, matched for maternal age, parity, county, and month of birth. A marginally increased risk of childhood malignancy was seen in the offspring of teenage mothers and at parity 1 and 4+. There was an excess among cases of the diagnosis physiological icterus. No statistically significant associations were found between childhood malignancy and infant sex, twinning, birthweight, non-chromosomal malformations, maternal smoking, or complications during pregnancy.

Adolescent↗
PubMed1978

[Heart-lung machine for babies and infants. Development, experimental and clinical testing].

In order to offer the benefit of open heart surgery to the very early age of even new born babies small shaped extracorporeal circulation facilities has been devised and constructed encouraging now the surgeon to an early anatomical correction of congenital heart disease. This heart-lung-machine is equipped with a sophisticated saftey control guaranteeing either a constant flow or a pressure controlled perfusion. Prior to clinical use it has been tested in extensive experimental series including mock circulation and experiments on dogs. First clinical applications in open heart surgery have been successful.

Animals↗
PubMed1990

[Use of ultrasonography to estimate fetal weight in premature infants. Development of a new mathematical formula].

In 73 pregnant patients at a gestational age under 36 weeks, who gave birth within 72 hours from the last US examination, mathematical equations were elaborated. The equations were aimed at predicting fetal weight by measuring the main US biometric parameters; the results were compared to the actual birth weight. A statistical analysis was performed using the "backward elimination" method. The linear equation that has provided with the best estimation of fetal weight is the following: fetal weight = 12.9875 BPD +29.5642 AD +28.8023 FL -3496.1265. According to this equation, about 95.22% of the variability of the unknown quantity (i.e. birth weight) can be ascribed to its correlation to the variables: biparietal diameter (BPD), abdominal diameter (AD) and femur length (FL). Estimated fetal weight by US, as calculated on the basis of biparietal diameter, abdominal diameter and femur length measurements, showed, in our study, a standard error of 143 g (9.02%) (R = 0.95).

Body Weight↗
PubMed1988

Vole infant development is influenced perinatally by maternal photoperiodic history.

Vole pups were maintained from the time of conception in the same short-day (SD) photoperiod (10 h light/day, LD 10:14); groups differed only with respect to SD photoperiodic histories of dams before gestation, which simulated those experienced by dams breeding in autumn (SD-2, 2 wk of short days), midwinter (SD-21), or late winter (SD-26). Compared with SD-2 pups, offspring born to SD-26 dams matured more rapidly with respect to body size and reproductive status. Several other somatic and behavioral measures indicated that winter preparedness was greatest in pups whose dams had experienced 2 wk and least in those that had experienced 26 wk of SD treatment before conception. A cross-fostering design, in which pups gestated in long (LD 14:10) or short photoperiods were reared postnatally in the same or opposite day length, indicated that several photoresponsive traits are influenced predominantly by prenatal photoperiod, others by postnatal day length, and others by both photoregimens. Information is communicated to fetuses about the length of time dams have been exposed to short day lengths before mating as well as about the day length prevailing during gestation. The changes induced by the mother in her pups pre- and postnatally likely facilitate adaptation of newly weaned voles to seasonally varying environmental conditions.

Animals↗
PubMed1990

Development of infants of drug dependent mothers.

Infants of mothers who used methadone, heroin, cocaine and other drugs during pregnancy were compared with a group of control infants over the first 30 mths of life. Results of repeated examinations with the Bayley Scales of Infant Development showed a difference between the groups in mental development. No differences were found in a non-verbal version of the mental scale, but infants of drug dependent mothers seem to have specific difficulties in early language development. In psychomotor development, in behaviour during testing and on a questionnaire on activity, infants of drug dependent mothers did not differ from the comparison children.

Child Behavior Disorders↗
PubMed1978

Continuous tracking of behavioral development in infants.

Infant development scales provide a one time measure of the number of scale items an infant performs and his standing relative to his age group. Repeated assessment indicates how many more items he can perform and whether his relative status has altered but does not measure actual changes in the same behaviors as development progresses. This paper discusses the importance of continuously measuring the same behavior over time as an alternative strategy. The developmental information is exemplified by the behavioral records of two infants observed over a 25-week period for changes in frequency and duration of three prone position motor responses.

Child Behavior↗
PubMed1992

The role of frontal lobe functioning in the development of infant self-regulatory behavior.

In the last two decades, there has been tremendous growth in two fields of study related to human infant development: (1) the development of neural processes during the early postnatal years and (2) the development of self-regulatory behavior. In an attempt to stimulate research on the relation between early brain development and self-regulatory processes, several hypotheses pertaining to the role of frontal lobe functioning in the development of emotion regulation during infancy are proposed. The results of a study of the relation between frontal electroencephalographic (EEG) activity and emotional behavior of 21-month-old infants are reported. It was found that increases in frontal lobe activation were associated with increases in emotional arousal, while EEG activity recorded from the parietal region showed either a reciprocal pattern of activation or did not change as a function of level of emotional arousal. These results provide evidence for the specialized role of the frontal lobe in mediating emotional behavior during infancy.

Age Factors↗
PubMed1986

Infant botulism. Three cases in a small town.

Through Dec 31, 1985, there have been six cases of infant botulism reported in Colorado. Three of these infants have lived in the same town of 800 people in western Colorado. Two of these three infants developed infant botulism within a six-month period in late 1981. The infants lived approximately 400 m apart; they had used the same crib at the time each developed botulism. A specimen from the crib yielded Clostridium botulinum, as did four soil samples from the town and house-dust samples from the home of a relative of the second infant. The third infant developed infant botulism in September 1984. This infant had not shared the crib. In this case, all seven samples of soil from various locations in the town yielded C botulinum, as did a sample of house dust from the home of this infant. The occurrence of these three cases in such a small town seems unlikely to be only coincidental. Investigations and reports of other such clusters may provide insight into modes of transmission of infant botulism.

Beds↗
PubMed1992

Vocal development in infants with Down syndrome and infants who are developing normally.

The development of early vocalizations was investigated with 13 infants who had Down syndrome and 27 infants who were developing normally at bimonthly intervals from 4 to 18 months of age. A perceptually based framework was used to categorize utterances according to their developmental relations with adult, well-formed, or "canonical" syllables. Over time, both groups demonstrated increased production of mature vowel and canonical consonant-vowel syllables (characterized by full vowels, consonants, and rapid, well-coordinated articulatory movements) and decreased production of less mature "quasi-vowel" and marginal syllables. Infants in both groups were also quite variable in vocal development, both within group and across time.

Child Language↗