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At least 73 records · Page 4Linked to original sources
PubMed1995

[New routes for infiltration: surgical wound infiltration].

Wound infiltration with a local anaesthetic may be used either to provide anaesthesia for superficial surgery or for postoperative pain relief. In the latter situation, its efficacy is real but remains moderate and usually requires a combination with other analgesics. Ilio-iguinal and ilio-hypogastric block has been shown to have an analgesic efficacy close to that obtained with a wound infiltration but the duration of analgesia may be longer. These blocks remain unfrequently used in adults.

Administration, Topical↗
PubMed1994

Evaluation of infiltrating ductal carcinomas with a DCIS component: correlation of the histologic type of the in situ component with grade of the infiltrating component.

Recently there has been an increase in the detection of DCIS, and there is much interest in establishing a new pathologic classification that has less subjective criteria than traditional methods and that more closely reflects the clinical behavior of the tumor. It is hoped that this will lead to a more rational approach to treatment of DCIS. In this study one such recently proposed classification has been applied to the DCIS component of 215 infiltrating ductal carcinomas, and this has been compared with the histologic grade of the tumors. There was a highly significant correlation between DCIS type and grade (chi 2 = 110.0, P < 0.0001); well- and intermediately differentiated DCIS were usually found in grade I and grade II tumors, respectively. Poorly differentiated DCIS was equally associated with grade II and grade III infiltrating carcinomas. Furthermore, in univariate analysis, the DCIS type correlated with disease-free (chi 2 = 17.1, P < 0.001) and overall survival (chi 2 = 13.97, P < 0.001). In a Cox multivariate analysis, which included histologic grade, the association between DCIS type and prognosis was lost because of the very close relationship between type and grade. These results support the validity of the new classification and reinforce the view that treatment of pure DCIS should be related to tumor type.

Adult↗
PubMed1981

Bupivacaine infiltration after lumbar laminectomy. Local infiltration in the control of early postoperative lumbar laminectomy pain.

This is a report of a double-bind controlled trial to test the hypothesis that peroperative local infiltration of the wound of lumbar laminectomy with bupivacaine produces a significant reduction in postoperative back pain. No such effect was demonstrated when the linear analogue was used to record the patients' subjective response to pain. It is suggested that this treatment is not indicated as a routine method.

Adult↗
PubMed1990

Characterization of the dermal infiltrates in Jessner's lymphocytic infiltrate of the skin, polymorphous light eruption and cutaneous lupus erythematosus: differential diagnostic and pathogenetic aspects.

In the present study a comparative immunohistochemical study was performed on skin biopsies from of patients with Jessner's lymphocytic infiltration of the skin (LIS), polymorphous light eruption (PLE), discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE) using a large panel of monoclonal antibodies against T cell differentiation antigens (CD3, CD4, CD8), immunoregulatory T cell subsets (CD7, 4B4, 2H4, Leu 8), B cells (CD22), activated cells CD25, OKT9, HLA-DR), Langerhans cells (CD1) and macrophages (Leu-M5). The results showed many similarities between LIS and PLE. The most important differences between these conditions and CDLE/SCLE were the high proportions of cells reactive with monoclonal antibody Leu-8 and the absence of T cells expressing HLA-DR antigens in LIS and PLE, suggesting absence of local T cell activation in these conditions. The differential diagnostic and pathogenetic aspects of these findings will be discussed.

Antibodies, Monoclonal↗
PubMed2004

Axosomatic synapses on granule cells are preserved in human non-infiltrating tumour or lesion-related and mesial temporal sclerotic epilepsy, but markedly reduced in tumour-infiltrated dentate gyrus with or without epilepsy.

Granule cells of the human hippocampal dentate gyrus were examined. In controls, granule cells displayed somatic spines and cell nuclei with small infoldings. In addition, the cytoplasm of human granule cells always displayed lipofuscin. Subsurface cisterns of endoplasmic reticulum were frequently observed in the human granule cells. Two types of axosomatic synapses were found; most frequently symmetric and less frequently asymmetric. Many of the axosomatic synapses were isolated by glial processes in tumour or lesion-related epileptic patients, but the ultrastructural characteristics of granule cells were not different from those of the control patients. Large bundles of reactive astroglial fibres appeared regularly in all layers of the dentate gyrus. In tumour infiltrated hippocampi, glial processes dominated the neuropil and the number of perisomatic synapses was markedly reduced. Reduction in the number of perisomatic synapses did not correlate with severity and duration of seizures but did correlate with the malignancy of the tumour. It is suggested that reduction of perisomatic inhibition may not be a characteristic of granule cells in the epileptic human dentate gyrus.

Adolescent↗
PubMed1989

Lymphocytes infiltrating human ovarian tumors: synergy between tumor necrosis factor alpha and interleukin 2 in the generation of CD8+ effectors from tumor-infiltrating lymphocytes.

Tumor-infiltrating lymphocytes (TIL) were isolated by enzymatic digestion and gradient centrifugation from 18 human ovarian carcinomas. These cells were cultured in a complete medium supplemented with recombinant interleukin 2 (IL2) alone or recombinant IL2 plus recombinant tumor necrosis factor alpha (TNF-alpha), and their growth and antitumor cytotoxicity were determined. TIL cultured in the presence of IL2 plus TNF-alpha (1000 units/ml each) for 6 days showed significantly higher cytotoxicity against fresh autologous tumor targets than did TIL cultured with IL2 alone (e.g., mean lytic units/10(7) cells for 8 TIL preparations were 290 versus 74; P less than 0.05). No differences in [3H]thymidine uptake or natural killer cell activity were observed among these TIL cultures. In titration experiments, optimal synergistic concentrations of IL2 and TNF-alpha were determined as 10(2) and 10(3) units/ml, respectively. Using these concentrations for culturing the TIL, effector cells developed which preferentially lysed autologous tumor and displayed a CD8+ phenotype (up to 75% positive). However, the autologous tumor cytotoxicity mediated by these cultured TIL on day 6 was short lived. By day 12, it was replaced by non-major histocompatibility complex-restricted, lymphokine-activated killer cell-like activity mediated by CD3-CD56+ effector cells. Simultaneously, the production of gamma-interferon and interleukin 1 decreased in these cultures. In contrast to TNF-alpha, anti-CD3 antibody synergized with IL2 to increase 2-3-fold TIL proliferation but not their cytotoxic activity against autologous tumor cell targets. These data suggest that TNF-alpha and IL2 synergize early in culture to induce tumor-reactive CD8+ effectors, some of which may be specific for autologous ovarian tumor cells. However, the conditions needed to sustain the specific autologous tumor responses in long-term cultures of human TIL remain to be determined.

Antigens, Differentiation, T-Lymphocyte↗
PubMed1988

Lymphocytes infiltrating human ovarian tumors. I. Role of Leu-19 (NKH1)-positive recombinant IL-2-activated cultures of lymphocytes infiltrating human ovarian tumors.

Tumor-infiltrating lymphocytes (TIL) were obtained from human ovarian tumors, expanded in the presence of IL-2 in culture and studied for cytotoxicity against fresh autologous and allogeneic ovarian carcinoma (CA) targets. TIL from ovarian tumors grew well in long term cultures, achieving from 8- to 682-fold expansion. TIL cultured with IL-2 were cytotoxic against both autologous and allogeneic fresh ovarian CA targets, and no specificity for autologous tumor could be demonstrated in any of the cultures. In all fresh TIL preparations, CD3+ lymphocytes were the major cell type and contained a high proportion (up to 51%) of activated (IL-2R+) cells as determined by two-color flow cytometry. Sorting of bulk TIL cultures followed by cytotoxicity assays identified the Leu-19+ cells, both CD3+ and CD3-, as effectors of cytotoxicity against autologous and allogeneic tumor cell targets. Cold target inhibition assays showed that allogeneic targets (both ovarian CA and a sarcoma) competed effectively with autologous ovarian CA targets for Leu-19+ effectors in TIL cultures. mAb to Leu-19 or Leu-2a did not block lysis of autologous targets by sorted effectors. OKT3 antibody augmented lysis of autologous targets by CD3+Leu-19- effectors only. These results show that non-MHC-restricted Leu-19+ effectors in cultures of TIL with 1000 U/ml of rIL-2 mediate lysis of autologous and allogeneic tumor cells. The CD3+Leu-19- cells, the main population in these cultures, do not mediate tumor lysis. To determine the phenotype of antitumor effectors in IL-2 cultures of TIL, cell sorting followed by functional assays are necessary.

Adult↗
PubMed1977

Treatment of ankle sprains with joint aspiration, xylocaine infiltration, and early mobilization. Ankle sprains treated with xylocaine infiltration and early mobilization.

Ninety-nine ankle sprains were arbitrarily divided into a control (54 patients) and a study (45 patients) group. Both groups were treated with elevation, ice compression wraps crutches, and early mobilization. In addition, the study group underwent ankle joint aspiration and local injection of the involved ligaments with 4-10 cc of 1% xylocaine. The difference between recovery times in the control group (mean, 10.7 days) and in the study group (mean, 4.4 days) reached statistical significance at p less than 0.001 by Wilcoxon two-sample test. Because there are inherent risks in this treatment, it is not recommended for all patients. However, for those requiring early remission of symptoms to allow early return to pre-injury activities, this treatment is suggested by the author.

Adult↗