Synthesis of N-monosubstituted 2-mercaptoethylamines with thioureido substituents.
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Mouse skin was exposed to doses of 1 250 to 3 000 rad using a helium ion beam with modal LET of 15 keV per micron. The skin reactions were evaluated for mice treated with a topical application of 10% MEA in a cream base or a placebo 15 minutes before irradiation. A comparison of the skin reactions indicated that the MEA treatment resulted in a DMF of at least 1.2. The implication for radiation therapy was discussed.
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