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[Problems in emergency surgery: acute mesenteric vascular occlusion].

Twenty-one cases of acute mesenteric occlusion are presented. Stress is laid on the difficulty of reaching a diagnosis in time to enable disobstruction to be carried out. In the reported series, diagnosis was established 1-8 days after the onset of symptoms. When radical surgery was performed (extensive resection occasionally coupled with right hemicolectomy), postoperative mortality was high and transit and nutritional problems brought about by the shortness of the residual gut were encountered.

Acute Disease↗
PubMed1989

Mesenteric vascular occlusion: a new diagnostic method using a radiolabeled monoclonal antibody reactive with platelets.

A new method for diagnosing mesenteric vaso-occlusive bowel disease with the use of radioimmunoscintigraphy was developed and tested in experimental models of arterial and venous disease, as well as in a model simulating bowel strangulation. The method involves the use of a monoclonal antibody fragment mixture that binds to platelets. The antibody was labeled with technetium-99m, and imaging was performed with a gamma camera in the planar and single photon emission computed tomography modes. This method allowed visualization of areas of ischemia of 1-6 hours duration in bowel loops in 19 dogs 90-180 minutes after injection of the radiolabeled antibody. No bowel radioactivity accumulation occurred in dogs that underwent the same surgical procedure but were given a nonspecific Tc-99m-labeled antibody or in normal dogs given the specific antibody. It appears that the radiolabeled antibody used, which has higher reactivity with human platelets than with dog platelets, will be a good agent for noninvasive diagnosis of mesenteric vaso-occlusive disease in humans. It may also play a role in the intraoperative determination of the extent and location of ischemic bowel segments.

Animals↗