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At least 73 records · Page 4Linked to original sources
PubMed2006

[No advantage to referring patients with acute myocardial infarction from a general hospital to an intervention clinic for percutaneous coronary intervention; comparison of mortality rates in 2000 and 2003 in the Meander Medical Centre, Amersfoort].

OBJECTIVE: To evaluate whether implementation of the 2000 Netherlands Society of Cardiology guideline 'ST-elevation acute coronary syndromes', which recommends the use ofpercutaneous coronary intervention (PCI), has reduced mortality and complication rates in a general hospital, and whether patient characteristics and outcomes are comparable to those reported in the Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT) 2 and 3 trials. DESIGN: Retrospective outcomes study. METHOD: Data from 2003 were compared with data from 2000 regarding patients with acute myocardial infarction who received thrombolysis at the Meander Medical Centre in Amersfoort, the Netherlands, or percutaneous transluminal coronary angioplasty (PTCA) after referral to an intervention clinic. Data included baseline characteristics, type of treatment, outcomes and complications. Age, sex and mortality ofall patients were compared to data from the ASSENT 2 and 3 trials. RESULTS: Data were included from 130/132 patients treated in 2003 and 145/145 patients treated in 2000. Baseline characteristics were comparable, except age: there were significant more elderly patients in 2003 (p = 0.006). After implementation of the guideline, significantly more patients underwent PTCA (odds ratio (OR) 4.41 (95% CI: 2.51-7.75)). After adjusting for confounding factors there was no significant difference in in-hospital mortality (adjusted OR 1.11 (95% CI: 0.48-2.60)), 30-day mortality and 1-year mortality. Significantly more minor complications were reported (OR 2.58 (95% CI: 1.07-6.19)). Significantly more women and patients older than 75 years were treated compared with the ASSENT 2 and 3 trials. The 30-day mortality rate was significantly higher compared with ASSENT 2 (OR 1.60 (95% CI: 1.07-2.41)) and ASSENT 3 (OR1.74 (95% CI: 1.14-2.66)). CONCLUSION: The implementation of new guidelines 'ST-elevation acute coronary syndromes' did not result in lower mortality or fewer complications.

Age Factors↗
PubMed1997

Endoparasitic helminths of the European eel, Anguilla anguilla, from four disconnected meanders from the rivers Leie and Scheldt in western Flanders, Belgium.

The endoparasitic helminth communities of the European eel, Anguilla anguilla (L.), were investigated in four meanders, cut off from the rivers Leie and Scheldt in western Flanders, Belgium. Six species of helminths (2 cestodes, 2 nematodes and 2 acanthocephalans) were found. The dominant parasite species was the nematode Anguillicola crassus (Kuwahara, Niimi et Itagaki, 1974) infecting 79% of the eel population with intensities up to 112 specimens per fish. At two localities no acanthocephalans could be found, whereas these parasites were very common at the other sites. The prevalence, mean intensity, intensity and abundance, their correlation to the body length, and the frequency distributions were analysed. The site selection of parasites is in relation to food composition and feeding habits of eels, physiological and structural differences in the intestine and possible interspecific competition were discussed.

Anguilla↗
PubMed1998

Meandering bullet in the pericardial sac: to remove or not to remove.

Patients with bullets in the pericardial sac without obvious myocardial injuries are rare, making it difficult to analyze the natural history and propose management approaches. We present the case of a meandering bullet in the pericardial sac and a review of the literature.

Adult↗
PubMed2005

Anastomosis of Riolan revisited: the meandering mesenteric artery.

The eponym anastomosis of Riolan suggests that Jean Riolan (1580-1657), a famous 17th century French anatomist, was the first to describe this mesenteric arterial connection between the superior and inferior mesenteric arteries. Riolan was a strong defender of traditional Galenic doctrine in medicine and proved a vigorous opponent of the new concept of the circulation of blood as exposed by William Harvey (1578-1657). As confirmed by examining his anatomy book published in 1649, it is unlikely that Riolan would have conceived an arterial collateral pathway in the mesocolon. He probably had observed vascular arcades running along the inner border of the colon. It was not until 1743 that Albrecht von Haller (1708-1777) gave a detailed description of the anatomy of the mesenteric arteries, referring to the arterial collateral connection between the superior and inferior mesenteric arteries as the Arcus Riolani in honor of an old master of anatomy.

Collateral Circulation↗
PubMed2005

A gamut of loops: meandering DNA.

Nucleoprotein complexes comprising short DNA loops (150 base pairs or less) are involved in a wide variety of DNA transactions (e.g. transcription regulation, replication and recombination) in both prokaryotes and eukaryotes, and also can be useful in designing nanostructures. In these higher-order nucleoprotein complexes, proteins bound to spatially separated sites on a DNA interact with each other by looping out the relatively stiff intervening DNA. Recent technological developments have enabled determination of DNA trajectories in a few DNA-loop-containing regulatory complexes. Results show that, in a given system, a specific DNA trajectory is preferred over others.

Bacterial Proteins↗
PubMed2001

Meanderings of the mRNA through the ribosome.

A map of how mRNA travels through the ribosome is critical for any detailed understanding of the process of translation. This feat has recently been achieved using X-ray crystallography. The structure reveals, for the first time, details of the interactions between the mRNA and the 30S subunit beyond those at the tRNA binding sites. Elements of both 16S rRNA and ribosomal proteins contribute to mRNA binding. This work also identifies two tunnels that the mRNA passes through as it wraps around the 30S subunit. The mechanisms and mechanics of reading frame selection, translational fidelity, and translocation can now be informed by the structure.

Codon↗
PubMed2005

Missense meanderings in sequence space: a biophysical view of protein evolution.

Proteins are finicky molecules; they are barely stable and are prone to aggregate, but they must function in a crowded environment that is full of degradative enzymes bent on their destruction. It is no surprise that many common diseases are due to missense mutations that affect protein stability and aggregation. Here we review the literature on biophysics as it relates to molecular evolution, focusing on how protein stability and aggregation affect organismal fitness. We then advance a biophysical model of protein evolution that helps us to understand phenomena that range from the dynamics of molecular adaptation to the clock-like rate of protein evolution.

Adaptation, Biological↗
PubMed2003

Myotome meanderings. Cellular morphogenesis and the making of muscle.

The formation of muscles within the vertebrate embryo is a tightly orchestrated and complex undertaking. Beyond the initial specification of cells to become muscle are several complex cellular movements and migrations, which lead to the positioning of muscle precursors at specific locations within the embryo. The consequent differentiation, elongation and striation of these cells results in the formation of individual muscles. Investigation of the in vivo morphogenesis of individual vertebrate muscle cells has only recently begun, and is being approached through the use of sophisticated cell labelling and lineage analysis techniques. However, a consensus about the mechanisms involved has yet to be achieved. This review outlines vertebrate embryonic muscle formation in chick, fish and mice, focusing on the embryonic myotome, which generates both the axial musculature and the appendicular muscle of the fins and limbs. We highlight the points of consensus about, and the complexity of, this developmental system, and propose an evolutionary context for the basis of these understandings.

Animals↗