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At least 73 records · Page 4Linked to original sources

Hypertension and chronic exposure to noise.

The effects of noise on various cardiovascular parameters are conflicting and uncertain. In the current study, the authors studied 52 workers who were employed in a bedframe factory who were chronically exposed to noise and who had poor hearing. An additional group of 65 workers who had jobs in the light-metal sector and another group of 64 office workers served as two control groups; none of the controls were exposed to noise, and none had hearing defects. Blood pressure was measured for each person in the supine and standing positions, and an electrocardiogram was also performed. Sound-level measurements were taken in the workplaces. Mean systolic and diastolic blood pressures and diastolic blood pressure distributions were significantly higher in the noise-exposed group than in both control groups. Among the three groups, there were significantly different frequencies of hypertension, drops in blood pressure, and electrocardiogram anomalies. Within the group of bedframe workers, those exposed to a personal daily level of exposure (i.e., equivalent continuous noise level for exposure to noise for each individual workers in an 8-hr shift) that exceeded 90 dBA had a higher mean diastolic blood pressure and a higher frequency of diastolic hypertension than workers exposed to a personal daily level of exposure of < 90 dBA. The findings suggested that (a) work performed by the bedframe group had some effects on the cardiovascular system, (b) noise is a cardiovascular risk factor, and (c) cardiovascular effects are relative to intensity and type of exposure. Vascular damage often accompanies auditory damage, but--depending on individual susceptibility--the cardiovascular system can respond in various ways.

Adult↗

Approach to stochastic modelling of consumer exposure for any substance from canned foods using simulant migration data.

A two-dimensional probabilistic model was constructed to estimate the short-term dietary exposure of UK consumers to any generalized migrant from coated light metal food packaging. Using three UK National Dietary and Nutrition Surveys (NDNS) comprising 4-7-day dietary surveys for different age and gender groups, actual body weights and survey years, a sample representative of the dietary consumption of the UK population was obtained comprising around 4,200 food items. Interrogation of the raw data showed that the per capita consumption of food and beverage for an adult was 2.9 kg per person day(-1), which is comparable with the US FDA value of 3.0 kg. The packaging type of each food item was assigned from the survey descriptions or by sampling from distributions based upon market share information and expert judgement. Each food item was assigned to the relevant food simulant: A (aqueous), B (acidic) or D (fatty), so that simulant migration data could be used. The exposure model was used to evaluate exposure for a given level of migration and, conversely, the level of migration that could be tolerated whilst keeping within a target threshold exposure level. As examples, migration at 10 microg dm(-2) into fatty foods only resulted in an exposure ranging from 0.06 to 0.22 microg kg(-1) body (actual) weight day(-1) depending on the scenario. The model revealed that if migration from metal coatings was only into fatty foods, migration in the range 1.83-4.95 microg dm(2) (97.5th percentile, depending on the scenario) would give an exposure of less than 1.5 microg per person day(-1). This is a toxicological threshold limit used in the USA. If migration into simulants A and B is also considered to be at the same level as that for simulant D, then the level of migration for the threshold to be reached is, not surprisingly, lower (0.64-0.87 microg dm(-2)) than that if migration were only into fatty foods. In this case, clearly the main contributors to the exposure were foodstuffs represented by simulants A and B because of their importance in the diet. These estimates are based on 4- or 7-day food diaries and chronic exposure over the long-term would be expected to be lower.

Adolescent↗

X-ray crystallographic study of the possible binding sites of the monovalent cations in the Z-DNA structure.

Determination of the binding positions of light metal ions in the structure of oligonucleotides remains a challenge owing to their irregular coordination geometries, low electron densities and mobility in the crystals. To study the interactions between monovalent cations and DNA, the heavier alkali metal ion Rb(+) was used to replace Na(+) and K(+) in the Z-DNA crystal and the structure was analyzed using X-ray cryocrystallography. The resolution of the Rb-d(CGCGCG)(2) crystal data set is 1.76 A, with an R(merge) of 0.061. The final residual factor (R factor) for the crystal structure is 0.175. The positions of 16 Rb(+) ions were tentatively assigned, with most of them having partial occupancies. Three rubidium ions with full occupancies coordinated to two DNA double strands were located in the Z-DNA crystal. The results of this work suggest that there are numerous relatively low-energy sites for binding of monovalent cations to Z-DNA and that these sites are cation-water hybrid positions.

Binding Sites↗

[Applicability of titanium in preparing dental prostheses for allergic patients].

Owing to its excellent biocompatibility, titanium has been used in health care, including dental care, for a long time. The unalloyed light metal is a non-allergic one, it resists corrosion, has low heat conducting ability, it tastes neutral and is relatively cheap to apply. Titanium's biocompatibility may be associated with its fast oxidizing capacity, which can inhibit its binding with proteins. Due to titanium's oxidizing capacity, its applicability in dentistry is difficult, because such prostheses are not easy to cover with ceramics, which is essential for aesthetic reasons. The bond between the ceramic, developed specially for titanium, and the metal surface is weaker than in the case of NiCr alloys or alloys of noble alloys. The strength of the bond, however, meets ISO requirements, and, according to the latest literature, it can be further strengthened by surface treatment techniques and new bond systems. These solutions are aimed at stopping cavity formation on the titanium surface and in the oxide phase (which would lead to the disjunction of the oxide phase at the interface). Comparative studies have mentioned problems with right marginal closure and precision of fitting, still they have found titanium-based prostheses acceptable. According to data in the literature the ceramic fused to titanium, and removed partial dentures are artificial dental structures which may offer an inexpensive, still aesthetically and functionally acceptable solution for certain patients suffering from metal allergy.

Biocompatible Materials↗

Genetic analysis of the pinna of the human ear: sex differences in college age adults.

Photographs of the left ears of 113 male and 197 female students of the University of Northern Colorado were taken using a 35mm camera with 50mm lens, small electronic flash, +4 close-up lens, and ASA 100 color film. Camera and flash attachment were mounted on a light metal frame positioning the camera 90 degrees to the head and a specific distance from the ear. Metric scale and counter were mounted so they were visible in the photograph. Eight vertical measures and eight horizontal measures were made, and 15 subjective-objective data taken. Means, variances, and interrelationships were determined. Mean height for males was approximately five inches greater than for females. Vertical measures were standardized by expressing ear/body height as a ratio. Three vertical measures--width of the superior helix, distance from superior helix to the edge of antihelix, and distance from antihelix to tip of the lobule--and three horizontal measures--width of the pinna, width of the posterior helix, and width of the notch--appear to be under specific genetic regulation in the two sexes.

Adult↗

Work conditions and accidents in three industries.

Four studies conducted in the light metal, electrotechnical and printing industries are described. The purpose was to determine the applicability of the systems approach to occupational accidents. The data consisted of 291 accidents and 701 controls. The stable characteristics of the workers or the environments were not good predictors of accidents. The clearest differences between the accidents and the controls involved the worker's situational experience, the frequency of task occurrence, the familiarity of the tasks, and the mobility of dangers. The complexity of the information exchange between man and his environment, as well as the perceptibility of environmental dangers, contributed to the occurrence of accidents.

Accidents, Occupational↗

Ophthalmic implants and explants.

There are a variety of relatively common implants and explants used in ophthalmology. The ED physician should be familiar with and recognize them when they present primarily or secondarily to the ED. The lids and lacrimal system harbor devices that improve physiologic function. The globe is home to the most common implant, the contact lens, and now increasingly, the intraocular lens after cataract surgery. Orbit fractures are often repaired with light metals or other alloplastic materials. The anophthalmic socket, depending on its age, has been filled with many types of implants, some of which may present years later with complications of migration or extrusion. All implants and explants used in ophthalmology can have complications and potentially appear in the ED. Complications that include ocular or orbital infections, especially sight-threatening intraocular infections, require immediate referral. The less-emergent problems mentioned can usually be seen in a few days. The need and timing of ophthalmic referral can be determined with a telephone consultation from the ED.

Emergencies↗

Differential ability of human cutaneous nociceptors to signal mechanical pain and to produce vasodilatation.

We investigated the ability of human nociceptive primary afferent neurons to encode mechanical pain and to produce vasodilatation. Pain was induced by shooting a light metal cylinder (0.3 g) at different velocities (6-18 m/sec) perpendicularly against the hairy skin of the hand. When single impact stimuli were applied, monotonically increasing stimulus-response functions were obtained in 10 psychophysical experiments using magnitude estimation techniques. In 35 microneurographic experiments nine unmyelinated afferents were recorded from the superficial radial nerve. All units responded readily to impact stimulation even at stimulus intensities that were not rated as painful. However, there was a close linear correlation between the number of action potentials evoked from the nociceptors and the psychophysical magnitude estimates of the perceived sensation or the stimulus intensity. This was also reflected by a corresponding increase of neurogenic vasodilatation. While two thin myelinated afferents displayed qualitatively similar responses 12 low-threshold mechanosensitive afferents (4 rapidly adapting, 5 slowly adapting type 1, 3 slowly adapting type II) failed to encode the intensity of the applied impact force and often became desensitized. This indicates that the total number of action potentials is the determinant of the magnitude of mechanical pain and the associated vasodilatation following single brief stimuli. By contrast, the close correlation between nociceptor activity and sensation changed when trains of mechanical impact stimuli (five stimuli of constant intensity, intratrain frequency of 1/32 to 2 Hz) were applied. Magnitude estimates of pain intensity were frequency dependent and stimuli with short interstimulus intervals were perceived as more painful than those delivered with long intervals. However, the total number of action potentials evoked from C-fibers was higher at longer interstimulus intervals than shorter intervals, thus yielding a negative correlation between the magnitude estimates of the perceived painful sensation and the number of action potentials elicited from nociceptive afferents. This suggests that temporal summation of the nociceptive discharge at central neurons becomes increasingly more important for the sensory discriminative experience of pain evoked by repetitive stimulation. We conclude that human nociceptive C-fibers signal brief noxious mechanical stimuli by the total number of action potentials evoked during a short period of time. However, with repetitive stimulation the total number of action potentials evoked from nociceptors is less important for evoking pain and temporal summation of the nociceptive primary afferent discharge becomes the crucial factor for signaling the magnitude of sensation.

Adult↗

Coupling of metal-based light-harvesting antennas and electron-donor subunits: trinuclear ruthenium(II) complexes containing tetrathiafulvalene-substituted polypyridine ligands.

Three new tetrathiafulvalene-substituted 2,2'-bipyridine ligands, cis-bpy-TTF(1), trans-bpy-TTF(1), and cis-bpy-TTF(2) have been prepared and characterized. X-ray analysis of trans-bpy-TTF(1) is also reported. Such ligands have been used to prepare two new trinuclear Ru(II) complexes, namely, [[(bpy)(2)Ru(micro-2,3-dpp)](2)Ru(bpy-TTF(1))](PF(6))(6) (9; bpy=2,2'-bipyridine; 2,3-dpp=2,3-bis(2'-pyridyl)pyrazine) and [[(bpy)(2)Ru(micro-2,3-dpp)](2)Ru(bpy-TTF(2))](PF(6))(6) (10). These compounds can be viewed as coupled antennas and charge-separation systems, in which the multichromophoric trinuclear metal subunits act as light-harvesting antennas and the tetrathiafulvalene electron donors can induce charge separation. The absorption spectra, redox behavior, and luminescence properties (both at room temperature in acetonitrile and at 77 K in a rigid matrix of butyronitrile) of the trinuclear metal complexes have been studied. For the sake of completeness, the mononuclear compounds [(bpy)(2)Ru(bpy-TTF(1))](PF(6))(2) (7) and [(bpy)(2)Ru(bpy-TTF(2))](PF(6))(2) (8) were also synthesized and studied. The properties of the tetrathiafulvalene-containing species were compared to those of the model compounds [Ru(bpy)(2)(4,4'-Mebpy)](2+) (4,4'-Mebpy=4,4'-dimethyl-2,2'-bipyridine) and [[(bpy)(2)Ru(micro-2,3-dpp)](2)Ru(bpy)](6+). The absorption spectra and redox behavior of all the new metal compounds can be interpreted by a multicomponent approach, in which specific absorption features and redox processes can be assigned to specific subunits of the structures. The luminescence properties of the complexes in rigid matrices at 77 K are very similar to those of the corresponding model compounds without TTF moieties, whereas the new species are nonluminescent, or exhibit very weak emissions relative to those of the model compounds in fluid solution at room temperature. Time-resolved transient absorption spectroscopy confirmed that the potentially luminescent MLCT states of 7-10 are significantly shorter lived than the corresponding states of the model species. Photoinduced electron-transfer processes from the TTF moieties to the (excited) MLCT chromophore(s) are held responsible for the quenching processes.

Journal Article↗

Metallic behavior of lightly doped La2-xSrxCuO4 with a Fermi surface forming an arc.

Lightly doped La2-xSrxCuO4 in the so-called "insulating" spin-glass phase has been studied by angle-resolved photoemission spectroscopy. We have observed that a "quasiparticle" (QP) peak crosses the Fermi level in the node direction of the d-wave superconducting gap, forming an "arc" of Fermi surface, which explains the metallic behavior at high temperatures of the lightly doped materials. The QP spectral weight of the arc smoothly increases with hole doping, which we attribute to the n approximately x behavior of the carrier number in the underdoped and lightly doped regions.

Journal Article↗

Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta.

The biological and pharmacological utility of nitric oxide (NO) has led to the development of many classes of NO-donor compounds as both research tools and therapeutic agents. Many donors currently in use rely on thermal decomposition or bioactivation for the release of NO. We have developed several photolabile metal-nitrosyl donors that release NO when exposed to either visible or UV light. Herein, we show that these donors are capable of activating the primary "NO receptor", soluble guanylate cyclase (sGC), in a light-dependent fashion leading to increases in cGMP. Moreover, we demonstrate that these donors are capable of eliciting light-dependent increases of cGMP in smooth muscle cells and vasorelaxation of rat aortic smooth muscle tissue, all effects that are attributed to activation of sGC. The potential utility of these compounds as drugs and/or research tools is discussed.

Animals↗

Suppressed light transmission through corrugated metal films at normal incidence.

In the study of light transmission through corrugated metallic film, it has been shown that along with the enhancement of light transmission, suppression may take place at specific values of the period and magnitude of corrugation for normal light incidence. Suppression was found to be due to the interplay between symmetric and assymetric surface plasmon polariton modes at their simultaneous excitation.

Journal Article↗

Osseointegration of metallic implants. I. Light microscopy in the rabbit.

Thirty-eight adult albino rabbits received one implant of pure titanium and one implant of another, test, material in each tibia. The test materials were titanium-aluminum-vanadium alloy, chrome-cobalt alloy, and stainless steel. Observation times were 4 months and 11 months. Light microscopy of the interface revealed a direct contact between bone and implant surface (osseointegration) in 73 of the 76 cases. The exceptions were two implants of pure titanium and one of stainless steel. Thus, given identical healing conditions, the modern implant metals were accepted by the bone in the same way. It is suggested that osseointegration should be regarded not as an exclusive reaction to a specific implant material, but as the expression of a nonspecific and basic healing potential in bone.

Alloys↗

Metal-assisted light-induced DNA cleavage activity of 2-(methylthio)phenylsalicylaldimine Schiff base copper(II) complexes having planar heterocyclic bases.

Ternary copper(II) complexes [CuLL'](ClO(4)), where HL is NSO-donor Schiff base (2-(methylthio)phenyl)salicylaldimine and L' is NN-donor phenanthroline bases like 1,10-phenanthroline (phen), dipyridoquinoxaline (dpq) and 2,9-dimethyl-1,10-phenanthroline (dmp), are prepared and structurally characterized by X-ray crystallography. The complexes have a distorted square-pyramidal (4+1) CuN(3)OS coordination geometry. While [CuL(phen)](ClO(4)) and [CuL(dpq)](ClO(4)) show axial sulfur ligation, [CuL(dmp)](ClO(4)) has the sulfur bonded at the equatorial site. The one-electron paramagnetic complexes exhibit axial electron paramagnetic resonance (EPR) spectra in dimethylformamide glass at 77 K. The complexes are redox active and a quasireversible electron transfer process near 0.0 V vs saturated calomel electrode (SCE) in DMF-Tris buffer (1:4 v/v at pH 7.2) involving Cu(II)/Cu(I) couple is observed for the phen and dpq complexes. The dmp complex exhibits an irreversible reduction process forming bis(dmp)copper(I) species. A profound effect of the substituents of the phenanthroline bases is observed on the binding of the complexes to the calf thymus (CT) and in the cleavage of supercoiled (SC) pUC19 DNA. The phen and dpq complexes show DNA cleavage activity in presence of mercaptopropionic acid (MPA). The dmp complex is cleavage inactive in presence of MPA. All the complexes show photocleavage activity when irradiated with a monochromatic UV light of 312 nm. The dpq complex also cleaves SC DNA on visible light irradiation at 436, 532 and 632.8 nm but with a longer exposure time and higher complex concentration. The cleavage reactions in presence of MPA are found to involve hydroxyl radical. The photocleavage reactions are found to occur under aerobic conditions showing an enhancement of cleavage in D(2)O and inhibition with azide addition suggesting formation of singlet oxygen as a reactive species. The roles of sulfur of the Schiff base as photosensitizer and the phenanthroline bases as minor groove binder, and their influence on the photocleavage activity are discussed. The quinoxaline ligand exhibits significant photosensitizing effect assisted by the copper(II) center.

Animals↗