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PubMed2003

Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats.

The 5-HT(3) and 5-HT(4) receptor antagonists alosetron and piboserod, and the muscarinic receptor antagonists PNU-171990A (2-(diisopropylamino)ethyl 1-phenylcyclopentanecarboxylate, hydrochloride) and PNU-174708A (2-(diisopropylamino)ethyl 1-phenylcyclohexanecarboxylate) were studied by electromyography, defining the migrating myoelectric complex (MMC) after i.v. administration in conscious rats. Alosetron prolonged the MMC cycle length from 16.6 to maximally 30.4 min at the dose 0.5 mg kg(-1). Piboserod promptly abolished MMC pattern and prolonged cycle length from 16.5 to >60 min at 0.5 mg kg(-1). PNU-171990A and PNU-174708A had no effect on basal cycle length up to a dose of 20 mg kg(-1). In controls, saline did not change the MMC pattern, while L-hyoscyamine at the same dose, 20 mg kg(-1), prolonged cycle length from 17.6 to 29.0 min. None of the drugs affected duration or propagation velocity of phase III of MMC. Blockade of 5-HT(4) receptors seems to exert a powerful inhibitory effect on motility, 5-HT(3) receptor blockade is less efficient and muscarinic receptor blockade has low efficacy.

Animals↗

PubMed1991

The relationships between glucose absorption and insulin secretion and the migrating myoelectric complex in the pig.

Net glucose and free amino nitrogen absorption and insulin output in the pig hepatic portal vein were calculated from portal-arterial concentration differences and portal blood flow measured by thermodilution. Duodenal and jejunal motility were assessed by electromyography. In the fed pig, the migrating myoelectric complex (MMC) pattern of motility persisted; glucose and amino nitrogen absorption and insulin secretion all varied with the phase of the MMC, rising to maximum values 19.4 +/- 3.1 min before and falling to minimum values 16.7 +/- 4.4 min after phase III. The variations in glucose absorption with the MMC were caused primarily by changes in duodenal and jejunal motility rather than by changes in the rate of gastric emptying as glucose absorption and insulin secretion varied with the phase of the MMC during duodenal glucose infusions, with maximum values occurring 24.4 +/- 3.3 min before and minimum values 14.9 +/- 2.5 min after phase III activity. The mean glucose absorption time calculated by timing the appearance of glucose in the portal vein following an intraduodenal bolus injection was significantly longer when given in phase I showing that absorption was less rapid when the intestine was not contracting. A significant amount of glucose is metabolized by intestine, as during glucose infusion (500 mg min-1) the average portal glucose absorption (376 mg min-1) was less than the glucose infused.

Animals↗

PubMed1983

Regulation of the fasting enterohepatic circulation of bile acids by the migrating myoelectric complex in dogs.

UNLABELLED: The purpose of this study was to correlate the fasting enterohepatic circulation (EHC) of bile acids with the migrating myoelectric complex. Four dogs were surgically provided with a functional cholecystectomy, a duodenal cannula for direct vision cannulation of the common bile duct, and 12 bipolar electrodes implanted from stomach to terminal ileum. Bile was collected in equal-volume, timed aliquots over 6 to 10 h. Aliquots were sampled and either returned to the duodenum for study of the intact EHC, or collected and retained in order to study the time course of the bile acid pool washout. In the washout experiments boluses of radiolabeled taurocholic acid were instilled into the duodenum before and after duodenal phase III of the migrating motor or myoelectric complex (MMC). In another group of experiments the bile acid pool was washed out and during a continuous duodenal infusion of taurocholic acid bile was collected to study the pattern of hepatic secretion. RESULTS: (a) In all experiments, a single broad peak of bile flow and bile acid secretion occurred at 35-55% of the MMC migration time. At this time the MMC had migrated to a point 70-85% of the distance along the small intestine. (b) During bile acid pool washout the peak of bile flow and bile acid secretion occurred with the distal migration of the first MMC and then bile flow and bile acid secretion rates decreased to a minimum and stabilized. (c) In bile acid pool washout experiments the radiolabeled bile acids instilled into the duodenum prior to duodenal phase III were secreted and peaked with peak endogenous bile acid secretion. The secretion of radiolabeled bile acids instilled into the duodenum after duodenal phase III was delayed until the subsequent cycle of the MMC. 88% of the bile acid pool collected over 6 h was secreted during the distal migration of the first MMC (2.4 +/- 0.4 h). (d) After bile acid pool washout and during continuous duodenal infusion of taurocholic acid, hepatic bile flow and bile acid secretion continued to fluctuate with the same pattern observed with the EHC intact. CONCLUSIONS: (a) In the fasting state, the transport of intestinal bile acids to the liver is pulsatile rather than continuous and is determined by the MMC. Maximum hepatic secretion occurs when phase III of the MMC propels the intraluminal bile acid pool to its site of absorption in the distal small bowel. (b) The "housekeeping" action of the MMC is very efficient and clears 88% of the 6-h washout bile acid pool in one pass.

Animals↗

PubMed1998

Nociceptive inhibition of migrating myoelectric complex by nitric oxide and monoaminergic pathways in the rat.

This study investigated the role of nitric oxide (NO) and adrenergic and dopaminergic mechanisms in reflex inhibition of the migrating myoelectric complex (MMC) after intraperitoneal administration of acid in rats. Acid instilled immediately after an activity front inhibited the migrating complex and prolonged the cycle length from 13.0 +/- 0.7 to 98.5 +/- 17.2 min (P < 0.001). Administration of N omega-nitro-L-arginine, reserpine, or guanetidine before acid decreased the prolonged cycle length to 18.1 +/- 2.8 (P < 0.001), 19.0 +/- 2.0 (P < 0.001), and 27.5 +/- 9.3 min (P < 0.001), respectively. Similarly, haloperidol given before acid shortened the prolonged cycle length to 46.7 +/- 5.2 min (P < 0.05). There was no effect of phentolamine in combination with propranolol or hexamethonium given alone. After intraperitoneal instillation of acid there was an increase in the plasma levels of somatostatin and a decrease of calcitonin gene-related peptide, but there was no change of neuropeptide Y, vasoactive intestinal peptide, substance P, neurokinin A, or neurotensin. The results indicate that NO and adrenergic, dopaminergic, and somatostatinergic mechanisms cooperate in inhibiting the MMC after nociceptive stimulation of the peritoneum.

Animals↗

PubMed2004

Chaotic behavior of gastric migrating myoelectrical complex.

Nonlinear feedback induces oscillation, whereas dynamic equilibrium between positive and negative nonlinear feedback generates rhythm. Physiological rhythms are central to life. No absolutely stable or periodic rhythm exists in living tissues. It has been extensively reported that many rhythms in human and animal organs, such as the heart and brain, are, in fact chaotic. The aim of this paper is to investigate whether the migrating myoelectrical complex (MMC) of the stomach was chaotic. The study was performed in eight healthy female hound dogs (15-22 kg), implanted with four pairs of bipolar electrodes on the serosa of the stomach along the greater curvature. After the dogs were completely recovered from the surgery, one complete cycle of gastric MMC was recorded from the serosal electrodes. Using Takens' embedding theorem, two parameters reflecting chaotic behavior, the attractor and the Lyapunov exponent of the myoelectrical recording, were reconstructed and computed, respectively. Statistical analysis was performed to investigate the difference in the Lyapunov exponents among different phases of the MMC. The results show that the MMC of the stomach is chaotic. Different phases of the MMC are characterized with different shapes of the attractors and different values of Lyapunov exponents. The characteristic chaotic behavior of the gastric MMC may be utilized for the identification of different phases.

Algorithms↗

PubMed1982

Neural control of the intestinal migrating myoelectric complex. A pharmacological analysis.

A pharmacological analysis of the participation of autonomic nerves in the control of the intestinal migrating myoelectric complex (MMC) was conducted on six conscious fasting dogs with implanted bipolar electrodes. All dogs exhibited regularly recurring MMC's. Hexamethonium (2-10 mg/kg i.v.) or atropine (25-100 micrograms/kg i.v.) immediately suppressed all spiking activity, stopped the progression of the ongoing complexes, and prevented the initiation of new complexes for 2.5 to 5 h. Phentolamine (2-4 mg/kg i.v.) and propranolol (2 mg/kg i.v.) given separately or in combination had no observable effect on any of the different phases of the complex, its progression, or its frequency. Phenylephrine (0.5-1 mg/kg) inhibited the spiking phases of the complex. Isopropylnoradrenaline had no effect on the complex at doses (up to 30 micrograms/kg) which produced maximal cardiac chronotropic effect. The effects of these agonists were totally blocked by the doses of respective adrenergic antagonists used. Phenoxybenzamine given in a dose of 10-15 mg/kg i.v. produced effects similar to atropine apparently owing to blockade of cholinergic muscarinic receptors. It is concluded that (a) the regular spiking phases of the migrating complex result from cyclical and sequential activation of preganglionic fibers forming nicotinic synapses on postganglionic cholinergic excitatory neurones; and (b) the function of adrenergic nerves is not normally required for the MMC.

Animals↗

PubMed1990

5-Hydroxytryptamine affects rat migrating myoelectric complexes through different receptor subtypes: evidence from 5-hydroxytryptophan administration.

The effect of the serotonin precursor 5-hydroxytryptophan (5-HTP) on jejunal migrating myoelectric complexes (MMCs) was investigated in conscious rats. Subcutaneous administration of low doses of 5-HTP (1-2 mg/kg) shortened the period between migrating complexes, whereas high doses of the compound (4-8 mg/kg) disrupted the MMC pattern. The serotonin (5-HT2) antagonist methysergide (8 mg/kg s.c.) did not alter basal MMC, neither did it prevent the effect of a low dose of 5-HTP; conversely, it antagonized the disruption due to the high dose. The 5-HT3 antagonist ICS 205-930 (30 micrograms/kg s.c.) decreased MMC frequency; administration of 2 mg/kg 5-HTP following ICS 205-930 brought the frequency of myoelectric complexes back to basal values. Both effects of 5-HTP were prevented by the decarboxylase inhibitor benserazide (85 mg/kg i.p.), which per se caused a transient inhibition of spiking activity. The results suggest that rat MMCs can be influenced in a composite fashion by progressively increasing concentrations of 5-HT, which in turn activate different receptor subtypes. A peripheral neuronal receptor, probably belonging to the 5-HT3 subclass, mediates the increase in MMC frequency observed after low doses of 5-HTP; higher levels of serotonin activate 5-HT2 receptors, causing disruption of cycling activity. Additionally, 5-HT3 receptors, but not 5-HT2, appear to be relevant for the regulation of the MMC pattern by the endogenous amine.

5-Hydroxytryptophan↗

PubMed1985

Morphine initiates migrating myoelectric complexes by acting on peripheral opioid receptors.

The role of peripheral and central opioid receptors in morphine-induced migrating myoelectric complexes (MMECs) was studied in conscious dogs implanted with silver-silver chloride electrodes. In normal fasted dogs morphine (100-200 micrograms/kg iv) initiated phase III of the MMEC in the duodenum. Once initiated the MMEC propagated distally. This effect of morphine was blocked by the opioid receptor antagonists naloxone (2 mg/kg iv) and N,N-diallylnormorphinium bromide (4 mg/kg iv). Higher doses of morphine (300-600 micrograms/kg iv) initiated phase III activity in fed dogs as early as 20 min after feeding, while lower doses (150 micrograms/kg iv) initiated phase III activity routinely when administered 100 min after feeding. In dogs with bilateral vagotomies and bilateral thoracolumbar sympathetic chain ganglionectomies, morphine (150 micrograms/kg iv) initiated phase III activity in the duodenum, which then migrated distally. This study demonstrates that morphine initiates phase III of the MMEC by acting through peripheral opioid receptors.

Animals↗

PubMed1992

Relation between slow-wave frequency and spiking activity during the migrating myoelectric complex in dogs.

The quantitative relation between slow-wave periods and spiking activity was evaluated in vivo in canine small intestine during the fasted state. Experiments were performed in three conscious dogs with three bipolar electrodes, implanted respectively 10, 25 and 40 cm beyond the ligament of Treitz. Digitized electrical recordings were automatically processed for the individual slow-wave periods and spike-burst intensities using a set of computer programs developed in our laboratory. A linear correlation existed between the degree of spiking activity and the average length of the preceding slow-wave period. The slopes of the regression lines were less steep for more distal electrodes. A second series of experiments showed that an increase in the slow-wave period precedes the onset of phase 3 of the migrating myoelectric complex and that a fall in slow-wave period precedes the end of phase 3. These data show that a low slow-wave frequency is accompanied by a facilitation of spiking activity, whereas shortening of the slow-wave period is accompanied by a decrease in spike burst intensity. This relation between slow-wave period and spiking activity shows an aboral trend that may be related to intrinsic slow-wave frequency.

Animals↗

PubMed1984

Somatostatin inhibits bombesin-induced effects on migrating myoelectric complexes in the small intestine of the rat.

The effect of i.v. infusions of bombesin and somatostatin, administered either separately or in combination, on migrating myoelectric complexes (MMCs) in the small intestine were studied in conscious, fasted rats. The myoelectrical activity was recorded by means of three bipolar electrodes chronically implanted into the duodenum and jejunum. Infusion of bombesin (0.5, 0.9 and 3 pmol . kg-1 . min-1) interrupted the MMC and induced irregular spiking activity similar to that observed on feeding. Only after the highest dose a consistent inhibition of the MMCs and a significant increase (P less than 0.05) of the spiking activity were achieved at all recording levels. Somatostatin (90 pmol . kg-1 . min-1) did not interrupt the MMC, but reduced significantly the incidence of the activity fronts and spiking activity of the MMCs (P less than 0.05). The effects of bombesin (3 pmol . kg-1 . min-1) on the MMC pattern were inhibited by simultaneous infusion of somatostatin (P less than 0.05). In a second series of experiments, using anesthetized rats, infusion of bombesin (0.5 and 3 pmol . kg-1 . min-1) increased the plasma concentration of neurotensin- gastrin-like immunoreactivities in a dose-dependent manner. The results show that bombesin alters the myoelectrical activity of the small intestine from a fasting to a fed pattern. Since the effect of bombesin was inhibited by the hormone release inhibitor somatostatin, it is suggested that the effect of bombesin on MMC may be secondary to the release of gastrointestinal peptides, such as neurotensin or gastrin.

Animals↗

PubMed1988

Biliary and pancreatic secretory component of the migrating myoelectric complex in the pig. Effect on intraduodenal pH.

The aim of the present study in the pig was to describe the biliary and pancreatic secretory component of the migrating myoelectric complex (MMC) during the interdigestive period and after feeding, and to examine the effects of the extracorporal diversion of biliary or pancreatic secretions on the MMC and on the cyclical variation of intraduodenal pH. In a first trial six pigs (50.6 +/- 1.6 kg) were fitted with a permanent catheter in the common bile duct (3 pigs) or in the pancreatic duct (3 pigs) to control the flow of these secretions. They also had a duodenal catheter to return the secretions, and antral and duodenal electrodes for simultaneous recording of motility in fasting conditions. In a second trial ten pigs (50.8 +/- 1.5 kg) underwent a similar surgical preparation (5 bile duct and 5 pancreatic duct fistulations). They had, in addition, a duodenal T-shaped cannula (19 cm distal to the pylorus) allowing continuous intraluminal pH recording parallel to the motility recording. Experiments included 4 situations: secretions returned under fed or fasted conditions; by-passed secretions in fed or fasted pigs. The flow of bile and pancreatic juice was very high during irregular spiking activity phases (ISA), peaking at the beginning of regular spiking activity phases (RSA); it was minimal during quiescent phases. The duration of the duodenal MMC and of its 3 constitutive phases was not modified by total extracorporal diversion of bile or pancreatic secretion either in the fed or fasted state. During the interdigestive period the pH was significantly reduced under bile diversion (quiescence: 6.17 vs 7.15; ISA: 4.91 vs 5.94; RSA: 5.40 vs 6.52) as well as under pancreatic juice diversion (quiescence: 5.56 vs 7.18; ISA: 4.21 vs 5.97; RSA: 5.14 vs 6.72). In fed pigs only bile diversion resulted in a small acidification during the postprandial pattern (5.07 vs 5.44) and the consecutive MMC cycles (quiescence: 5.81 vs 6.61; ISA: 4.66 vs 4.92; RSA: 5.11 vs 5.78). Nevertheless the periodicity of pH variation along the MMC cycle was unaffected in bile or pancreatic juice-deprived animals. It is concluded that a true biliary and pancreatic secretory component of MMC exists in the pig, and that these 2 secretions strongly contribute to the neutralization of the duodenal contents. However, the major determinant of the cyclical variation of the intraduodenal pH appears to be the periodicity of the acid gastric outflow.

Animals↗

PubMed1989

Involvement of serotonergic mechanisms in the disruption of ovine duodenal migrating myoelectric complex cycles by duodenal acidification.

Infusions of 1 and 4 mmol of HCl (pH 2.0) into the duodenal bulb of conscious sheep, within 30% of the period of the migrating myoelectric complex (MMC) cycle, induced aborally propagated premature phases of regular spiking activity (RSA) on the proximal duodenum. A transient inhibition of reticular contractions and a shortening of the period of subsequent duodenal MMC cycles were obtained with infusions of 4 mmol of HCl but not with infusions of 1 mmol. When the animals were pretreated with the 5-hydrotryptamine (5-HT) antagonists, ritanserin (0.2 mg/kg) and metergoline (0.5 mg/kg), 15 min before duodenal infusions of 4 mmol of HCl, premature RSAs and inhibition of reticular contractions were still elicited, but shortening of the subsequent duodenal MMC cycles did not occur. It is concluded that the shortening of duodenal MMC cycles induced by duodenal infusions of 4 mmol of HCl involved a serotonergic mechanism incorporating 5-HT2 receptors. The premature duodenal RSA and inhibition of reticular motility also elicited by these infusions appeared to be independent of this serotonergic system.

Animals↗

PubMed1985

Changes in the migrating myoelectrical complex of canine gastro-intestinal tract depending on the dietary regime.

Experiments were made to study the effect of vegetable protein (soya) and animal protein (meat) on the migrating myoelectrical complex (MMC) in the stomach and small intestine of dogs with chronically implanted electrodes. MMC was tested under different dietary conditions: (1) Diet No 1 comprising animal protein; (2) Diet No 2 poor in protein and diet No 3 with vegetable protein (soya). In the case of protein-deficient dietary regime (diet No 2) disturbance in MMC is observed--spike activity is constantly recorded. First phase of MMC is not observed. The transition from diet No 2 to diet No 3 at the end of the first week is accompanied by a tendency toward the formation of brief rest periods, with a considerable increase in the duration of 100% spike activity. At the end of the 30th day the different MMC phases were not well differentiated. Upon transition from protein-poor regime to diet No 1 during the second week, the different MMC of the stomach and small intestine are very well expressed. The problem of the generation and propagation of MMC is discussed. MMC is considered as a manifestation of the "biological clock" which responds to every change taking place in the organism during its interaction with the environment.

Action Potentials↗

PubMed1987

Motilin secretion and the migrating myoelectric complex in the pig.

The concentration of motilin in plasma from the abdominal aorta and the hepatic portal vein and the net portal motilin output varied with the phase of the migrating myoelectric complex (m.m.c.) in five of six pigs fasted for 17 h. Maximum concentrations and output occurred 9-12 min before phase III in the duodenum or upper jejunum. In fed pigs m.m.c.s occurred and the first phase III in the duodenum occurred within 90 min of feeding. Both portal and arterial motilin concentrations were reduced after feeding and no longer varied with the phase of the m.m.c. Altered secretion of motilin after feeding did not appear to be associated with absorption of glucose as infusion of glucose (50 g/l, 10 ml/min) into the duodenum raised arterial and portal plasma glucose concentrations to post-prandial levels yet motilin concentrations and output rates still varied with the phase of the m.m.c. Infusions of motilin (1 or 10 ng/kg X min) into the portal vein of 17 h fasted pigs did not induce an extra phase III or alter the duration of the m.m.c. Hydrochloric acid (100 mmol/l) infused into the duodenum of fasted pigs at 10-21 ml/min increased the concentration of motilin in the portal blood but was without effect at 5 ml/min. Rapid injections of 50 ml hydrochloric acid into the duodenum also increased the portal motilin concentration. Hydrochloric acid infusion or injection did not alter the interval between phase IIIs. It is concluded that motilin secretion is a consequence of the m.m.c. or shows the same periodicity as the m.m.c. but that motilin is not an important factor in the initiation and control of the m.m.c. in the pig.

Animals↗

PubMed1988

[Effect of bombesin on the frequency of slow potentials of the smooth muscles of the gastrointestinal tract and migrating myoelectric complex].

In dogs with electrodes implanted in the smooth muscle wall of the stomach, small intestine and colon, i.v. administration of bombesin (50, 100, 200 and 300 ng/kg) during the 2nd phase of the migrating myoelectric complex (MMC) increased the dose-dependent frequency of slow potential in the small intestine and stomach leaving unchanged the frequency of slow potentials in the colon. Single doses of 50 or 200 ng/kg bombesin during the 2nd phase of the MMC caused a short-term inhibition of the gastric and intestinal spike activity followed by its increase, the active period of the MMC being prolonged.

Action Potentials↗

PubMed1988

Participation of cholinergic mechanisms in the realization of the effect of bombesin on the migrating myoelectrical complex.

The experiments were carried out on dogs with chronically implanted bipolar ball-shaped silver electrodes in the antral part of the stomach and duodenum. The effect of bombesin (injected intravenously in a dose of 200 ng/kg) on the migrating myoelectrical complex (MMC) was examined after pretreatment with hexamethonium (10 mg/kg) or atropin (100 micrograms/kg), or alpha-antagonists (phentolamine, 2 mg/kg) and beta-antagonists (propranolol, 2 mg/kg) of the adrenergic receptors. Introduced during the second MMC phase, bombesin caused inhibition of the spike activity, accompanied by an increase of the slow potential frequency. Prolonged intensified spike activity occurred 5-10 min later. Early brief appearance of spike potentials was observed after bombesin in the presence of hexamethonium, which was not manifested on the background of atropin. After hexamethonium or atropin, however, the phase of the late activation of the spike activity did not occur and there was no change in the effect of bombesin on the frequency of the slow potential. The alpha- and beta-antagonists of the adrenergic receptors do not change the effect of bombesin on the electrical activity of the stomach and the intestines.

Animals↗

PubMed1984

Evidence for a propulsive function of the migrating myoelectric complex in rats.

In order to investigate the relation between myoelectric activity and the transport of small bowel luminal contents, recordings of migrating myoelectrical complexes (MMCs) were combined with studies of the propulsion of a bile-excreted radioactive test substance. At laparotomy, rats were provided with three pairs of bipolar electrodes, sewn to the seromuscular layer of the small bowel 15, 30 and 45 cm distal to the pylorus. After recovery for 1 week MMCs were recorded with the animal fasted for 18 h and in light barbiturate anesthesia. Concurrently, the bile-excreted radiopharmaceutic, 99mTc-Solco-HIDA, was infused intravenously. At the end of the experiment the rats were sacrificed and the distribution of 99mTc activity was recorded from the excised bowel specimen. In 12 animals with a typical MMC activity recurring every 20 min, the small bowel radioactivity was distributed into discrete portions, separated by fairly long empty segments. In 6 animals the experiments were terminated when an MMC activity front had reached one of the electrodes and in all, a portion of radioactivity was found to be located immediately distal to the position of that particular electrode. 6 control animals were killed when about 10 min had elapsed since the MMC front passed one of the electrode sites. In all these cases the electrode position was found to correspond to empty bowel segments. These data obtained from animals with permanent electrodes but an otherwise intact small bowel strongly support the notion that MMCs result in propulsion of luminal contents.

Animals↗

PubMed1982

Blood sugar oscillations and duodenal migrating myoelectric complexes.

Blood concentration of reducing sugar and electrical activity of the duodenum were simultaneously measured in four conscious pigs, each chronically fitted with a catheter in a jugular vein, a duodenal infusion catheter, and transparietal intestinal electrodes. After a meal, blood sugar concentration exhibited cyclic variations at a frequency similar to that of the migrating myoelectric complexes (MMC) observed on the duodenum (1.6 +/- 0.3 per h). During the fasting state (15 h), glucose or xylose infusions into the duodenum also induced blood sugar oscillations at the same frequency as that of duodenal MMC (0.9 +/- 0.3 per h). Injections of xylose boluses into the duodenum induced more rapid and larger increases in blood reducing sugar concentration when injected during the last two-thirds of the phase of irregular spiking activity or during the phase of regular spiking activity than when injected during quiescence or the first third of the phase of irregular spiking activity. It is concluded that intestinal motility is a prerequisite for optimal intestinal absorption of sugar that is markedly enhanced at the time of maximal digesta flow in the pig.

Animals↗