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At least 73 records · Page 4Linked to original sources
PubMed1969

[Multiple primary neoplasms in gynecology].

7054 malign neoplasms were observed at the I. Univ.-Frauenklinik of Vienna in the years 1950-1969. 142 cases were multiple primary neoplasms, i.e. 2.01%. In 51 cases the double neoplasms were situated in the genital region (local multiplicity), in 91 cases was there a separated multiplicity with the cancer of the breast dominating. A third of the multiple neoplasms was synchronous, the two other thirds were metachromatic with the peak in the first years after the diagnosis of the gynecologic neoplasm. 5 cases of triple neoplasms were specified.

Aged↗
PubMed1992

[A synchronous association of a double colonic adenocarcinoma and hypernephroma: an infrequent case of multiple primary neoplasms].

It has been reported that exceptional association exists between primary colon cancer and hypernephroma. In this paper we are reporting a case of a male patient carrying an hypernephroma synchronous with a proximal colonic adenocarcinoma in addition to a second adenocarcinoma, growing on a tubular adenoma, nearly of first. These findings get seen as partially coincidental with some features of the cancer family syndrome (Lynch syndrome II), and we have considered that genetics conditions, like those of Lynch syndrome II, could to explain some multiple neoplasms in patients carrying then.

Adenocarcinoma↗
PubMed1985

[Metastasis of one tumor into another in multiple primary neoplasms].

Eight patients had two tumours located in different organs: one of these tumours was carcinoma which metastasized into another, histologically benign neoplasm. Morphological characteristics of the two tumours, sources of metastases and metastasis "recipients", are described. The order of their clinical manifestations was followed up.

Aged↗
PubMed1995

[A case of a patient with multiple primary neoplasms: ileal leiomyosarcoma and bronchial carcinoid].

Small bowel leiomyosarcoma and lung carcinoid are uncommon neoplasms, and the association of these two neoplasms has never been reported in the literature. In the present article we report the case of a man who developed carcinoid of the lung three years after being operated for leiomyosarcoma of the small intestine. The short time elapsed between the two diagnoses adds further interest to this case.

Bronchial Neoplasms↗
PubMed1998

Multiple primary neoplasms in childhood: data from the German Children's Cancer Registry.

The German Children's Cancer Registry (GCCR) has documented all malignancies during the first 15 years of life in Germany since 1980. In a series of 20,388 cancer cases to the end of 1995, 127 children with multiple primary neoplasms up to the age of 15 years were identified. The children were monitored for 82,591 person-years with a mean observation time of 4.1 years. Relative and cumulative risk for the occurrence of second malignant neoplasms were estimated only for the first 15 years of life, as follow-up data beyond childhood are incomplete and valid data on the incidence of cancer in adolescents and adults are not available in Germany. The overall standardised incidence ratio for a second malignancy was 12.5 (95% CI: 10.4-14.9) which implies an absolute excess risk of 141.5 per 10(5). The estimated cumulative risk within 10 years after the first malignancy was 1.9% (95% CI: 1.5-2.3). It is expected that the risk will alter with prolongation of follow-up beyond childhood.

Adolescent↗
PubMed1995

Multiple primary neoplasms. Considerations on 42 cases.

During the years 1977-1993, 2,108 cases of gynecologic primary neoplasms were observed in the Department of Gynecology and Obstetrics of La Sapienza University in Rome. Forty-two cases were multiple primary cancers. Of these, 27 had multiple primary neoplasms involving only gynecologic sites, 15 had a neoplasm involving also another site; 3 patients had triple primary neoplasms. The most frequent neoplasm associations observed in our case series were: breast-ovary; endometrium-ovary; breast-cervix; endometrium-bowel (sigma-colon).

Adult↗
PubMed2004

Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco.

In this study conducted amongst Indian male tobacco users with upper aero-digestive tract (UADT) squamous carcinoma, 30 patients with multiple primary neoplasms (MPN) were compared with 28 age and sex matched patients with a single primary neoplasm (SPN) for various environmental factors (form of tobacco use, alcohol, radiotherapy for index cancer) and genetic parameters (family history of UADT cancers and GSTT1/GSTM1 genotype). The GSTM1/T1 null genotype, seen in 60% patients with MPN versus 33% patients with SPN (P=0.03) had an odds ratio of 3.7 [CI=1.14-11.99; P=0.03] for developing MPN. Tobacco use in the form of smoking with or without chewing, as opposed to only chewing, and regular alcohol intake were the two other factors with almost three fold increased risk for the development of MPN, although, the effect was not statistically significant. All three patients with a family history of UADT cancer developed MPN, suggesting an inherited predisposition.

Adult↗