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PubMedDate not supplied

[Benign neoplasms of the urethra in men].

A 20-year follow-up (1975-1994) in urological clinic of 107 males with benign tumors of the urethra (BTU) has determined that most commonly encountered BTU comprise viral papillomas (67.3%), polyps (22.4%), angiomas (10.3%). Viral papillomas and angiomas locate as a rule in the hanging urethra, while polyps arise both in the anterior and posterior portions. Urethral polyps and angiomas manifest most frequently with hemospermia, urethrorrhagia and terminal macrohematuria after coitus or exertion. Chronic nonspecific urethritis is thought to be a factor predisposing to urethral condylomas and polyps. Viral papillomas originate from the external orifice and Morgagni fossa spreading proximally. BTU are diagnosed primarily at urethroscopy and managed with transurethral resection, electrocoagulation, partial urethral resection which proved curative in many cases.

Adolescent↗
PubMedDate not supplied

Consideration of atherosclerotic plaques as benign neoplasms.

The monoclonal nature of atherosclerotic plaques, as well as their altered cell size, proliferation rate and function have led to the hypothesis that plaque tissue is analogous to benign tumors. To test this hypothesis, we have studied rates of DNA release by histologically-normal human arterial wall tissue and by early atherosclerotic plaques during incubation in a maintenance medium. No DNA was detected in media conditioned by normal arterial tissue after a 24 h incubation period, but plaque tissue (like benign tumors) released 10-100 ng DNA/ml during this period. These data offer additional support for the thesis that atherosclerotic plaques are similar to benign tumors.

Adult↗
PubMed1984

[Benign neoplasms of the soft tissues of the oral cavity].

The Authors, starting from a statistical study of Gennari et al., point out the frequency of the benign neoformations in the soft tissue of the oral cavity. They describe then the most frequently findable histological forms and the problems posed to the clinic and the surgeon by some histological forms such as the mixed tumours of the minor salivary glands and the fibropapillomatosis of the vestibular fornices. The Authors conclude stating that they not always are harmless neoformations and easily surgically excisable.

Fibroma↗
PubMed1985

Phenol as an adjuvant in the control of local recurrence of benign neoplasms of bone treated by curettage.

Throughout the present century phenol has been used to "sterilise" the edges of cavities left in bone after the clearance of benign tumours in order to reduce the risk of local recurrence. The results have been analysed of 165 benign bone tumours capable of local recurrence (aneurysmal bone cyst, chondroblastoma, giant cell tumour) treated with and without the use of phenol. The overall recurrence rate was 41% in 98 cases treated by simple curettage and 7% in 27 cases treated by curettage followed by the application of phenol.

Adolescent↗
PubMed1979

[Cryotherapy of benign neoplasms of the soft tissues in the maxillofacial area].

In the light of the relevant literature and of personal studies, the author deals with the possibilities of treating benign neoformations in the maxillofacial region by cryotherapy. The results are discussed from the aspects of cryophysical and cryobiological prerequisites. The extension in depth of the changes is the decisive criterion for cold application.

Cryosurgery↗
PubMed2005

[Stereotactic radiosurgery in the intracranial benign neoplasms and malignant tumors of the brain].

Stereotactic Radiosurgery has proven to be during the last years the therapy of choice in more and more patients with benign and malignant brain tumors. The potential advantages comparatively to surgery and conventional radiotherapy made this technique a very important tool in the therapeutic armamentarium of neurooncology. This series presents the experience of treating more than 100 intracranial lesions with linear accelerator-based radiosurgery at Hospital de Santa Maria in Lisbon with special emphasis on the indications and results. It also provides a review of the concepts and procedures of this modality as well as a general overview of the main published results in series of patients with brain tumors treated with stereotactic radiosurgery.

Adult↗
PubMed1998

[Benign neoplasms in the parotid gland in the county of Copenhagen 1986-1995].

In a ten year period from 1986-95 433 patients were submitted to operation due to benign tumours in the parotid gland in Copenhagen County. In this study we made a retrospective analysis of the surgical outcome. The incidence was calculated to be 6.8 benign tumours in the parotid gland per 100,000 persons per year. The histological distribution showed a frequency of 54% pleomorphic adenomas, 28% adenolymphomas and 18% other tumours. In the observation period there was a 3% recurrence rate in our material, most frequently the pleomorphic adenoma. The risk of permanent damage to the facial nerve was 1% for severe injury and 3% for affection of the ramus marginalis. Frey's syndrome was present in 50% of the patients, moreover the syndrome was observed many years after surgery. The frequency rate reached its highest level about five years postoperatively.

Adenolymphoma↗
PubMed1992

Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma.

Aggressive angiomyxoma of pelvic soft parts is a rare lesion with a high risk of recurrence. We report 10 cases of angiomyofibroblastoma, a hitherto uncharacterized benign tumor of the vulva histologically mimicking aggressive angiomyxoma. All patients had a vulval mass, often clinically diagnosed as a Bartholin's cyst. There was no recurrence after excision. The tumors were well circumscribed, measuring 0.5-12 cm in maximum dimension. They were characterized by alternating hypercellular and hypocellular edematous zones in which abundant blood vessels (predominantly of the capillary type) were irregularly distributed. Spindled, plump spindled, and oval stromal cells were aggregated around the blood vessels, sometimes forming solid compact foci, or were loosely dispersed in the hypocellular areas. Their nuclei were bland, but rare ones were enlarged and hyperchromatic in four cases. Some cells had abundant eosinophilic hyaline cytoplasm and eccentrically placed nuclei. Mitotic figures were absent or very sparse. Scattered throughout were thin, wavy strands or thick bundles of collagen. Mast cells were readily seen in eight cases. Immunohistochemically, the stromal cells were reactive for vimentin and desmin, but not cytokeratin, muscle-specific actin, alpha-smooth muscle actin, or S-100 protein. Ultrastructural studies showed well-developed rough endoplasmic reticulum, Golgi apparatus, abundant intermediate filaments, and pinocytotic vesicles in the stromal cells. Angiomyofibroblastoma can be distinguished from aggressive angiomyxoma by its circumscribed borders, much higher cellularity, more numerous blood vessels (which lack prominent hyalinization), frequent presence of plump stromal cells, minimal stromal mucin, and rarity of erythrocyte extravasation.

Adult↗
PubMed1990

Complex cytogenetic changes in benign neoplasms. Report of six lipomas.

We report the detailed cytogenetic findings from short-term cultures of six lipomas with complex chromosomal abnormalities. In all six cases, the abnormality occurred in two stages; an initial inversion, translocation, or insertion of the involved chromosome(s) followed by a subsequent rearrangement of the resultant derivative chromosome(s). A striking feature of these rearrangements was the consistent involvement of bands q13 - q14 on chromosome 12 in all the abnormalities. This region has been shown to be specifically rearranged in most of the lipomas studied. The other chromosomes involved in the rearrangements were chromosomes 1 in four cases, 5 and 9 in two cases each, and 2, 3, 4, 7, and 10 in one case each. Our findings and published findings show that, with a few exceptions, benign tumors that were previously considered cytogenetically normal, are characterized not only by specific numerical and structural changes but may also contain complex chromosome rearrangements that are generally considered a hallmark of advanced malignancy. In benign tumors, this suggests that the genes at the region of the breakpoints may represent proliferation-related genes or that benign tumors with such complex aberrations represent neoplasms potentially capable of undergoing transformation to malignancy, or both.

Adult↗
PubMed2003

Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.

An attempt has been made to identify the carotenoids present in the tissue of neoplastic tumors and the surrounding fatty tissue taken from women with histologically diagnosed cancer (ca ductale infiltrans, G2,G3; n=20) and those with benign changes (fibroadenoma, n=20). Carotenoid pigments were isolated using column and thin-layer chromatography. Prior to chromatography, the material was homogenized with acetone under nitrogen in dark glass bottles and the extracts kept in a refrigerator until analyzed. In the present study, we isolated 13 carotenoids belonging to provitamin A and nonprovitamin A carotenoids. The total content of carotenoids in microg/g of tissue was slightly lower in cancers and the surrounding fatty tissues in comparison to benign changes, but in general it was higher in the fatty tissue surrounding the tumors, irrespective of their histological structure (the mean values for cancers 20.433+/-10.64 vs fatty tissue 25.361+/-12.025, p<0.01; and the mean values for benign changes 22.889+/-12.011 vs fatty tissue 27.021+/-13.180, p<0.01). Epoxide carotenoids - lutein epoxide and violaxanthin, were predominant in fatty tissue, both in malignant and benign changes; epoxide carotenoids - mutatoxanthin and lutein epoxide and other carotenoids such as zeaxanthin, canthaxanthin, lutein and neoxanthin were predominant in neoplastic material. Beta carotene and lutein epoxide were found in all samples, alpha carotene was found in 50% of them. Antheraxanthin was present in fatty tissue only. Beta carotene, the main provitamin A carotenoid, content in the material examined ranged from 2.43 to 4.33% in tumor tissue and in fatty tissue surrounding the tumors it was twice as higs. Such carotenoids as 3'-lutein, canthaxanthin and astaxanthin were sporadic. No reoccurring carotenoid "sequences" were found despite the same histopathological diagnosis. No relationship was found between the neoplasm histopatological grade, lesion diameter and the occurrence of specific carotenoids.

Adipose Tissue↗
PubMed1993

Mantleoma. A benign neoplasm with mantle differentiation.

Four cases of neoplasms with mantle differentiation are presented. The mantle (sebaceous mantle) is a well-described but little known part of the sebaceous gland cycle. In the resting phase of that cycle, the mantle is seen as cords of undifferentiated cells that emanate from the infundibulum of a hair follicle and droop down aside the follicle in the form of a mantle or skirt. Cyclically, vacuolated sebocytes appear at the terminus of these cords, singly, then in groups, and finally as fully developed sebaceous lobules and glands. Presumably, sebaceous glands involute to become undifferentiated mantles. Clinically, neoplasms with mantle distribution occur on the face. Three of our cases were found fortuitously in sections of tissue removed because of basal-cell carcinoma. One was thought by the clinician to be a basal-cell carcinoma. Histopathologically, mantleomas vary in complexity. Presumably early neoplasms consist only of cords and columns of undifferentiated epithelial cells that radiate from an infundibulum. Later on, these cords interweave in a retiform pattern that contains sebocytes of varying degrees of vacuolization and sebaceous ductal structures. Mantleomas are benign because none in our series recurred after surgical removal and no atypical neoplastic cells were seen histopathologically.

Epithelium↗
PubMed1998

[Estrogen receptors in the malignant and benign neoplasms of the thyroid].

The etiology of thyroid carcinoma is multifactoral. The examples of etiologic factors are: deficit of iodine, genetic predisposition's, female sex, older age, irradiate in childhood, thyroid growth stimulating factors, and epidermal growth factor. Epidemiological data suggested that differentiated thyroid carcinoma depends on sex hormones, especially estrogen. The author have immunohistochemically studied estrogen receptors (ER) in many benign and malignant thyroid tumours. The cases included 8 papillary, 4 follicular, 4 anaplastic, and 1 Hurthle cell carcinomas, 15 follicular adenomas, 4 Hurthle cell adenomas, 8 adenomatous goiter, and 12 parenchymal goiter. Incidences of ER-positive cases were 4/8 in papillary carcinoma, 2/4 follicular carcinoma, 1/1 Hurthle cell carcinoma, 0/4 anaplastic carcinoma, 2/4 Hurthle cell adenoma, and 0/15 follicular adenoma, 0/8 adenomatous goiter, 0/12 parenchymal goiter. Estrogen receptors are commonly detectable in thyroid carcinomas (papillary carcinoma). Estrogens may play an important role as as a promoting factor in thyroid carcinoma. The results of future investigation will explain the possible role of hormones in thyroid pathology and the importance of the sex hormones receptors expression analysis for therapeutic detection.

Adolescent↗
PubMed1995

Spongiotic pericytoma: a benign neoplasm deriving from the perisinusoidal (Ito) cells in rat liver.

Spongiosis hepatis has been known for some time to develop frequently in livers of rats and fish treated with hepatocarcinogens and was considered to derive from the perisinusoidal (Ito) cells (PSC). Using rat liver treated with N-nitrosomorpholine at different dose levels, we studied the cellular composition and origin as well as the proliferation kinetics of spongiosis hepatis by immunohistochemical demonstration of desmin, vimentin, and alpha-smooth-muscle actin, and by autoradiographic determination of [3H]-thymidine incorporation, respectively. The vast majority of the cells forming spongiosis hepatis were positive for desmin and vimentin but negative for alpha-smooth-muscle actin, confirming the cellular origin of spongiosis hepatis from PSC. In addition, immunohistochemical demonstration of desmin and vimentin revealed that spongiosis hepatis is an integral part of larger lesions consisting of focal PSC aggregates. These aggregates show a significantly increased incorporation of [3H]-thymidine compared with PSC in the extrafocal tissue and in the liver tissue of untreated control animals. In stop experiments, this increased labeling index was maintained many months after withdrawal of the carcinogen, in line with the earlier observation of a progressive behavior of spongiosis hepatis. We conclude that PSC may give rise to proliferative lesions appearing as PSC aggregates associated with more or less pronounced spongiosis hepatis. The persistence, the proliferative activity, and the slow expansive growth of these lesions suggest a benign neoplastic behavior. We therefore propose to classify these lesions as spongiotic pericytoma. Malignant tumors possibly originating from spongiotic pericytoma should consequently by classified as perisinusoidal (Ito) cell sarcomas.

Animals↗
PubMed1985

Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.

Hexokinase (ADP: D-hexose-6-phosphotransferase, EC 2.7.1.1) was studied in human thyroid carcinomas (n = 11), follicular adenomas (n = 32), and normal thyroid tissue (n = 21). The specific activity was significantly increased in carcinoma (0.163 +/- 0.083 U/mg protein) compared with normal tissue (0.030 +/- 0.010 U/mg protein) (P less than 0.001). Specific activities of follicular adenomas are rather heterogeneous, but when subdivided into three groups according to histopathologic criteria, a significant difference was found between follicular adenomas group I and II and follicular adenomas group III. A lesser cellular differentiation of adenomas is indicated by the lower degree or even absence of colloid production and follicle formation. A higher proliferation rate may be assumed on the grounds of the irregularities in outline, the often defective pseudocapsule, and signs of compression of the surrounding tissue. The highest specific activity in adenomas was found in the group with the highest proliferative activity, i.e., group III, whereas the lowest specific activities were found in adenomas with the lowest grade of proliferation, i.e., group I; the former was comparable with values found in carcinomas and the latter was comparable with values found in normal thyroid tissue. An interesting difference was found when the compartmentation of hexokinase was compared in carcinomas of different degree of differentiation. In papillary carcinomas a significantly lower proportion of hexokinase (HK) is present in the cytosol in comparison to follicular and undifferentiated carcinomas. In carcinomas more HK II and less HK I was found in comparison with normal thyroid tissue. In contrast hexokinase isozyme composition and compartmentation in adenomas were not different from normal thyroid tissue.

Adenoma↗
PubMed1991

Intratumoral cytogenetic heterogeneity in a benign neoplasm.

Cytogenetic findings are reported in a 64-year-old man who had a history of rapid growth of a mass in the left groin area. The histopathologic diagnosis of the tumor was consistent with that of a lipoma with atypia. Cytogenetic analysis was done on an incisional biopsy specimen. The initial biopsy specimen revealed, in addition to normal cells, three different clones: 46,XY,t(12;21)(q13;q21), 46,XY, t(2;12)(q11.2'1.2), t(19;20)(q13.1'3), and 47.XY,+ r. The subsequently excised specimen showed a normal male karyotype (46,XY) and a predominant clone with the karyotype, 47,XY,t(2;12)(q11.2'1.2),t(3;11)(p24'5), + r. One cell with 47,XY, + r was present. In addition, polyploid cells with large markers, rings, and a high frequency of telomeric associations were also observed.

Chromosome Aberrations↗