[Further studies on children with cystic pancreatic fibrosis treated in the 2d Department of Pediatrics of the Medical Academy in Warsaw in 1959-1963].
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On the basis of the data available in the literature pertaining to the relatively high frequency of mucoviscidosis in children affected with Down's syndrome a hypothesis is advanced concerning the possible location of the mucoviscidosis gene in the chromosome 21. The author's own preliminary data are presented. Approaches to the verification of this hypothesis are described.
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A better knowledge of cystic fibrosis of the pancreas has contributed to raise the detection of cystic fibrosis in adults. We describe nine Mexican patients older than 15 years with cystic fibrosis. Respiratory symptoms were predominant and they were secondary to bronchiectasis. All patients were infected by mucoid Pseudomona aeruginosa and in some cases, the finding of this microorganism in sputum suggested the diagnosis. In Mexican population the cystyc fibrosis of the pancreas can be found in adult patients, and it should be considered in the differential diagnosis of chronic respiratory diseases in adults.
The present study is based on the typical dendritic forms of the sweat crystallization from patients with cystic fibrosis (CF). The phenomenon was analyzed in sweat collected by pilocarpine iontophoresis in 26 affected subjects (Homozygotes), 42 heterozygotes and 100 healthy-control subjects. The positive crystallization pattern (dendritic form), became useful in identifying the affected patients in 100% of cases and in differentiating them from the healthy-control subjects (100%, negative crystallization). The positive crystallization pattern was not altered by decreasing the electrolytes concentration in the sweat. This test could be a help to evaluate the diagnosis of cystic fibrosis.
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