Study on phagocytosis of leucocytes in tuberculosis. I. On the factors influencing phagocytosis.
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Polyvalent serum against mucoid variants of immunotypes 1, 3 and 5, according to Fisher's scheme, was shown to stimulate immune response in phagocytic test of all mucoid immunotypes.
The phagocytic and complement receptor function of polymorphonuclear neutrophils (PMN) from patients with sarcoidosis was studied using a kinetic assay which allows the distinction to be made between Fc receptor-mediated and C3b receptor-mediated particle uptake. The study included one group (A) of patients with active disease (n = 20), and one group (B) with silent or inactive disease who since 10 years had no symptoms or radiological signs of sarcoidosis (n = 11). Abnormal C3b receptor function was observed in both groups but the impairment was most pronounced in the A group. The presence of C3b receptor dysfunction in both groups with a quantitative difference between the groups, is compatible with C3b receptor dysfunction being a primary causal factor of sarcoidosis.
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