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PubMed1961

The "apparent molecular weight" of myelin forms prepared from normal red cells and some of its variations.

Some of the properties of myelin forms prepared by freezing, thawing, and homogenization of ghosts of human red cells are described, among these being the "apparent molecular weight" as found by light scattering, the effect of repeated freezing and thawing on the "apparent molecular weight," the quantity of fatty acids split off at various temperatures of freezing, the effect of the anticoagulant used, and the remarkable constancy in the "apparent molecular weight" met with when myelin forms are prepared from the ghosts of the red cells of normal people. Taken together, these observations lead to the description of a "standard technique" for the preparations of myelin forms; this technique can later be extended to the myelin forms obtained from animals other than man and also to those obtained from abnormal red cells.

Animals↗
PubMed1962

Phospholipidcholesterol membrane model. Control of resistance by ions or current flow.

A cephalin-cholesterol membrane model is described whose electrical resistance can be reversibly raised by CaCl(2) or lowered by KCl or NaCl whether these ions are added to the membrane by mechanical immersion or are driven in electrically. Either KCl or NaCl acts antagonistically to CaCl(2). Experiments with controlled pH indicate that the above effects depend somehow on combination of the cations with the phospholipid acidic groups. Also, they are correlated with decreased membrane hydration in CaCl(2) solutions, and increased hydration in KCl or NaCl solutions. It is conjectured that cells may regulate their transsurface ion pathways and fluxes by K-Ca competition for negatively charged binding sites on plasma membrane phospholipid. It is regarded as a corollary to say that a fundamental event in excitation is displacement of membrane Ca from such a site by catelectrotonically propelled K.

Cations↗