Treatment of psychogenic polydipsia with pindolol.
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The renal biopsies of 15 patients affected by polydipsia syndromes were examined under light and electron microscopes. The authors contend that the observed renal lesions (dilatation of the glomerular loops, tubular hypertrophy and vacuolization, and basal membrane swelling) are the morphologic result of tubular hyperfunction in the service of ion reabsorption. This, in turn, is secondary to the increased GFR.
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A case of neuroleptic malignant syndrome (NMS) was induced by the antidepressant trimipramine in a 47-year-old woman with obsessive compulsive disorder and major depression. NMS symptoms were associated with a brief episode of polydipsia, and both conditions may have had dopaminergic dysfunction as a common etiology. The patient improved with bromocriptine and dantrolene.
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