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Results for “THYROCALCITONIN”

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PubMedDate not supplied

[Changes in phosphorus-calcium metabolism in experimental renal insufficiency and after administration of dihydrotachysterol and thyrocalcitonin].

Development of experimental chronic renal insufficiency in rats was accompanied by an increase in concentration of residual nitrogen and phosphorus in blood and also by a decrease in intestinal absorption of Ca2+, however, no hypocalcemia was observed and the alkaline phosphatase activity was unaltered in blood serum. At the same time the renal insufficiency caused in some animals metastatic calcification of aorta and kidney, which was manifested by increased calcium concentration in these tissues. Administration of dihydrotachysterol increased the active transport of Ca2+ in rat intestine at the later steps of the impairment and led to development of moderate hypercalcemia and particularly to an increase in the degree of calcinosis of aorta and kidney. Administration of thyrocalcitonine did not prevent the hypercalcemia and calcinosis of internal tissues.

Alkaline Phosphatase↗

PubMed1975

[The mechanism of action of thyrocalcitonin on myocardial cells].

Thyrocalcitonin preserved its effect on the electric and contractile activity of the myocardial cells even under the influence of 2,4-dinitrophenol. Administration of the hormone during a considerable drop in amplitude and duration of the action potential due to DNP effect led to increase in the amplitude and to a still greater decrease in duration of the action potential. The contraction amplitude reduced by DNP was also augmented by the hormone administration.

Animals↗

PubMed1975

[Influence of thyrocalcitonin on the periodic motor activity of the gastro-intestinal tract].

Experiments were conducted on dogs with fistulae of the stomach and various portions of the small intestine in which there was recorded a periodic motor activity. It was shown that intravenous injection of a highly purified bovine thyrocalcitonin (TCT) in doses of 2--10 Units/kg (considerably exceeding the doses used at the clinic in the treatment of patients with bone pathology) caused no changes in a number of indices characterizing the motor periodic activity of the stomach and various portions of the small intestine, despite a distinct reduction (by 10--20%) of the calcium level in the blood serum.

Animals↗

PubMedDate not supplied

[Changes in the electrolyte composition of the blood of humans and animals under the influence of thyrocalcitonin].

A study was made of the effect of the thyroid hormone thyrocalcitonin (TCT) on the electrolyte composition of the plasma and erythrocytes. In healthy persons and in the patients with various diseases of the cardiovascular system administration of 1 Unit of TCT per 1 kg of weight led to a significant reduction of the total plasma calcium and its diffusible fraction and also of plasma sodium. A course treatment with the hormone led to the enhancement of the hypocalciemic effect. In dogs administration of 10 Units of TCT per 1 kg of weight produced a more pronounced hypocalciemic effect. The rest of blood electrolytes displayed no significant changes.

Adolescent↗

PubMedDate not supplied

Recent advances with thyrocalcitonin.

Thyrocalcitonin (TCT) is a 32 amino acid peptide hormone similar, but not identical, in structure from fish to man. Mammals produce the hormone in non-follicular thyroidal "C-cells" which can be identified visually using recently developed immunocytochemical methods. Although TCT exerts effects on the gut and kidney, bone seems to be the primary target tissue. The ability of TCT to restrict calcium fluxes from bone to blood and to inhibit bone resorption explains its utility for treating certain metabolic bone diseases, e.g. Paget's disease. The bone effects also account for the ability of TCT to combat a hypercalcemic challenge. Recent work suggests close relationships and a possible closed-loop feedback system between the gut and thyroid. In animals, gastrin is a potent TCT secretagogue; studies in man indicate that TCT, in turn, can effect gastric acid secretion and intestinal secretion of water and electrolytes. This gastrin-TCT relationship may help control levels of blood calcium during intestinal absorption of calcium following feeding. The ability of gastrin to stimulate TCT release has been applied clinically for the early diagnosis of medullary thyroid carcinoma (MTC), a C-cell tumor. Subclinical or questionable cases of MTC have been identified reliably using a simple, rapid provocative test involving pentagastrin injection and evaluation of blood samples by radioimmunoassay for elevated levels of TCT.

Amino Acid Sequence↗

PubMedDate not supplied

[Effect of thyrocalcitonin on the recovery processes in adrenaline lesion of the myocardium].

Administration of thyrocalcitonine (TCT) in doses of 0.1 and 1 Un/kg for 14 days prevented the development of myocarditis in rats receiving epinephrine (3 mg/kg) for 4 days reduced the death rate among the animals, increased their body weight and normalized the electrolytes composition in the heart. Given in a dose of 10 Un/kg the drug produced a less pronounced positive effect on the study values in the animals with experimentally-produced epinephrine lesion of the heart. According to the authors this may be occasioned by an intensified secretion of the parathyroid hormone in response to a multiple introduction of large TCT doses to the animals.

Animals↗

PubMedDate not supplied

[Effect of retabolil and thyrocalcitonin on mineral metabolism in the bones of rats following a fracture of the lower jaw].

In tests conducted with 65 male-rats of the Wistar line, aged 2-3 months subject to studies was the effect of retabolil (RB) and thyrocalcitonine (TCT) on the mineral metabolism in the osseous tissue following fracture of the lower jaw. The per cent of the Ca45 isotope incorporation in the injured and unaffected (contralateral) sections of the jaw and also in the thigh bones, lying far away from the site of the injury, was determined in dynamics. The agents RB and TCT, displaying different modes of action, produce a similarly oriented effect, viz. accelerated mineralization of the osseous tissue, which is evident from an increased incorporation of the Ca45 isotope in the fracture area during the first post-traumatic week, followed by declining incorporation on the 14-28th day.

Animals↗

PubMedDate not supplied

[Influence of thyrocalcitonin on the adenosine triphosphatase activity and the electrolyte balance of the rat myocardium].

The effect of thyrocalcitonine on the calcium, sodium and potassium levels in the blood plasma of the rats' myocardium and also on the activity of Na+-, K+- and Ca2+- ATP-ase of the sarcoplasmatic cardiac reticulum fragments were studied in experiments with rats. Calcitonine was found to force down the level of calcium in the blood plasma and to raise the sodium content in the myocardium on rats. The drug lessened the activity of the myocardial Na+-, K+-ATP-ase.

Adenosine Triphosphatases↗

PubMed1976

[Effect of parathyroid hormone and thyrocalcitonin on the cell membrane Na, K-ATP-ase of rat brain and kidney].

The influence of parathyroid hormone (PH) and thyrocalcitonine (TCT) on the enzymatic activity of ATP-ase systems of the membrane specimens of the cerebral cortex and renal cortex was investigated in experiments on rats. It was found that parathyroid hormone increased the activity of Na, K-ATP-ase and Ca-activated ATP-ase transport of the membranes in the brain and the kidneys both in vivo and in vitro. TCT caused analogous, but less expressed changes of the ATP-ase activity. Both hormones showed no influence on the Mg-ATP-ase activity of the both organs. It is supposed that the PH hormone influenced the membrane structures with the ATP-ase activity directly, while the action of TCT on them was mediated.

Adenosine Triphosphatases↗

PubMed2004

[Assay of thyrocalcitonin in cervical lymph node using fine-needle washings for the diagnosis of disseminated medullary thyroid carcinoma].

Fine-needle aspiration biopsy of cervical lymph nodes was carried out in 22 patients with suspected metastatic involvement with medullary thyroid carcinoma (MTS). It was followed by cytopathological examination of aspirates and assay of of thyrocalcitonin (TCT) in fine-needle washings. TCT determinations proved highly informative as well as significantly high in all seven cases of MTS involvement (26-8,484.87 pg/ml, mean 2,208 +/- 1,722 pg/ml).

Adolescent↗

PubMed1976

[Myocardial cell adenyl cyclase activity and the effect of thyrocalcitonin].

The thyrocalcitonin (TCT) effect under influence of some factors affecting the activity of membrane adenylcyclase (AC) of the ventricle myocardial cells in cold-blooded animals, was studied. The TCT positive inotropic effect is intensified by decrease in the potassium concentration in the medium, by blockade of alpha-adrenoreceptors with phentolamine, and inhibited by increase in the potassium concentration and blockade of beta-adrenoreceptors. The TCT action is preserved in presence of adrenaline.

Adenylyl Cyclases↗

PubMed1973

Inhibition by thyrocalcitonin of estrogen-induced bone resorption in the mouse pubic symphysis.

A specific local erosion of the medial edges of the pubic bones is induced by administration of estradiol cyclopentylpropionate (ECP) to thyroparathyroidectomized mice. This paper presents both histochemical and biochemical evidence that porcine thyrocalcitonin (TCT) inhibits this estrogen-mediated resorption of the pubic symphysis. A marked increase in osteoclasts with a resultant increase in demonstrable sites of acid phosphatase (AcP) activity was observed in serial sections of resorbing pubic symphyses from ECP-treated animals. Bioassay of excised pubic symphyses revealed a concomitant increase in AcP activity. When mice were treated with TCT in combination with ECP, a marked decrease in osteoclasts with a resultant decrease in demonstrable sites of AcP activity and inhibition of the resorption process occurred. The mouse pubic symphysis thus appears to offer a model for exploring cellular mechanisms by which TCT regulates bone metabolism.

Acid Phosphatase↗

PubMed1979

Effect of thyrocalcitonin on renal reabsorption of bicarbonate.

Porcine thyrocalcitonin (TCT) given intramuscularly at a dose of 2-3 MRC units/kg body weight induces a renal bicarbonate wasting probably at the level of the proximal tubule. This effect is found in normal children as well as in patients with renal tubular acidosis and with vitamin D deficiency. The mechanism by which TCT acts on the acidification mechanism is probably independent of parathyroid hormone (PTH) because the effect could also be obtained in hypoparathyroid patients.

Absorption↗

PubMed1984

[Value of the assay of plasma carcinoembryonic antigen and thyrocalcitonin in the detection of medullary cancer of the thyroid with amyloid stroma. Results of a familial survey of 47 subjects].

During a study of 80 subjects from the same family, 47 persons underwent clinical examination and blood sampling for carcinoembryonic antigen and thyrocalcitonin. A preliminary investigation had shown that two members of the family had histologically confirmed amyloid stroma MTC, 2 others had probable malignant disease, 3 children died of intestinal obstruction in the neonatal period, and a fourth child operated for megacolon when 3 days old was the descendant of 2 subjects with probable thyroid carcinoma. Three years later, the study was updated and concentrated on the patients with the highest risk of developing malignant disease. The diagnosis was confirmed in one patient considered to have probable MTC. One case of malignant disease was discovered in a child considered to be normal 6 years previously. Three other patients, considered to be normal 6 years before had very probable MTC. These results indicated that familial investigations including plasma calcitonin measurements after pentagastrin stimulation, are valuable when amyloid stroma MTC is diagnosed in one member of the family. This test should be repeated periodically. The surgical indications in patients with abnormal responses should take into consideration the psychological context.

Adolescent↗

PubMedDate not supplied

[Effect of thyrocalcitonin on mineral metabolism in experimental osteoporosis].

By the method of radioactive indication of ashed specimens of the femur, tibia, jaw bones and molars on a model of experimental osteoporosis in rats it is shown that the degree of mineralization of calcified tissues increases under the effect of thyrocalcitonin (TCT). The hypermineralization of jaw bones and, especially, of molars was attended by a lower 45Ca inclusion in these tissues. The structure of the adrenal cortex, kidneys, pancreas and thyroid returned back to normal under the effect of TCT and with carbohydrate rich nutrition, this occurring against the background of a high 45Ca concentration in these organs.

Animals↗

PubMed1976

[Treatment of Paget's disease with salmon thyrocalcitonin. Cooperative double-blind study].

Forty six patients suffering from Paget's disease in acute exacerbation were treated for three months with 80 u/day of synthetic salmon thyrocalcitonin. A control group of 36 patients received a placebo. A marked improvement in pain was seen in 60% of the treated patients and 15% of the placebo group (p less than 0.001). Functional impairment, when present, was also far more markedly decreased in the treated group (p less than 0.01). In comparison with the control group, the fall in hydroxyprolinuria and alkaline phosphatase levels was highly significant (p less than 0.001). This treatment is active against not only symptoms and signs, but also the biological criteria of activity of the disease. The side-effects of treatment consist above all of hot flashes (35% of cases) and nausea (24%). In only one case was it necessary to stop treatment because of intractable diarrhoea.

Adult↗

PubMedDate not supplied

[Serum thyrocalcitonin and parathyroid hormone content in children with diffuse toxic goiter and hypothyroidism].

Radioimmunoassay was used to study the blood thyrocalcitonin (TCT) and parathyroid hormone (PH) content in children with diffuse toxic goitre and hypothyrosis. The blood plasma TCT content was determined in 20 children with thyrotoxicosis and in 28 subjects with hypothyrosis. PH content was examined correspondingly in 18 and 20 patients. It was concluded that the blood TCT concentration is not significantly changed in children suffering from diffuse toxic goitre and hypothyrosis. PH content decreases in patients with thyrotoxicosis. Wide variability of PH individual values is peculiar to hyperthyrosis. TCT and PH have no essential significance in the pathogenesis of bone injuries and mineral metabolism changes in thyroid diseases of children.

Adolescent↗

PubMed1981

[Use of thyrocalcitonin by the trans-dentinopulpal route as a means of stabilizing and preventing rejection of human teeth homografts. Results and radiological changes (author's transl)].

Clinical and radiological results of an antirejection therapy based on the local action of a thyroid hormone, thyrocalcitonin, were studied. A double action was noted as it may stop the rhyzalase, and, more particularly, it reestablishes normal alveolodental relationships. Immunological factors are discussed. The therapeutic mode of action is emphasized as being a new method of local treatment.

Calcitonin↗