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[The bacteriology of normal wound healing following tooth extraction with special reference to anaerobic microorganism diagnosis].

In 10 patients with indication to tooth extraction swaps from the microbiotopes "sulcus/gingival pocket", "root canal", "socket" and "extraction wound 2 and 7 days after extraction" were investigated bacteriologically. The anaerobic-aerobic mixed flora with predominance of anaerobes verified in the microbiotopes "sulcus/gingival pocket", "socket" and "extraction wound 2 days after extraction" was identically. The flora of the root canal was distinguished by a smaller amount of microbes with predominance of aerobes. In the 7 days old extraction wound only single aerobes could be verified whereas anaerobes were missed totally.

Alveolar Process

Research into changes in canine maxillary trabecular bone orientation after tooth extraction.

This paper described the morphological changes in the trabecular bone orientation of the jaw bone due to reduction in the applied functional pressure. All teeth on the right side of the upper and lower jaws were extracted from canine specimens. Experimental periods were set at 0.5, 1, 1.5, 2, 2.5, 3, 5, 7, 9, 11, and 13 months after tooth extraction. The trabecular bone orientation was measured by an image analyzer as morphometrical parameters. The loss of teeth changed the support system for functional pressure, resulting in the marked disordering of the trabecular bone orientation.

Alveolar Process

A study of the reasons for tooth extraction in a Canadian population sample.

The reasons for extraction of teeth were determined in a Canadian population sample of 909 patients, ranging in age from 14 to 91 years. Caries was the primary cause of extraction (63%), followed by periodontitis (34%). For the adult age groups, the percentages were approximately the same. While periodontitis was the cause of one-third of the extractions, these occurred in only one-fifth of the population. Although there is a commonly expressed belief that periodontitis is the major cause of tooth loss in adults, a review of both historical and contemporary literature does not support this position. According to the current concept of the natural history of periodontal disease, only about one-fifth of the population, or less, is likely to have periodontitis severe enough to cause tooth loss. This view is consistent with data from this and most other studies on the reasons for tooth extraction.

Adolescent

Purification of rabbit bone morphogenetic protein derived from bone, dentin, and wound tissue after tooth extraction.

Bone morphogenetic protein (BMP) was extracted from bone matrix, dentin matrix, and wound tissue after tooth extraction in rabbits, and purified. These purified fractions were shown to be homogeneous by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis (SDS-PAGE), and induced new bone in situ in 3 weeks when implanted into the calf muscles of Wistar rats. The dentin matrix-derived BMP was different from the other two types in molecular weight and the properties revealed in the process of purification. However, each tissue-derived BMP was shown to induce new bone growth in a bioassay of xenogenic implantation. For this reason, BMP is thought to have subunits with certain commonalities in different tissue.

Animals

[Pneumopericardium with combined emphysema of the skin and mediastinum following tooth extraction].

Emphysemas of the skin in the region of the cheek and face after surgical tooth extraction are relatively rare complications that can eventually lead to formation of an emphysema of the mediastinum and very rarely also to a pneumopericardium. The reason for this is often an instrumentally conditioned pressure increase in the oropharynx if this pressure increase leads to the entry of air into the wound region. There are also other mechanisms resulting in the formation of spontaneous mediastinal emphysema that can lead to a secondary emphysema. Possible reasons for the occurrence of a combined emphysema of the skin, the mediastinum and the pericardium are discussed.

Adult

Levator nasolabialis muscle transposition to prevent an orosinus fistula after tooth extraction in horses.

The ventral part of the levator nasolabialis muscle was transposed to the alveolar defect after sinusotomy and tooth extraction in five normal horses and six horses with a tooth root abscess and sinusitis. In the normal horses at weeks 6, 10, 14 and 18, the transposed muscles remained viable and were incorporated into the recipient sites, and orosinus fistulae did not form. Histologically, there was a progressive transition from muscle to fibrous tissue. There was no facial deformity or loss of nasal function at the donor site. A localized abscess was associated with incomplete removal of tooth root fragments in one horse. After 1 year or more, five horses treated for dental disease had complete resolution of clinical signs. One horse continued to have intermittent mild nasal discharge.

Animals

Reasons given for tooth extraction in Hong Kong.

Two hundred and seventy dentists, systematically selected from the membership lists of the Hong Kong Dental Association, were sent forms on which they were invited to record the reasons for tooth extraction in all patients aged 16 years and above over a period of five to six weeks. Third molars were excluded. Fifty-five per cent of the recording sheets dispatched were returned with usable data. Data were provided on 8516 extractions performed for 6331 patients. Overall caries was the reason given for 60 per cent of extractions; periodontal disease for 28 per cent; prosthetic indications for six per cent; trauma (which included tooth wear) for four per cent; and orthodontic and other reasons for two per cent. Extractions for periodontal reasons were more common in those aged 40 years and above, but periodontal disease did not exceed caries as a reason for extraction even in those aged 60 years and over. The tooth type most frequently extracted was the first molar. Mandibular incisors were the teeth most commonly extracted for periodontal reasons. In this community, which has benefited from water fluoridation since 1961, caries was the dominant reason given by dentists for tooth extractions in all age groups of the subjects studied.

Adolescent

Analgesic effect of fentiazac after tooth extraction or minor oral surgery.

A new nonsteroidal anti-inflammatory agent, fentiazac, was used for analgesia after tooth extractions and minor oral surgery in two Japanese dental hospitals. The drug was administered as a single oral dose of either 50 mg or 100 mg. The 50-mg dose provided rapid analgesic effect, but its effect lasted only two to three hours in a number of patients. At a dose of 100 mg, fentiazac proved effective for 85% of 53 patients, usually providing marked reduction of disappearance of pain within one hour or less. Among patients in whom pain reappeared, the mean time for recurrence was four hours, indicating a satisfactory duration of analgesic effect. One side effect--loss of appetite--was reported by one patient in the entire series of 71 subjects. It is concluded that fentiazac is a highly effective analgesic agent with a wide margin of safety for use after dental procedures that produce pain.

Acetates

A biochemical study of aminopeptidases in the palatal mucosa of the rat following tooth extractions.

Aminopeptidase activities were studied biochemically from the supernatants of the homogenates prepared from the normal and post extraction palatal mucosa of the rat. The determinations were carried out at 0.5, 1, 2, 4, 8 and 16 hours and 1, 2, 3, 5 and 7 days following extraction using N-L-aminoacyl-2-naphthylamines of arginine, glycine, leucine, proline and valine as the substrates. In addition, in the second part of the study the hydrolysis of N-L-aminoacyl-2-naphthylamines of alanine, histidine, isoleucine, lysine, phenylalanine, serine, threonine, tyrosine and valine was tested at 1, 3 and 5 days following extraction. The effect of chloride ions (0.2 M NaCl) on the hydrolysis of arginine and lysine derivatives was also tested. The specific activities of aminopeptidases obtained from the extraction-wound side were compared to those of the control side at each time interval. Tooth extraction caused a considerable reduction in the specific activities of aminopeptidases in the surrounding palatal mucosa immediately after extraction (at 0.5 hr.). The specific activities in the wound tissue remained generally below the control levels for 24 hours and reached their maximum within 5 days following extractions. The highest relative increase was obtained with N-L-valyl-2-naphthylamine. Arginine aminopeptidase was activated by chloride ions on an average 20 per cent more in the wound tissue than the control. This effect can be considered suggestive of the activation of aminopeptidase B in the post extraction palatal mucosa.

Aminopeptidases

Painful, nonhealing, tooth extraction socket.

The oral signs and symptoms of acute leukemia include gingival hypertrophy, gingival hemorrhage, petechiae and ecchymoses, mucosal ulceration, paresthesia, tooth pain, and oral infections. This case was unusual in that the diagnosis of acute leukemia was made only after a biopsy specimen of tissue protruding from the socket of a recently extracted tooth disclosed malignant cells suggestive of leukemia or lymphoma. The diagnosis of epulis granulomatosa should be made only after clinical, radiographic, and microscopic studies have been performed to rule out a malignant process.

Diagnosis, Differential

Reasons for tooth extraction among Tanzanians.

In 1988 a study was carried out among Tanzanians of different age groups to determine the reasons for tooth extraction. The major reason was found to be dental caries or its associated complications (81%) while periodontal diseases was the runner-up (13%). The molars teeth were the most commonly extracted. The results of this study are important in planning resources for and provision of emergency oral health care especially for the rural population.

Adolescent

Protein synthesis in wound after tooth extraction in pancreatectomized diabetic rats.

The incorporation of alanine C14 in protein synthesis was analyzed in recently formed alveolar tissue after tooth extraction in partially-pancreatectomized diabetic rats. The incorporation of alanine C14 was higher in diabetic animals than in treated diabetic and control groups. The results can be explained by a delay in bone tissue repair.

Alanine

[Vivisection studies on the effects of unilateral tooth extraction on growth of the skull and masticatory musculature. I. Overall skull, orbita, zygomatic arch, rear skull (author's transl)].

Skull growth is affected by numerous factors, including dentition. Animal experiments have assumed considerable importance in connection with such studies. This series of publications deals with the response of the skull skeleton and masticatory muscles to extraction of each emerging tooth in the right half of the jaws of Vietnamese belly pigs. The animals were slaughtered at various ages ranging from 6 to 12 months, throughout an important phase of post-natal skull development. Biomathematical methods were used to analyse the macerated skull and the masticatory musculature. Linear differential equations have proved useful for describing growth processes. The 1st report deals with the distances measured for the overall and rear skull, the orbita and the zygomatic arch. Differences between the right and left sides are slight with respect to these distances. Significant differences were found only in the range of the front part of the zygomatic arch during the 6th, 7th, 8th, 11th and 12th month of life.

Animals

Articulatory behavior pre and post full-mouth tooth extraction and alveoloplasty: a cinefluorographic study.

High speed cinefluorography was used to track articulatory movements preceding and following full-mouth tooth extraction and alveolplasty in two subjects. Films also were made of a control subject on two separate days. The purpose of the study was to determine the effects of dramatically altering the structural dimensions of the oral cavity on the kinematic parameters of speech. The results showed that the experimental subjects performed differently pre and postoperatively though the changes were in different directions for the two subjects. Differences in both means and variabilities of kinematic parameters were larger between days for the experimental (operated) subjects than for the control subject. The results for the control subject also showed significant differences in the mean values of kinematic variables between days though these day-to-day differences could not account for the effects found pre- and postoperatively. The results of the kinematic analysis, particularly the finding that transition time was most stable over the experimental conditions for the operated subjects, are used to speculate about the coordination of normal speech.

Alveoloplasty

[Tooth extraction in patients suffering from hemophilia A under the cover of cryoprecipitates and epsilon-aminocaproic acid].

Tooth extractions were carried out in 75 patients with haemophilia A after infusion of a single dose of cryoprecipitate and 4 g of epsilon-aminocaproic acid. During the 7-10 day period of follow-up, the patients received epsilon-aminocaproic acid by mouth. In 32 of 44 patients with severe or moderate haemophilia and in 22 of 31 patients with mild haemophilia, healing was uneventful and no bleeding complications occurred. Only in 5 patients with severe haemophilia and in 1 patient with mild heamophilia bleeding from tooth sockets was extensive enough to require further replacement therapy. The results show that epsilon-aminocaproic acid in conjunction with a single infusion of cryoprecipitate can insure hemostasis after dental extraction in patients with haemophilia A.

Adolescent