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Testing of concentric visual field constriction by means of scotopic visually evoked potentials.

Using scotopic visually evoked potentials (VEP), an objective test of concentric absolute field defects is presented. At 0.8 log units above the mean VEP threshold, the full field, the central area of 50 degrees diameter, and the complementary peripheral field were flash stimulated. In 13 normal subjects the peripheral VEP response was larger in amplitude and shorter in latency compared to the central response. In four cases of concentric field restriction due to hysteria and malingering, the same results were found. In three cases of retinitis pigmentosa and advanced glaucoma, the peripheral VEP sensitivity was worse than the central one or no response could be found. The amount of stray light was estimated as the difference of the thresholds for central and peripheral stimulation (1.6 to 1.8 log units) in a patient with a residual central field of 20 degrees.

Adolescent

[The correlation between changes of static central visual fields and posterior polar lesions in high myopia].

The static central visual fields tested by an Octopus Field Analyzer and posterior polar lesions in 53 cases with high myopia were investigated. Cases with low and moderate degrees of myopia were the controls. The results demonstrate that the visual field defects are present in the high myopic eyes and they are related to the degree of high myopia, the age of the patient and the severity of the posterior polar lesion. The visual field defects present multiform and multilevel in character and they do not completely correspond to the fundus lesions. The appearance of central relative scotomata in high myopic eyes detected by a quantified automated perimeter is prior to the appearance of macular lesions seen under an ophthalmoscope. Therefore, the quantified automated central visual field examination is helpful to the early diagnosis of macular disease in high myopia.

Adolescent

Visual field loss following blunt ocular trauma.

14 patients (14 eyes) who sustained hyphema after blunt ocular trauma underwent visual field testing on a Humphrey field analyzer. The severity of field defects based on mean deviation (MD) and corrected-pattern standard deviation (CPSD) p values was correlated with age, presence of hyphema and the extent of angle recession. Over 60% of eyes with blunt ocular trauma suffer from a significant visual field loss (MD < 5%). There was no correlation between severity of field defects and the extent of hyphema or the angle recession. MD p values were found to be associated with older group, but not CPSD p values.

Adolescent

Visual field and retinal nerve fibre layer in early glaucoma after optic disc haemorrhage.

Computerized visual field testing with the Competer automatic perimeter including automatic profile perimetry revealed early glaucomatous field loss in 9 of 10 eyes with photographically demonstrable retinal nerve fibre layer (RNFL) defects after optic disc haemorrhages despite the fact than conventional routine perimetry had failed to do so. In 7 of these cases the Competer central pattern test was abnormal; in 2 cases field defects could be shown only when automatic high-resolution static profile perimetry was performed and directed according to the information present in wide-angle RNFL photographs. A field defect was also found in one of five eyes with no photographic RNFL changes. Visual field defects seem to occur in a higher proportion of cases with RNFL defects than was previously thought, but they can be very subtle and hard to find. There are, however, cases where in spite of the presence of an indisputable RNFL defect no visual field defects can be shown even with painstaking technique and conversely field defects may be present without RNFL defects. Automatic perimetry and RNFL photography complement each other in early detection and quantitation of glaucomatous damage.

Aged

The learning and fatigue effect in automated perimetry.

A visual field test was performed on 100 volunteers to study learning or fatigue effects during one session. The test was carried out with the help of the Octopus program J1, which measures the threshold 12 times at 3 test locations. In the majority of cases the sensitivity was quite stable during the session. We noted no difference between trained and untrained subjects or between normal and pathological eyes. However, patients with refractive errors, especially myopes, revealed a larger learning effect than did emmetropes.

Adolescent

Static threshold asymmetry in early glaucomatous visual field loss.

Ten normal subjects underwent static threshold visual field testing of both eyes with the Humphrey perimeter, with one eye tested twice. The mean sensitivity of the field seemed virtually identical in the two eyes, with the average difference between the right and left eyes (0.65 decibels [dB]) being no greater than the testing error as reflected in the difference between the same eye tested twice (0.7 dB). The authors provide the mathematical basis for recognizing that a right eye-left eye difference in mean sensitivity might be abnormal. Additional information is needed about the variance of the right eye-left eye difference in the population at large, but present information suggests that a 2-dB difference may be meaningful on a single examination. A 1.5-dB difference is statistically significant if confirmed on a second test, and a difference as small as 1 dB may be meaningful if shown consistently in a series of four examinations. In all cases, nonglaucomatous causes of field abnormality needs to be ruled out, and the generalized asymmetry is most meaningful if it is consistent with asymmetry of cupping or intraocular pressure. Several cases are reported in which a mild (1 dB) generalized depression of the visual field is the only recognizable abnormality in the visual field in eyes with early glaucoma.

Adult

Representation of the visual field in the striate cortex: comparison of MR findings with visual field deficits in organic mercury poisoning (Minamata disease).

PURPOSE: To compare MR imaging findings of the striate cortex with visual field deficits in patients with Minamata disease and to reestimate the classical Holmes retinotopic map by using the data obtained from comparing visual field abnormalities with degree of visual cortex atrophy. METHODS: MR imaging was performed in eight patients with Minamata disease who had been given a full neuroophthalmic examination, including Goldmann dynamic perimetry. The atrophic portions of the calcarine area were measured in the sagittal plane next to the midsagittal image and represented as a percentage of atrophy of the total length of the calcarine fissure. MR findings were compared with results of a visual field test. RESULTS: The visual field test revealed moderate to severe concentric constriction of the visual fields, with central vision ranging from 7 degrees to 42 degrees (mean, 19 degrees). The ventral portion of the calcarine sulcus was significantly dilated on MR images in all patients. A logarithmic correlation was found between the visual field defect and the extent of dilatation of the calcarine fissure. The central 10 degrees and 30 degrees of vision seemed to fill about 20% and 50% of the total surface area of the calcarine cortex, respectively. CONCLUSION: Visual field deficits in patients with Minamata disease correlated well with MR findings of the striate cortex. Our data were consistent with the classical Holmes retinotopic map.

Atrophy

Visual field area response to increased target intensity: a method of detecting ocular disease.

Application of computer digitizing methods to conventional kinetic visual field test data permits mathematical analysis of these data. In some cases this provides more information than is available by a simple inspection of the field charts. This is demonstrated by analysis of multiple isopter data for a patient with open-angle glaucoma and a patient with retinitis pigmentosa.

Adult

Intra- and interrater agreement with cumulative defect curves.

PURPOSE: To examine intra- and interrater agreement when analyzing cumulative defect curves. Cumulative defect (Bebié) curves provide a graphical representation of the visual field and allow a subjective classification of diffuse and localized loss. METHODS: We used 75 Humphrey 30-2 visual field tests, randomly chosen from a database of 782 fields of 113 patients with open-angle glaucoma. Cumulative defect curves were generated and randomly arranged into five sets, with each set containing the 75 curves in a unique sequence. Five raters (two experienced and three inexperienced) rated each set and classified each curve as showing diffuse loss, localized loss, both diffuse and localized loss, or no loss. The intra- and interrater agreement in rating the curves was then analyzed. RESULTS: Intrarater agreement ranged from 73.3-88.0% for perfect rater agreement, with 5 identical ratings. Agreement for experienced versus inexperienced raters gave similar results (means: 84.0% and 77.8%, respectively, for perfect agreement). Interrater agreement for each set, evaluated by the kappa statistic, was substantial for all 5 sets (0.65-0.71). Kappa values for each set were comparable for experienced and inexperienced raters (0.72-0.83 and 0.59-0.69 respectively). CONCLUSIONS: Analyzing the nature of visual field loss using the cumulative defect curve is simple to learn and provides high intrarater agreement as well as substantial interrater agreement.

Glaucoma, Open-Angle

Computerized visual field screening in the management of patients with ocular hypertension.

Visual field testing which the Computer fully automatic computerized perimeter (Heijl & Krakau 1975) employing a supra-liminal screening test procedure was used in a material of 1013 eyes with ocular hypertension in which earlier routine perimetry (kinetic and static) on the Goldmann perimeter had yielded a normal result. The automatic screening was repeated if positive, and manual control perimetry was used in order to confirm or reject identified field defects. This procedure revealed field defects that could be confirmed at both automatic and manual perimetry in 3.6% of the eyes. In the control group the incidence of field defects found at manual perimetry during the same time interval was calculated at 0.4%. Thus automatic screening revealed several times more field defects than manual routine perimetry. Eyes in which repeated automatic screening had indicated defects which manual control perimetry failed to confirm, showed a high percentage of field loss at later follow-up. The results are discussed, and the conclusion is drawn that automatic screening is clearly superior to manual routine perimetry used at present. The most practical solution in many eye departments would be to use a computerized perimeter for the visual field screening of glaucoma suspects.

Adult

A confrontation test of visual fields in the low-vision patient.

We report a simple method for measuring the extent of the visual field in patients from whom this measurement is difficult. One Maddox rod is used before the eye under test. Through the Maddox rod lens, this eye sees a white streak produced by a penlight. While fixating this white streak another penlight is brought into the field of view from the periphery. The patient is required to report only whether he sees one or two light streaks. The results correlate well with field measurements made on the tangent screen in patients with simulated field losses.

Humans

Automated suprathreshold screening for glaucoma: the Baltimore Eye Survey.

PURPOSE: To evaluate automated suprathreshold perimetric screening for glaucoma in a population-based survey of ocular disorders in east Baltimore, Maryland. METHODS: A population-based sample of persons > or = 40 years of age residing in 16 clusters was selected for an ocular screening examination that included automated suprathreshold testing with the Full Field 120 program of the Humphrey Field Analyzer. Subjects who failed the test underwent manual testing to confirm the defect. Subjects were referred for definitive examination by an ophthalmologist if they had an abnormal field, visual acuity worse than 20/30, intraocular pressure > 21 mm Hg, optic disc damage, a history of glaucoma, or shallow angles. The sensitivity and specificity of the automated visual field testing for identifying glaucoma was estimated and compared with other methods to screen for glaucoma. RESULTS: Of 5,341 subjects > or = 40 years of age who underwent a screening eye examination at neighborhood centers, 4,735 (89%) completed the automated field test. The median test time was 7.25 minutes per eye. Screening test results were abnormal in one or both eyes in 1,234 (26%) of the subjects. Kinetic perimetry was performed on 95% of these subjects, and defects were confirmed for 448 (36%) of them. Hence, 9.5% of the 4,735 subjects who completed the automated test were referred for definitive examination because the defect on automated perimetry was confirmed on manual testing. For a specificity of 90%, the sensitivity of the screening visual field test to detect glaucoma was 52% for 17 or more relative or absolute defects, higher than that of intraocular pressure at 39% for a cut-off of 20.5 mm Hg, vertical cup-to-disc ratio at 45% for a cut-off of 0.53, narrowest remaining rim width at 42% for a cut-off of 0.16, and was comparable to a combination of these and other nonfield parameters. CONCLUSION: Suprathreshold testing performed better than nonperimetry-based screening tests for glaucoma. However, a number of logistical weaknesses of this visual field screening method were identified.

Adult

Glaucoma Hemifield Test. Automated visual field evaluation.

We have developed an algorithm, the Glaucoma Hemifield Test (GHT), for automated evaluation of single static threshold visual field test results in glaucoma. The GHT uses empirically determined limits of normality for up-down differences in the Statpac probability maps of the Humphrey Field Analyzer to detect localized visual field loss. It is also constructed to detect field loss that is symmetric around the horizontal meridian. Analysis is done in five corresponding pairs of sectors that are based on the normal anatomy of the retinal nerve fiber layer. Deviations from the age-corrected normal threshold in the most sensitive portions of the visual field are used to detect general reductions of sensitivity or abnormally high sensitivities. The GHT provides brief visual field evaluations printed on the field chart as plain text. The aim of this article is to describe the fundamentals of the analysis program and to provide clinical examples.

Adult

Retinal toxicity in long term hydroxychloroquine treatment.

OBJECTIVE: To report clinical experience from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) who were receiving recommended doses of hydroxychloroquine for more than six years, and were monitored for evidence of hydroxychloroquine related retinopathy every six months. METHODS: A prospective (and continuing) evaluation was made of the potential retinal toxicity of hydroxychloroquine in a cohort of 360 Greek patients followed for RA and SLE, 58 of whom have received long term treatment ( > six years). Fundoscopy, colour vision tests, dark adaptation tests, visual field testing, automated perimetry, and electroretinogram were performed every six months. RESULTS: Among 58 patients receiving hydroxychloroquine for more than six years, two relatively young women (3.5%), one treated for RA and the other treated for SLE, developed characteristic hydroxychloroquine related toxic retinal lesions after cumulative doses of 700 g (6.5 years) and 730 g (8 years) of hydroxychloroquine, respectively. Bilateral visual acuity was 6/6 and 6/7.5, respectively; both patients had normal colour perception. Despite an early diagnosis and cessation of treatment, permanent visual field paracentral scotomata in both patients, and persisting lesions in fluorescein angiography in the patient with SLE, were observed at 4.5 and 3 years of follow up, respectively. No other specific cases of hydroxychloroquine related retinopathy have to date been identified in the remaining 302 patients. CONCLUSION: Cases of irreversible, hydroxychloroquine related retinopathy in patients who did not receive overdoses have not been reported previously. The present observations in two relatively young patients should raise our concern regarding the long term usage of an increasingly popular medication in rheumatology practice.

Adult

Improving the sensitivity of the OKP visual field screening test with the use of neutral density filters.

Oculokinetic perimetry (OKP) has been developed to screen for glaucomatous field loss but has relatively poor sensitivity when compared with threshold perimetry. Forty-two eyes from 42 patients with glaucomatous field loss on Humphrey threshold perimetry and 32 normals performed hand-held OKP under controlled conditions of refraction and lighting. Those who passed the standard test had their OKP cutoff determined with increasing neutral density filters (NDFs) at a new point 15 degrees from fixation in the inferotemporal field (where first glaucomatous defects are rarest). OKP was then repeated with a NDF that increased the ambient light by 0.3 log units from cut off. Of the 16 glaucomatous eyes to pass standard OKP, 9 failed the NDF test, improving the sensitivity from 62% to 83% (p < 0.05). These 9 eyes had field defects that were significantly less severe (mean defect 4.85 vs 7.91 (p < 0.05) and corrected pattern standard deviation 4.12 vs 7.00 (p < 0.05) and were from younger patients (mean age 56 vs 66 years; p < 0.05) than those who failed standard OKP. None of the 32 normals failed standard OKP and only 1 of 32 failed the NDF test. The use of NDFs to customise OKP, producing essentially a staged suprathreshold contrast sensitivity test, appears to increase the sensitivity of the OKP screener without degrading its specificity, particularly in younger subjects.

Aged

Red square test for visual field screening. A sensitive and simple bedside test.

A reliable bedside test for screening of visual field defects is a valuable tool in the examination of patients with a putative disease affecting the sensory visual pathways. Conventional methods such as Donders' confrontation method, counting fingers in the visual field periphery, of two-hand confrontation are not sufficiently sensitive to detect minor but nevertheless serious visual field defects. More sensitive methods requiring only simple tools are also described. In this study, a test card with four red squares surrounding a fixation target, a black dot, with a total test area of about 11 x 12.5 degrees at a distance of 30 cm, was designed for testing experience of red colour saturation in four quadrants, red square test. The Goldmann visual field was used as reference. 125 consecutive patients with pituitary adenoma (159 eyes), craniopharyngeoma (9 eyes), meningeoma (21 eyes), vascular hemisphere lesion (40 eyes), hemisphere tumour (10 eyes) and hemisphere abscess (2 eyes) were examined. The Goldmann visual field and red square test were pathological in pituitary adenomas in 35%, in craniopharyngeomas in 44%, in meningeomas in 52% and in hemisphere tumours or abscess in 100% of the eyes. Among these, no false-normal or false-pathological tests were found. However, in vascular hemisphere disease the corresponding figures were Goldmann visual field 90% and red square test 85%. The 5% difference (4 eyes) was due to Goldmann visual field defects strictly peripheral to the central 15 degrees. These defects were easily diagnosed with two-hand confrontation and

Adult

Computerised perimetry.

During the last few years computerised perimetry has become a clinical reality. This new technique eliminates the operator's error, ensures reproducibility of test procedures and parameters and makes visual field testing of large numbers of patients possible. Great differences exist between computerised perimeters. Differences in hardware for example, the way in which stimuli or field charts are produced may be striking but even more important are differences in software, especially test algorithms. The results obtained with some instruments and test programmes are of such high quality that the same level of performance may be almost impossible to obtain with manual perimetry, at least in a clinical setting. Nevertheless, improvements can be expected in the future particularly in adaptive tests and in computerised interpretation of the fields.

Computers