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Results for “interoperability”

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58 records · Page 4Linked to original sources

PubMed1990

A study of variance in densitometry of retinal nerve fiber layer photographs in normals and glaucoma suspects.

The main object of this research was to develop a reliable method of screening glaucoma suspects and patients for early loss of or changes in the retinal nerve fiber layer (RNFL). This study quantifies the variances due to photography, digitizing, and analysis of red-free photographs of the RNFL. The influence of pupil size, optic disc position and eye movements, film processing, digitizing, and intra- and interphotographic-session and intra- and interoperator variances were established. It was found that pupils needed to be dilated to at least 6 mm, that the optic disc had to be positioned in a standardized area in the negative, that the head of the subject had to remain still during photography, and that film processing and digitizing of the negative needed to be strictly controlled to minimize the variance in collection of densitometry data from RNFL red-free photographs. It was established that focusing of the negatives during digitization was not crucial. Criteria were defined for acceptable negatives. Interphotographic-session and intraoperator variances were not significant in most cases when negatives were digitized to these criteria. Analysis of interphotographic-session variance showed that there were still some factors in photography, film processing, and/or image digitizing that were not sufficiently controlled for long-term follow-up without normalization of the data. Densitometry data gathered using the established protocol, from negatives of 71 subjects were analyzed; best sensitivity and specificity rates of 80% and 100%, respectively, were achieved for the diagnosis of glaucoma.

Adult↗

PubMed1977

Investigation of variable factors in drilling bone.

Experiments were conducted to investigate the pressures that are exerted on drills during the preparation of bone. Twenty operators used six different types of drills at high and low speeds to prepare standardized holes and slots in animal bone. The peak vertical forces exerted varied between 5.98 and 24.32 newtons (x = 12.45 newtons). The mean vertical forces varied between 4.22 and 18.93 newtons (x = 9.16 newtons). Spear point and twist drills were associated with significantly lower operating pressures and shorter operating times than round and fissure burs. These differences, however, were much less than the interoperator variations.

Animals↗

PubMed1988

Human left main coronary artery blood flow: noninvasive Doppler echocardiography with sample volume tracking.

We developed sample volume tracking units that controlled the pulsed ultrasonic Doppler sample volume location in relation with the anterior-posterior movement of the human left main coronary artery (LMCA). Combined with noninvasive Doppler echocardiographic mechanical sector scanners (DS), the trackers controlled the axial location of the sample volume by range gate control. The Doppler angle was minimized with the long axis of the imaged LMCA. Both stored waveform, memory-driven (MD) and real-time (RT) trackers were developed. These devices were used to measure blood velocity spectral waveforms and lumen diameters, which were used to calculate flow. Using the RT tracker, we compared DS measurements with known flows (0-1000 ml/min) in a moving 4 mm tygon tubing phantom (r = 0.92, SEE = 32 ml/min). Using the MD tracker, we compared the DS with simultaneous invasive flow measurements in 11 patients with angiographically normal coronaries and ventricular function during cardiac catheterization. Using the RT tracker, we compared the DS measurements with subsequent nonsimultaneous, invasive flow data in 8 similar patients. Invasively determined flows were calculated from angiographic diameters and blood velocities which were obtained with a Doppler velocimeter catheter. Regression coefficients (r) were: (Table: see text). V = maximum velocity, D = diameter, Q = mean flow, *p less than .05 Interoperator and intraoperator variabilities in vivo of DS measurements with RT tracking were 21% and 15%, respectively. We conclude that Doppler echocardiography with either MD or RT sample volume tracking may be of limited clinical usefulness in the noninvasive measurement of phasic left main coronary artery blood flow in unselected patients.

Angiocardiography↗

PubMed2025

A decentralized future for the open-science databases.

The continuous and reliable open access to curated biological data repositories is indispensable for accelerating rigorous scientific inquiry and fostering reproducible research outcomes. However, the current paradigm, which relies heavily on centralized infrastructure for the storage and distribution of foundational biomedical datasets, inherently introduces significant vulnerabilities. This centralized model is susceptible to single points of failure, including cyberattacks, technical malfunctions, natural disasters, and even political or funding uncertainties. Such disruptions can lead to widespread data unavailability, data loss, integrity compromises, and substantial delays in critical research, ultimately impeding scientific progress. The downstream effect of such interruptions can be the widespread paralysis of diverse research activities, including computational, clinical, molecular, and climate studies. This scenario vividly illustrates the inherent dangers of consolidating essential scientific resources within a single geopolitical or institutional locus. As data generation is accelerating and the global landscape continues to fluctuate, the sustainability of centralized models must be critically re-evaluated. A shift toward federated and decentralized architectures may offer a robust and forward-looking approach to enhancing the resilience of scientific data infrastructures by reducing exposure to governance instability, infrastructural fragility, and funding volatility, while also promoting equity and global accessibility. Inspired by established models such as ELIXIR's federated infrastructure and the policy and funding frameworks developed by CODATA and the Global Biodata Coalition (GBC), emerging Decentralized Science (DeSci) initiatives can contribute to building more resilient, fair, and incentive-aligned data ecosystems. The future of open science depends on integrating these complementary approaches to establish a globally distributed, economically sustainable, and institutionally robust infrastructure that safeguards scientific data as a public good, further ensuring continued accessibility, interoperability, and preservation for generations to come. Here, we examine the structural limitations of centralized repositories, evaluate federated and decentralized models, and propose a hybrid framework for resilient, fair, and sustainable scientific data stewardship.

data accessibility↗